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Chemistry

D-Index
47
Citations
8144
World Ranking
15629
National Ranking
3935

Overview

Punit P. Seth is affiliated with Ionis Pharmaceuticals in the United States. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, where they have contributed extensively, particularly in Molecular Biology. Their work also intersects with subfields such as Pulmonary and Respiratory Medicine, Radiology, Nuclear Medicine and Imaging, Biophysics, and Rheumatology.

The scientist's main research topics include:

  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • DNA and Nucleic Acid Chemistry
  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • CRISPR and Genetic Engineering
  • RNA regulation and disease

Punit P. Seth has published frequently in several scientific journals. The most common publication venues are:

  • Nucleic Acids Research (9 publications)
  • Journal of the American Chemical Society (6 publications)
  • Nucleic Acid Therapeutics (4 publications)
  • Nature Biotechnology (1 publication)
  • Trends in Pharmacological Sciences (1 publication)

Their recent notable papers include:

  • "Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS," 2021, Nature Biotechnology
  • "The Interaction of Phosphorothioate-Containing RNA Targeted Drugs with Proteins Is a Critical Determinant of the Therapeutic Effects of These Agents," 2020, Journal of the American Chemical Society
  • "Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides," 2021, Nucleic Acids Research
  • "Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides," 2020, Nucleic Acids Research
  • "Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins," 2020, Journal of the American Chemical Society

Frequent co-authors of Punit P. Seth comprise:

  • Michael T. Migawa
  • Eric E. Swayze
  • Stanley T. Crooke
  • Xue-hai Liang
  • Graeme C. Freestone

Best Publications

  • 6-modified bicyclic nucleic acid analogs

    Eric E. Swayze;Punit P. Seth

  • The Medicinal Chemistry of Therapeutic Oligonucleotides

    W. Brad Wan;Punit P. Seth

  • 5′-modified bicyclic nucleic acid analogs

    Punit P. Seth;Eric E. Swayze

  • Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.

    Wen Shen;Cheryl L. De Hoyos;Michael T. Migawa;Timothy A. Vickers

  • Single-stranded siRNAs activate RNAi in animals

    Walt F. Lima;Thazha P. Prakash;Heather M. Murray;Garth A. Kinberger

  • Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals.

    Punit P. Seth;Andrew Siwkowski;Charles R. Allerson;Guillermo Vasquez

  • Carbocyclic alpha-l-bicyclic nucleic acid analogs

    Punit P. Seth;Eric E. Swayze

  • Substituted alpha-l-bicyclic nucleosides

    Punit P. Seth;Eric E. Swayze

  • Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

    Punit P. Seth;Guillermo Vasquez;Charles A. Allerson;Andres Berdeja

  • Bicyclic cyclohexose nucleic acid analogs

    Michael T. Migawa;Punit P. Seth;Eric E. Swayze;Bruce S. Ross

  • Conjugated antisense compounds and their use

    Thazha P. Prakash;Punit P. Seth;Eric E. Swayze

  • SAR by MS: Discovery of a New Class of RNA-Binding Small Molecules for the Hepatitis C Virus: Internal Ribosome Entry Site IIA Subdomain

    Punit P. Seth;Alycia Miyaji;Elizabeth A. Jefferson;Kristin A. Sannes-Lowery

  • Compounds and methods for synthesis of bicyclic nucleic acid analogs

    Balkrishen Bhat;Jie Xia;Punit P. Seth;Guillermo Vasquez

  • Compounds and methods for modulating gene expression

    Sanjay Bhanot;Richard S. Geary;Robert Mckay;Brett P. Monia

  • Targeted delivery of antisense oligonucleotides to pancreatic β-cells.

    C. Ämmälä;W. J. Drury;L. Knerr;I. Ahlstedt

  • Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes.

    Michael Tanowitz;Lisa Hettrick;Alexey Revenko;Garth A Kinberger

  • Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

    W. Brad Wan;Michael T. Migawa;Guillermo Vasquez;Heather M. Murray

  • Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver

    Colton M. Miller;Aaron J. Donner;Emma E. Blank;Andrew W. Egger

  • DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing

    Kazutaka Nishina;Wenying Piao;Kie Yoshida-Tanaka;Yumiko Sujino

  • Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay.

    Hans J Gaus;Ruchi Gupta;Alfred E Chappell;Michael E Østergaard

  • Design, Synthesis And Evaluation Of Constrained Methoxyethyl (cMOE) and Constrained Ethyl (cEt) Nucleoside Analogs

    Punit P Seth;Andrew Siwkowski;Charles R Allerson;Guillermo Vasquez

  • Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

    Thazha P Prakash;Adam E Mullick;Richard G Lee;Jinghua Yu

  • Compounds and methods for modulating expression of apob

    ブハノト サンジャイ;Bhanot Sanjay;エス.ゲアリ リチャルド;Richard S Geary

  • Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes

    Thazha P. Prakash;Jinghua Yu;Michael T. Migawa;Garth A. Kinberger

  • Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS

    Tetsuya Nagata;Chrissa A. Dwyer;Kie Yoshida-Tanaka;Kensuke Ihara

  • An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.

    Punit P Seth;Charles R. Allerson;Andres Berdeja;Andrew Siwkowski

  • Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity

    Thazha P. Prakash;Walt F. Lima;Heather M. Murray;Wenyu Li

  • Selective tissue targeting of synthetic nucleic acid drugs

    Punit P. Seth;Michael Tanowitz;C. Frank Bennett

  • Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.

    Brooke A Anderson;Graeme C Freestone;Audrey Low;Cheryl L De-Hoyos

Frequent Co-Authors

Eric E. Swayze
Eric E. Swayze Ionis Pharmaceuticals (United States)
Richard S. Geary
Richard S. Geary Ionis Pharmaceuticals (United States)
Stanley T. Crooke
Stanley T. Crooke Ionis Pharmaceuticals (United States)
C. Frank Bennett
C. Frank Bennett Ionis Pharmaceuticals (United States)
Stephen Hanessian
Stephen Hanessian University of Montreal
Michael R. Hayden
Michael R. Hayden University of British Columbia
Brett P. Monia
Brett P. Monia Ionis Pharmaceuticals (United States)
Frank Rigo
Frank Rigo Ionis Pharmaceuticals (United States)
Martin Egli
Martin Egli Vanderbilt University
Susan M. Freier
Susan M. Freier Ionis Pharmaceuticals (United States)

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