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Neuroscience

D-Index
56
Citations
12768
World Ranking
4485
National Ranking
132

Overview

Takanori Yokota is affiliated with the Institute of Science Tokyo in Japan. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, with particular focus on molecular biology, neurology, and cellular and molecular neuroscience. Their scientific contributions also extend to physiology and pathology and forensic medicine.

The main topics explored in Yokota's body of work include RNA interference and gene delivery, advanced biosensing and bioanalysis techniques, DNA and nucleic acid chemistry, RNA regulation and disease, Parkinson's disease mechanisms and treatments, genetic neurodegenerative diseases, and RNA research and splicing.

Yokota has published in a variety of journals, frequently contributing to Molecular Therapy - Nucleic Acids, Internal Medicine, Neurology, Scientific Reports, and the Journal of the Neurological Sciences.

Among recent papers authored or co-authored by Yokota are the following:

  • Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS, 2021, Nature Biotechnology
  • Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain, 2020, ACS Nano
  • Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease, 2023, Circulation Research
  • Progressive supranuclear palsy often develops idiopathic normal pressure hydrocephalus-like magnetic resonance imaging features, 2020, European Journal of Neurology
  • Amyloid-β oligomers interact with NMDA receptors containing GluN2B subunits and metabotropic glutamate receptor 1 in primary cortical neurons: Relevance to the synapse pathology of Alzheimer's disease, 2022, Neuroscience Research

Yokota has collaborated extensively with other researchers, with frequent co-authors including Tetsuya Nagata, Nobuo Sanjo, Hiroya Kuwahara, Yoichiro Nishida, and Kotaro Yoshioka.

Best Publications

  • Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

    Rammohan V. Rao;Alyson Peel;Anna Logvinova;Gabriel del Rio

  • ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

    Hideki Nishitoh;Hisae Kadowaki;Atsushi Nagai;Takeshi Maruyama

  • Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

    Takanori Yokota;Kanako Sugawara;Kaoru Ito;Ryosuke Takahashi

  • Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol.

    Kazutaka Nishina;Toshinori Unno;Yoshitaka Uno;Takayuki Kubodera

  • Delayed-onset ataxia in mice lacking α-tocopherol transfer protein: Model for neuronal degeneration caused by chronic oxidative stress

    Takanori Yokota;Keiji Igarashi;Toshiki Uchihara;Kou Ichi Jishage

  • Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

    Y. Anraku;H. Kuwahara;Y. Fukusato;A. Mizoguchi

  • Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial

    Ivo N van Schaik;Vera Bril;Nan van Geloven;Hans-Peter Hartung

  • Adult-Onset Spinocerebellar Dysfunction Caused by a Mutation in the Gene for the α-Tocopherol–Transfer Protein

    Takanari Gotoda;Makoto Arita;Hiroyuki Arai;Keizo Inoue

  • Sleep-related periodic leg movements (nocturnal myoclonus) due to spinal cord lesion.

    Takanori Yokota;Kazuhiko Hirose;Hitoshi Tanabe;Hiroshi Tsukagoshi

  • Interferon Regulatory Factor 1 (IRF-1) and IRF-2 Distinctively Up-Regulate Gene Expression and Production of Interleukin-7 in Human Intestinal Epithelial Cells

    Shigeru Oshima;Tetsuya Nakamura;Shin Namiki;Eriko Okada

  • Safety and efficacy of eculizumab in Guillain-Barré syndrome: a multicentre, double-blind, randomised phase 2 trial

    Sonoko Misawa;Satoshi Kuwabara;Yasunori Sato;Nobuko Yamaguchi

  • An Autosomal Dominant Cerebellar Ataxia Linked to Chromosome 16q22.1 Is Associated with a Single-Nucleotide Substitution in the 5′ Untranslated Region of the Gene Encoding a Protein with Spectrin Repeat and Rho Guanine-Nucleotide Exchange-Factor Domains

    Kinya Ishikawa;Shuta Toru;Taiji Tsunemi;Mingshun Li

  • SYMPATHETIC SKIN RESPONSE IN PATIENTS WITH MULTIPLE SCLEROSIS COMPARED WITH PATIENTS WITH SPINAL CORD TRANSECTION AND NORMAL CONTROLS

    Takanori Yokota;Takashi Matsunaga;Ryoichi Okiyama;Kazuhiko Hirose

  • Double cortical stimulation in amyotrophic lateral sclerosis.

    Takanori Yokota;Akiko Yoshino;Akira Inaba;Yukinobu Saito

  • Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation?

    Tadashi Kanouchi;Takuya Ohkubo;Takanori Yokota

  • DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing

    Kazutaka Nishina;Wenying Piao;Kie Yoshida-Tanaka;Yumiko Sujino

  • Friedreich-like ataxia with retinitis pigmentosa caused by the His101Gln mutation of the alpha-tocopherol transfer protein gene.

    Takanori Yokota;Toshiaki Shiojiri;Takanari Gotoda;Makoto Arita

  • Localization of α-tocopherol transfer protein in rat brain

    Akihiro Hosomi;Kaoru Goto;Hisatake Kondo;Takeshi Iwatsubo

  • Depletion of Vitamin E Increases Amyloid β Accumulation by Decreasing Its Clearances from Brain and Blood in a Mouse Model of Alzheimer Disease

    Yoichiro Nishida;Shingo Ito;Sumio Ohtsuki;Naoki Yamamoto

  • Down-regulation of α-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson’s disease rat model ☆

    Hiromi Hayashita-Kinoh;Masanori Yamada;Takanori Yokota;Yoshikuni Mizuno

Frequent Co-Authors

Hidehiro Mizusawa
Hidehiro Mizusawa Tokyo Medical and Dental University
Toshiki Uchihara
Toshiki Uchihara Tokyo Metropolitan Institute of Medical Science
Kazunori Kataoka
Kazunori Kataoka University of Tokyo
Kenji Ishii
Kenji Ishii Nippon Medical School
Hideki Mochizuki
Hideki Mochizuki Osaka University
Shoji Tsuji
Shoji Tsuji University of Tokyo
Gen Sobue
Gen Sobue Aichi Medical University
Jun-ichi Kira
Jun-ichi Kira Kyushu University
Sonoko Misawa
Sonoko Misawa Chiba University
Naomichi Matsumoto
Naomichi Matsumoto Yokohama City University

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