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Hiroyoshi Ariga

Hiroyoshi Ariga

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
16877
World Ranking
7029
National Ranking
472

Overview

Hiroyoshi Ariga is affiliated with Hokkaido University in Japan and works primarily in the fields of Biochemistry, Genetics, and Molecular Biology. Their research focuses extensively on Molecular Biology, with particular attention to RNA-related mechanisms and genetic regulation.

The main topics of their research include:

  • RNA Research and Splicing
  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • Viral Infectious Diseases and Gene Expression in Insects
  • CRISPR and Genetic Engineering

Ariga has coauthored papers with several frequent collaborators, including:

  • Hiroshi Maita
  • Kenji Tomita
  • Shinichi Nakagawa
  • Satoshi Sato

Their research has been published primarily in the Biological and Pharmaceutical Bulletin, where they have contributed at least two papers. These publications illustrate recent work advancing molecular biology assay techniques and understanding of RNA splicing. Selected recent papers include:

  • "BAY61-3606 Alters snRNP Composition and Enhances Usage of Suboptimal Splice Acceptor Site," published in 2023 in Biological and Pharmaceutical Bulletin
  • "Development of a Cell-Based Assay Using a Split-Luciferase Reporter for Compound Screening," published in 2023 in Biological and Pharmaceutical Bulletin

Ariga's research addresses fundamental questions about RNA splicing and modifications, contributing insights into the mechanisms of protein synthesis and the effects of these processes in contexts such as cancer and viral gene expression. The work also extends to the application of genetic engineering technologies including CRISPR.

Best Publications

  • DJ-1 has a role in antioxidative stress to prevent cell death.

    Takahiro Taira;Yoshiro Saito;Takeshi Niki;Sanae M M Iguchi‐Ariga

  • DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras.

    Daisuke Nagakubo;Takahiro Taira;Hirotake Kitaura;Masako Ikeda

  • Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT)

    Satoru Kyo;Masahiro Takakura;Takahiro Taira;Taro Kanaya

  • Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells

    Tomoya Kinumi;Junko Kimata;Junko Kimata;Takahiro Taira;Hiroyoshi Ariga

  • Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

    Takanori Yokota;Kanako Sugawara;Kaoru Ito;Ryosuke Takahashi

  • DJ-1 Positively Regulates the Androgen Receptor by Impairing the Binding of PIASxα to the Receptor

    Kazuko Takahashi;Takahiro Taira;Takeshi Niki;Chiaki Seino

  • Neuroprotective function of DJ-1 in Parkinson's disease.

    Hiroyoshi Ariga;Kazuko Takahashi-Niki;Izumi Kato;Hiroshi Maita

  • Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.

    Masatoshi Inden;Yoshihisa Kitamura;Hiroki Takeuchi;Takashi Yanagida

  • The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease.

    Kazuya Honbou;Nobuo N. Suzuki;Masataka Horiuchi;Takeshi Niki

  • DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.

    Takeshi Niki;Kazuko Takahashi-Niki;Takahiro Taira;Sanae M M Iguchi-Ariga

  • PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson’s disease rat model

    Masatoshi Inden;Takahiro Taira;Yoshihisa Kitamura;Takashi Yanagida

  • DJ-1 binds to mitochondrial complex I and maintains its activity

    Takuya Hayashi;Chikako Ishimori;Kazuko Takahashi-Niki;Takahiro Taira

  • The Slp Homology Domain of Synaptotagmin-like Proteins 1–4 and Slac2 Functions as a Novel Rab27A Binding Domain

    Taruho S. Kuroda;Mitsunori Fukuda;Hiroyoshi Ariga;Katsuhiko Mikoshiba

  • Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities.

    Y Shinbo;T Niki;T Taira;H Ooe

  • Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress

    Hong Mei Li;Takeshi Niki;Takahiro Taira;Sanae M. M. Iguchi-Ariga

  • Induction of Reactive Oxygen Species by Bisphenol A and Abrogation of Bisphenol A-Induced Cell Injury by DJ-1

    Hiromasa Ooe;Takahiro Taira;Sanae M. M. Iguchi-Ariga;Hiroyoshi Ariga

  • Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson’s disease patients

    Kazuko Takahashi-Niki;Takeshi Niki;Takahiro Taira;Sanae M.M Iguchi-Ariga

  • DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3

    Yumi Shinbo;Takahiro Taira;Takeshi Niki;Sanae M.M. Iguchi-Ariga

  • A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus

    Emma C. Ferber;Mihoko Kajita;Anthony Wadlow;Lara Tobiansky

  • Reciprocal regulation via protein-protein interaction between c-Myc and p21(cip1/waf1/sdi1) in DNA replication and transcription.

    Hirotake Kitaura;Minako Shinshi;Yasuko Uchikoshi;Takashi Ono

Frequent Co-Authors

Yoshiro Saito
Yoshiro Saito Tohoku University
Fuyuhiko Inagaki
Fuyuhiko Inagaki Hokkaido University
Takashi Taniguchi
Takashi Taniguchi National Institute for Materials Science
Masataka Kinjo
Masataka Kinjo Hokkaido University
Noriko Noguchi
Noriko Noguchi Doshisha University
Marshall S. Horwitz
Marshall S. Horwitz University of Washington
Ikuo Tooyama
Ikuo Tooyama Shiga University of Medical Science
Shun Shimohama
Shun Shimohama Sapporo Medical University
Hidehiko Sano
Hidehiko Sano Hokkaido University

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