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Neuroscience

D-Index
58
Citations
11799
World Ranking
4173
National Ranking
120

Overview

Ikuo Tooyama is affiliated with Shiga University of Medical Science in Japan. Their research spans multiple fields, with a primary focus on medicine and biochemistry, genetics, and molecular biology. Within these broad areas, Tooyama has contributed notably to physiology, molecular biology, and neurology, while also engaging in studies related to nutrition and dietetics and cell biology.

Tooyama's work addresses several main topics including Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, redox biology and oxidative stress, drug transport and resistance mechanisms, prion diseases and protein misfolding, Parkinson's disease mechanisms and treatments, and endoplasmic reticulum stress and disease.

Frequent publication venues for Tooyama include the International Journal of Molecular Sciences and ACTA HISTOCHEMICA ET CYTOCHEMICA, each hosting five of their papers. Additional journals where Tooyama has published multiple times include Molecules, ACS Chemical Neuroscience, and Biochemical and Biophysical Research Communications.

Notable recent papers authored or co-authored by Tooyama feature titles such as:

  • Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and Neurodegenerative Diseases, 2020, International Journal of Molecular Sciences
  • Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains, 2020, International Journal of Molecular Sciences
  • An insight into the neuroprotective and anti-neuroinflammatory effects and mechanisms of Moringa oleifera, 2023, Frontiers in Pharmacology
  • A Mechanistic Evaluation of Antioxidant Nutraceuticals on Their Potential against Age-Associated Neurodegenerative Diseases, 2020, Antioxidants
  • Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein, 2020, Journal of Alzheimer s Disease

Tooyama has collaborated frequently with colleagues in their field. Among the most common co-authors are Daijiro Yanagisawa, with 28 joint works; Zulzikry Hafiz Abu Bakar, with 10; Tomoko Kato, with 9; Douglas G. Walker, with 8; and Aya Kadota, also with 8 joint publications.

Best Publications

  • Microglia in degenerative neurological disease

    Patrick L. McGeer;Toshio Kawamata;Douglas G. Walker;Haruhiko Akiyama

  • Human positron emission tomographic [18F]Fluorodopa studies correlate with dopamine cell counts and levels

    B. J. Snow;I. Tooyama;I. Tooyama;E. G. McGeer;T. Yamada

  • Reduced Neuron-Specific Expression of the TAF1 Gene Is Associated with X-Linked Dystonia-Parkinsonism

    Satoshi Makino;Satoshi Makino;Ryuji Kaji;Satoshi Ando;Satoshi Ando;Maiko Tomizawa

  • Enhancement of progenitor cell division in the dentate gyrus triggered by initial limbic seizures in rat models of epilepsy.

    Eiji Nakagawa;Yoshinari Aimi;Osamu Yasuhara;Ikuo Tooyama

  • Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease

    I. Tooyama;H. Kimura;H. Akiyama;P.L. McGeer

  • Lactotransferrin immunocytochemistry in Alzheimer and normal human brain.

    T Kawamata;I Tooyama;T Yamada;D G Walker

  • Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease.

    I. Moroo;T. Yamada;H. Makino;I. Tooyama

  • Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders

    Haruhiko Akiyama;Toshio Kawamata;Tatsuo Yamada;Ikuo Tooyama

  • Functional anatomy of the basal ganglia in X-linked recessive dystonia-parkinsonism

    Satoshi Goto;Lillian V. Lee;Edwin L. Munoz;Ikuo Tooyama

  • Relationship between the tautomeric structures of curcumin derivatives and their Aβ-binding activities in the context of therapies for Alzheimer's disease.

    Daijiro Yanagisawa;Nobuaki Shirai;Tomone Amatsubo;Hiroyasu Taguchi

  • Insulin receptor mRNA in the substantia nigra in Parkinson's disease

    Mitsuo Takahashi;Tatsuo Yamada;Ikuo Tooyama;Iku Moroo

  • Loss of basic fibroblast growth factor in substantia nigra neurons in Parkinson's disease

    I. Tooyama;T. Kawamata;D. Walker;T. Yamada

  • Early response of brain resident microglia to kainic acid-induced hippocampal lesions

    Haruhiko Akiyama;Ikuo Tooyama;Hiromi Kondo;Kenji Ikeda

  • Human neural stem cells over-expressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction.

    Dongsun Park;Hong Jun Lee;Hong Jun Lee;Seong Soo Joo;Dae-Kwon Bae

  • Morphological diversities of CD44 positive astrocytes in the cerebral cortex of normal subjects and patients with Alzheimer's disease

    Haruhiko Akiyama;Ikuo Tooyama;Toshio Kawamata;Kenji Ikeda

  • A protein encoded by an alternative splice variant of choline acetyltransferase mRNA is localized preferentially in peripheral nerve cells and fibers.

    Ikuo Tooyama;Hiroshi Kimura

  • Microglial transplantation increases amyloid-β clearance in Alzheimer model rats

    Kazuyuki Takata;Yoshihisa Kitamura;Daijiro Yanagisawa;Shigehiro Morikawa

  • DJ-1 Protects against Neurodegeneration Caused by Focal Cerebral Ischemia and Reperfusion in Rats

    Daijiro Yanagisawa;Yoshihisa Kitamura;Masatoshi Inden;Kazuyuki Takata

  • Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells

    Yoshihisa Kitamura;Takashi Ota;Yasuji Matsuoka;Ikuo Tooyama

  • Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43.

    Makoto Urushitani;Takashi Sato;Takashi Sato;Hitoshi Bamba;Yasuo Hisa

  • Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and Neurodegenerative Diseases.

    Haruka Tsubaki;Ikuo Tooyama;Douglas Gordon Walker

Frequent Co-Authors

Yutaka Oomura
Yutaka Oomura Kyushu University
Kazuo Sasaki
Kazuo Sasaki University of Toyama
Douglas G. Walker
Douglas G. Walker Arizona State University
Edith G. McGeer
Edith G. McGeer University of British Columbia
Takashi Taniguchi
Takashi Taniguchi National Institute for Materials Science
Seung U. Kim
Seung U. Kim University of British Columbia
Kinya Kuriyama
Kinya Kuriyama Kyoto Prefectural University of Medicine
Peter J. Gebicke-Haerter
Peter J. Gebicke-Haerter Heidelberg University
Toshihiro Maeda
Toshihiro Maeda Osaka University

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