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Chemistry

D-Index
64
Citations
21446
World Ranking
7917
National Ranking
528

Overview

Hiroyuki Kagechika is affiliated with Tokyo Medical and Dental University in Japan. Their research spans multiple fields primarily focused on Biochemistry, Genetics and Molecular Biology, with an emphasis on Medicine. Their work covers a range of subfields including Molecular Biology, Materials Chemistry, Cardiology and Cardiovascular Medicine, Organic Chemistry, and Cell Biology.

The scientist's research interests include several specific topics such as:

  • Ion channel regulation and function
  • Cardiac electrophysiology and arrhythmias
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Chemical Synthesis and Analysis
  • Ion Channels and Receptors
  • Estrogen and related hormone effects

Recent papers by Hiroyuki Kagechika include the following publications:

  • A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke, 2021, Nature Communications
  • Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy, 2021, Proceedings of the National Academy of Sciences
  • WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID, 2020, Communications Biology
  • Activation of β2-adrenergic receptor signals suppresses mesenchymal phenotypes of oral squamous cell carcinoma cells, 2020, Cancer Science
  • CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells, 2021, Journal of Biological Chemistry

Hiroyuki Kagechika has collaborated frequently with several co-authors, including:

  • Aya Tanatani
  • Nagomi Kurebayashi
  • Takashi Murayama
  • Shuichi Mori
  • Ko Urushibara

The scientist's work has been published in a variety of venues, with the most frequent publication venues being:

  • The Cambridge Structural Database
  • Proceedings for Annual Meeting of The Japanese Pharmacological Society
  • Biophysical Journal
  • The Journal of Organic Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)

In the realm of book publications, Hiroyuki Kagechika has contributed to works published by IntechOpen, including "Vitamin K - Recent Topics on the Biology and Chemistry" in 2021.

Best Publications

  • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

    T. Yamauchi;J. Kamon;H. Waki;Y. Terauchi

  • Retinoic Acid Imprints Gut-Homing Specificity on T Cells

    Makoto Iwata;Asami Hirakiyama;Yuko Eshima;Hiroyuki Kagechika

  • Retinoid X receptor gamma signaling accelerates CNS remyelination

    Jeffrey K Huang;Andrew A Jarjour;Brahim Nait Oumesmar;Christophe Kerninon

  • Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.

    Takayuki Shindo;Ichiro Manabe;Yasushi Fukushima;Kazuyuki Tobe

  • Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors

    Makoto Iwata;Yuko Eshima;Hiroyuki Kagechika

  • Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes

    Toshimasa Yamauchi;Hironori Waki;Junji Kamon;Koji Murakami

  • Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.

    Kagechika H;Kawachi E;Hashimoto Y;Himi T

  • Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.

    Hiroki Umemiya;Hiroshi Fukasawa;Masayuki Ebisawa;Laurence Eyrolles

  • Stereochemistry of N-methylbenzanilide and benzanilide

    Akiko Itai;Yoshiharu Toriumi;Nobuo Tomioka;Hiroyuki Kagechika

  • Synthetic retinoids: recent developments concerning structure and clinical utility.

    Hiroyuki Kagechika;Koichi Shudo

  • Preference for cis-amide structure in N-acyl-N-methylanilines

    Akiko Itai;Yoshiharu Toriumi;Shoichi Saito;Hiroyuki Kagechika

  • Aromatic architecture. Use of the N-methylamide structure as a molecular splint

    Kentaro Yamaguchi;Go Matsumura;Hiroyuki Kagechika;Isao Azumaya

  • Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes

    Cécile Calléja;Nadia Messaddeq;Benoit Chapellier;Haiyuan Yang

  • Twisted intramolecular charge-transfer fluorescence of aromatic amides: conformation of the amide bonds in excited states

    Isao Azumaya;Hiroyuki Kagechika;Yoshihisa Fujiwara;Michiya Itoh

  • All-trans Retinoic Acid Induces in Vitro Angiogenesis via Retinoic Acid Receptor: Possible Involvement of Paracrine Effects of Endogenous Vascular Endothelial Growth Factor Signaling

    Akiko Saito;Akira Sugawara;Akira Uruno;Masataka Kudo

  • A MUTATION MIMICKING LIGAND-INDUCED CONFORMATIONAL CHANGE YIELDS A CONSTITUTIVE RXR THAT SENSES ALLOSTERIC EFFECTS IN HETERODIMERS

    Valerie Vivat;Christina Zechel;Jean‐Marie Wurtz;William Bourguet

  • Identification of a Novel Class of Retinoic Acid Receptor β-Selective Retinoid Antagonists and Their Inhibitory Effects on AP-1 Activity and Retinoic Acid-induced Apoptosis in Human Breast Cancer Cells

    Yin Li;Yuichi Hashimoto;Anissa Agadir;Hiroyuki Kagechika

  • MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells.

    Eduardo J. Villablanca;Sen Wang;Jaime de Calisto;Jaime de Calisto;Daniel C.O. Gomes

  • Boron Cluster-based Development of Potent Nonsecosteroidal Vitamin D Receptor Ligands: Direct Observation of Hydrophobic Interaction between Protein Surface and Carborane

    Shinya Fujii;Hiroyuki Masuno;Yoshiyuki Taoda;Atsushi Kano

  • Retinobenzoic acids. 3. Structure-activity relationships of retinoidal azobenzene-4-carboxylic acids and stilbene-4-carboxylic acids.

    Hiroyuki Kagechika;Toshiyuki Himi;Koushi Namikawa;Emiko Kawachi

  • Novel synthetic retinoids and separation of the pleiotropic retinoidal activities.

    Hiroyuki Kagechika

Frequent Co-Authors

Koichi Shudo
Koichi Shudo University of Tokyo
Yuichi Hashimoto
Yuichi Hashimoto University of Tokyo
Kentaro Yamaguchi
Kentaro Yamaguchi Tokushima Bunri University
Yutaka Hata
Yutaka Hata Tokyo Medical and Dental University
Hiroshi Nishina
Hiroshi Nishina Tokyo Medical and Dental University
Ryozo Nagai
Ryozo Nagai Jichi Medical University
Ichiro Manabe
Ichiro Manabe Chiba University
Masanobu Uchiyama
Masanobu Uchiyama University of Tokyo
Li-Na Wei
Li-Na Wei University of Minnesota
Shinichi Uchida
Shinichi Uchida Tokyo Medical and Dental University

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