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Yoshiro Saito

Yoshiro Saito

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
23046
World Ranking
3906
National Ranking
253

Overview

Yoshiro Saito is affiliated with Tohoku University in Japan and has contributed to research spanning medicine and biochemistry, genetics, and molecular biology. Their work encompasses molecular biology, pharmacology, immunology, oncology, and biomedical engineering.

Their research focuses on several main topics, including:

  • Biosimilars and bioanalytical methods
  • Pharmacogenetics and drug metabolism
  • Drug transport and resistance mechanisms
  • Drug-induced adverse reactions
  • Drug-induced hepatotoxicity and protection
  • Animal testing and alternatives
  • Protein purification and stability

Yoshiro Saito has coauthored numerous papers with several frequent collaborators. Notable frequent coauthors include Kosuke Saito, Akiko Ishii-Watabe, Yoïchi Tanaka, Noriaki Arakawa, and Ryosuke Nakamura.

Common publication venues for their work are:

  • Bioanalysis
  • Drug Metabolism and Pharmacokinetics
  • Biological and Pharmaceutical Bulletin
  • The Journal of Toxicological Sciences
  • Hepatology Research

Among recent papers, several relevant publications include:

  • Association of HLA-A*11:01 with Sulfonamide-Related Severe Cutaneous Adverse Reactions in Japanese Patients, 2020, Journal of Investigative Dermatology
  • Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage, 2022, Nature Communications
  • 2020 White Paper on Recent Issues in Bioanalysis: BAV Guidance, CLSI H62, Biotherapeutics Stability, Parallelism Testing, CyTOF and Regulatory Feedback (Part 2A - Recommendations on Biotherapeutics Stability, PK LBA Regulated Bioanalysis, Biomarkers Assays, Cytometry Validation & Innovation Part 2B - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine), 2021, Bioanalysis
  • 2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Endogenous Compounds, Small Molecules, Complex Methods, Regulated Mass Spec of Large Molecules, Small Molecule, PoC & Part 1B - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine), 2022, Bioanalysis
  • Identification and characterization of lysophosphatidylcholine 14:0 as a biomarker for drug-induced lung disease, 2022, Scientific Reports

Best Publications

  • Lipid peroxidation: mechanisms, inhibition, and biological effects.

    Etsuo Niki;Yasukazu Yoshida;Yoshiro Saito;Noriko Noguchi

  • DJ-1 has a role in antioxidative stress to prevent cell death.

    Takahiro Taira;Yoshiro Saito;Takeshi Niki;Sanae M M Iguchi‐Ariga

  • A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance

    Hirofumi Misu;Toshinari Takamura;Hiroaki Takayama;Hiroto Hayashi

  • HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis.

    Nahoko Kaniwa;Yoshiro Saito;Michiko Aihara;Kayoko Matsunaga

  • A comparative study on the hydroperoxide and thiol specificity of the glutathione peroxidase family and selenoprotein P.

    Gen Takebe;Junko Yarimizu;Yoshiro Saito;Takaaki Hayashi

  • Protein Adsorption of Ultrafine Metal Oxide and Its Influence on Cytotoxicity toward Cultured Cells

    Masanori Horie;Keiko Nishio;Katsuhide Fujita;Shigehisa Endoh

  • Cell death caused by selenium deficiency and protective effect of antioxidants

    Yoshiro Saito;Yasukazu Yoshida;Takashi Akazawa;Kazuhiko Takahashi

  • Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28.

    Hironobu Minami;Kimie Sai;Mayumi Saeki;Yoshiro Saito

  • Selenoprotein P in Human Plasma as an Extracellular Phospholipid Hydroperoxide Glutathione Peroxidase ISOLATION AND ENZYMATIC CHARACTERIZATION OF HUMAN SELENOPROTEIN P

    Yoshiro Saito;Takaaki Hayashi;Ayako Tanaka;Yasuko Watanabe

  • UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer.

    Kimie Sai;Mayumi Saeki;Yoshiro Saito;Shogo Ozawa

  • Population Differences in Major Functional Polymorphisms of Pharmacokinetics/pharmacodynamics-related Genes in Eastern Asians and Europeans: Implications in the Clinical Trials for Novel Drug Development

    Kouichi Kurose;Emiko Sugiyama;Yoshiro Saito

  • HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.

    Nahoko Kaniwa;Yoshiro Saito;Michiko Aihara;Kayoko Matsunaga

  • Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population.

    Hiromi Fukushima-Uesaka;Yoshiro Saito;Hidemi Watanabe;Kisho Shiseki

  • Turning point in apoptosis/necrosis induced by hydrogen peroxide.

    Yoshiro Saito;Keiko Nishio;Yoko Ogawa;Junko Kimata

  • 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2.

    Zhi Hua Chen;Yoshiro Saito;Yasukazu Yoshida;Azusa Sekine

  • Pharmacokinetics of Gemcitabine in Japanese Cancer Patients: The Impact of a Cytidine Deaminase Polymorphism

    Emiko Sugiyama;Nahoko Kaniwa;Su-Ryang Kim;Ruri Kikura-Hanajiri

  • Racial variability in haplotype frequencies of UGT1A1 and glucuronidation activity of a novel single nucleotide polymorphism 686C> T (P229L) found in an African-American.

    Nahoko Kaniwa;Kouichi Kurose;Hideto Jinno;Toshiko Tanaka-Kagawa

  • Characterization of selenoprotein P as a selenium supply protein

    Yoshiro Saito;Kazuhiko Takahashi

  • Ethnic Differences in Genetic Polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1

    Shogo Ozawa;Akiko Soyama;Mayumi Saeki;Hiromi Fukushima-Uesaka

  • A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients

    M Tohkin;N Kaniwa;Y Saito;E Sugiyama

Frequent Co-Authors

Jun-ichi Sawada
Jun-ichi Sawada University of Shizuoka
Noriko Noguchi
Noriko Noguchi Doshisha University
Shogo Ozawa
Shogo Ozawa Iwate Medical University
Yasukazu Yoshida
Yasukazu Yoshida National Institute of Advanced Industrial Science and Technology
Teruhiko Yoshida
Teruhiko Yoshida National Cancer Research Institute, UK
Nagahiro Saijo
Nagahiro Saijo AstraZeneca (United Kingdom)
Naoyuki Kamatani
Naoyuki Kamatani StaGen (Japan)
Atsushi Ohtsu
Atsushi Ohtsu Juntendo University
Shiro Kamakura
Shiro Kamakura National Cardiovascular Research Center
Tomohide Tamura
Tomohide Tamura St. Luke's International Hospital

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