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2025
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Biology and Biochemistry
Germany
2026

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Best Scientists

D-Index
167
Citations
128363
World Ranking
963
National Ranking
45

Biology and Biochemistry

D-Index
168
Citations
133137
World Ranking
95
National Ranking
6

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2022 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2000 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Biochemistry and Biophysics

Overview

Helmut Sies is affiliated with Heinrich Heine University Düsseldorf in Germany and has made substantial contributions in the fields of biochemistry, genetics, and molecular biology. Their research primarily focuses on redox biology and oxidative stress, covering topics such as free radicals and antioxidants, vitamin C and antioxidants research, gout, hyperuricemia, uric acid, plant toxicity and pharmacological properties, glutathione transferases and polymorphisms, and genomics, phytochemicals, and oxidative stress.

The scientist has published extensively, with papers appearing frequently in journals like Free Radical Biology and Medicine, Nature Reviews Molecular Cell Biology, Redox Biology, BIOspektrum, and Nature Metabolism.

Recent significant publications include:

  • Fundamentals of redox regulation in biology, 2024, Nature Reviews Molecular Cell Biology
  • Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology, 2022, Nature Reviews Molecular Cell Biology
  • Oxidative eustress: On constant alert for redox homeostasis, 2021, Redox Biology
  • Reactive oxygen species (ROS) as pleiotropic physiological signalling agents, 2020, Nature Reviews Molecular Cell Biology
  • Oxidative Stress: Concept and Some Practical Aspects, 2020, Antioxidants

Their work often involves collaboration with recurring coauthors including Michael J. Davies, Giovanni E. Mann, Willem H. Koppenol, Kelvin J.A. Davies, and Barry Halliwell.

Helmut Sies's main research areas span molecular biology, organic chemistry, nutrition and dietetics, biochemistry, and physiology. This multidisciplinary approach facilitates investigations into the biochemical pathways and physiological roles of oxidative stress and redox regulation.

In recognition of their scientific contributions, Helmut Sies was inducted into the German National Academy of Sciences Leopoldina in 2000.

Best Publications

  • Hydroperoxide metabolism in mammalian organs.

    B Chance;H Sies;A Boveris

  • Oxidative stress: oxidants and antioxidants

    H Sies

  • Reactive oxygen species (ROS) as pleiotropic physiological signalling agents.

    Helmut Sies;Dean P. Jones

  • Lycopene as the most efficient biological carotenoid singlet oxygen quencher.

    P Di Mascio;S Kaiser;H Sies

  • Strategies of antioxidant defense

    Helmut Sies

  • Oxidative stress: a concept in redox biology and medicine.

    Helmut Sies

  • Glutathione and its role in cellular functions.

    Helmut Sies

  • Oxidative stress: from basic research to clinical application.

    Helmut Sies

  • Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples.

    Theodorus P.M. Akerboom;Helmut Sies

  • Chemistry of biologically important synthetic organoselenium compounds.

    Mugesh G;du Mont Ww;Sies H

  • Biochemistry of oxidative stress

    Helmut Sies

  • Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress.

    Helmut Sies

  • Vitamins E and C, beta-carotene, and other carotenoids as antioxidants.

    H Sies;W Stahl

  • Antioxidant activity of carotenoids.

    Wilhelm Stahl;Helmut Sies

  • (–)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans

    Hagen Schroeter;Christian Heiss;Christian Heiss;Jan Balzer;Petra Kleinbongard

  • Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols.

    P Di Mascio;M E Murphy;H Sies

  • Bioactivity and protective effects of natural carotenoids.

    Wilhelm Stahl;Helmut Sies

  • Antioxidant Functions of Vitamins

    Helmut Sies;Wilhelm Stahl;Alfred R. Sundquist

  • A novel biologically active seleno-organic compound--I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen).

    Armin Müller;Enrique Cadenas;Peter Graf;Helmut Sies

  • Lycopene: A Biologically Important Carotenoid for Humans?

    Wilhelm Stahl;Helmut Sies

Frequent Co-Authors

Wilhelm Stahl
Wilhelm Stahl Heinrich Heine University Düsseldorf
Karlis Briviba
Karlis Briviba Heinrich Heine University Düsseldorf
Lars-Oliver Klotz
Lars-Oliver Klotz Friedrich Schiller University Jena
Enrique Cadenas
Enrique Cadenas University of Southern California
Wolfgang A. Schulz
Wolfgang A. Schulz Heinrich Heine University Düsseldorf
Dieter Häussinger
Dieter Häussinger Heinrich Heine University Düsseldorf
Albrecht Wendel
Albrecht Wendel University of Konstanz
Paolo Di Mascio
Paolo Di Mascio Universidade de São Paulo
Patrizia Mecocci
Patrizia Mecocci University of Perugia
Herbert de Groot
Herbert de Groot Heinrich Heine University Düsseldorf

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