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D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
32837
World Ranking
7225
National Ranking
3312

Overview

Philip D. Jeffrey is affiliated with Princeton University in the United States and has contributed extensively to the fields of Materials Science and Biochemistry, Genetics and Molecular Biology. Their research spans a variety of subfields including Materials Chemistry, Molecular Biology, Cell Biology, Organic Chemistry, and Renewable Energy, Sustainability and the Environment.

The scientist's work addresses several main topics, with notable focus on Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, Cellular transport and secretion, Photosynthetic Processes and Mechanisms, Lipid Membrane Structure and Behavior, Microtubule and mitosis dynamics, as well as Algal biology and biofuel production.

Philip D. Jeffrey has published papers in a range of scientific venues. The most frequent publication venues include The Cambridge Structural Database, bioRxiv (Cold Spring Harbor Laboratory), Journal of the American Chemical Society, British Journal of Pharmacology, and Nature.

Recent papers authored or co-authored by Philip D. Jeffrey include the following:

  • The structural basis of Rubisco phase separation in the pyrenoid, 2020, Nature Plants
  • The human microbiome encodes resistance to the antidiabetic drug acarbose, 2021, Nature
  • Structure-Reactivity Relationships of Buchwald-Type Phosphines in Nickel-Catalyzed Cross-Couplings, 2022, Journal of the American Chemical Society
  • Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein-Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production, 2021, ACS Chemical Biology
  • Singly Reduced Iridium Chromophores: Synthesis, Characterization, and Photochemistry, 2023, Journal of the American Chemical Society

Frequent collaborators in research with Philip D. Jeffrey include:

  • Gregory D. Scholes
  • Adam Reinhold
  • Robert R. Knowles
  • Yunjung Baek
  • Lei Tian

Best Publications

  • Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations

    Yunje Cho;Svetlana Gorina;Philip D. Jeffrey;Nikola P. Pavletich

  • Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

    Philip D. Jeffrey;Alicia A. Russo;Kornelia Polyak;Emma Gibbs

  • Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.

    Ning Zheng;Brenda A. Schulman;Brenda A. Schulman;Langzhou Song;Julie J. Miller

  • Structural basis for inhibition of the epidermal growth factor receptor by cetuximab

    Shiqing Li;Karl R. Schmitz;Karl R. Schmitz;Philip D. Jeffrey;Jed J.W. Wiltzius

  • Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.

    Alicia A. Russo;Philip D. Jeffrey;Andrea K. Patten;Joan Massagué

  • Structure of a c-Cbl–UbcH7 Complex: RING Domain Function in Ubiquitin-Protein Ligases

    Ning Zheng;Ping Wang;Philip D. Jeffrey;Nikola P. Pavletich

  • Acquired Resistance to Imatinib in Gastrointestinal Stromal Tumor Occurs Through Secondary Gene Mutation

    Cristina R. Antonescu;Peter Besmer;Tianhua Guo;Knarik Arkun

  • BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

    Haijuan Yang;Philip D. Jeffrey;Julie Miller;Elspeth Kinnucan

  • Structural basis of cyclin-dependent kinase activation by phosphorylation.

    Alicia A. Russo;Philip D. Jeffrey;Nikola P. Pavletich

  • Crystal Structure of the Tetramerization Domain of the p53 Tumor Suppressor at 1.7 Angstroms

    Philip D. Jeffrey;Svetlana Gorina;Nikola P. Pavletich

  • Structure of a β-TrCP1-Skp1-β-Catenin Complex: Destruction Motif Binding and Lysine Specificity of the SCFβ-TrCP1 Ubiquitin Ligase

    Geng Wu;Guozhou Xu;Brenda A. Schulman;Philip D. Jeffrey

  • Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.

    Brenda A. Schulman;Andrea C. Carrano;Philip D. Jeffrey;Zachary Bowen

  • Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein

    Adam Oberstein;Philip D. Jeffrey;Yigong Shi

  • Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.

    Alicia A. Russo;Lily Tong;Jie-Oh Lee;Philip D. Jeffrey

  • Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms

    Yan Xu;Liang Feng;Philip D. Jeffrey;Yigong Shi

  • Structure of the Protein Phosphatase 2A Holoenzyme.

    Yanhui Xu;Yongna Xing;Yu Chen;Yang Chao

  • BET inhibitor resistance emerges from leukaemia stem cells

    Chun Yew Fong;Omer Gilan;Omer Gilan;Enid Y N Lam;Alan Rubin

  • Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.

    Andrea Scrima;Renata Koníčková;Bryan K. Czyzewski;Yusuke Kawasaki

  • Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14

    Min Hu;Pingwei Li;Ling Song;Philip D Jeffrey

  • Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins

    Yongna Xing;Yanhui Xu;Yu Chen;Philip D. Jeffrey

Frequent Co-Authors

Yigong Shi
Yigong Shi Westlake University
Frederick M. Hughson
Frederick M. Hughson Princeton University
Nikola P. Pavletich
Nikola P. Pavletich Memorial Sloan Kettering Cancer Center
Bonnie L. Bassler
Bonnie L. Bassler Princeton University
Yanhui Xu
Yanhui Xu Shanghai Medical College of Fudan University
Yu Chen
Yu Chen Memorial Sloan Kettering Cancer Center
Thanos D. Halazonetis
Thanos D. Halazonetis University of Geneva
Brenda A. Schulman
Brenda A. Schulman Max Planck Society
Yu Chen
Yu Chen New York University
Jun Yu
Jun Yu Chinese University of Hong Kong

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