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Biology and Biochemistry
China
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
128
Citations
74413
World Ranking
441
National Ranking
8

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in China Leader Award
  • 2025 - Research.com Biology and Biochemistry in China Leader Award
  • 2023 - Research.com Biology and Biochemistry in China Leader Award
  • 2022 - Research.com Biology and Biochemistry in China Leader Award

Overview

Yigong Shi is affiliated with Westlake University in China and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology. Their scholarly output includes publications in subfields such as Physiology, Biomedical Engineering, Structural Biology, and Immunology.

Their research topics encompass a range of areas with significant coverage in RNA Research and Splicing, RNA modifications and cancer, RNA and protein synthesis mechanisms, and Nuclear Structure and Function. Additional thematic interests include Advanced Electron Microscopy Techniques and Applications, Alzheimer's disease research and treatments, and the study of Electromagnetic Fields and Biological Effects.

Yigong Shi's recent papers include the following publications:

  • "Molecular Architecture of the SARS-CoV-2 Virus," 2020, Cell
  • "Structural and functional diversity calls for a new classification of ABC transporters," 2020, FEBS Letters
  • "Structural basis of γ-secretase inhibition and modulation by small molecule drugs," 2020, Cell
  • "Specific electromagnetic radiation in the wireless signal range increases wakefulness in mice," 2021, Proceedings of the National Academy of Sciences
  • "Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases," 2020, Molecular Cell

Some of the frequent coauthors collaborating with Yigong Shi are Jianlin Lei, Chuangye Yan, Gaoxingyu Huang, Xiechao Zhan, and Yanyu Zhao.

Their publications often appear in prominent scientific venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Science
  • Cell Research
  • Nature Communications

Best Publications

  • Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

    Yigong Shi;Joan Massagué

  • Integrated genomic analyses of ovarian carcinoma

    D. Bell;A. Berchuck;M. Birrer;J. Chien

  • Molecular mechanisms of caspase regulation during apoptosis

    Stefan J. Riedl;Yigong Shi

  • The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc

    Jeremy M. Berg;Yigong Shi

  • Mechanisms of Caspase Activation and Inhibition during Apoptosis

    Yigong Shi

  • Serine/Threonine Phosphatases: Mechanism through Structure

    Yigong Shi

  • A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

    Srinivasa M. Srinivasula;Ramesh Hegde;Ayman Saleh;Pinaki Datta

  • Crystal Structure of the PTEN Tumor Suppressor: Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association

    J.-O. Lee;Haijuan Yang;M.-M. Georgescu;A. Di Cristofano

  • Structural and biochemical basis of apoptotic activation by Smac/DIABLO.

    Jijie Chai;Chunying Du;Jia-Wei Wu;Saw Kyin

  • Structural basis of IAP recognition by Smac/DIABLO

    Geng Wu;Jijie Chai;Tomeka L. Suber;Jia-Wei Wu

  • Molecular Architecture of the SARS-CoV-2 Virus

    Hangping Yao;Yutong Song;Yong Chen;Nanping Wu

  • Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.

    Yigong Shi;Yan-Fei Wang;Lata Jayaraman;Haijuan Yang

  • Mechanism of XIAP-Mediated Inhibition of Caspase-9

    Eric N Shiozaki;Jijie Chai;Daniel J Rigotti;Stefan J Riedl

  • Structural Basis of Caspase-7 Inhibition by XIAP

    Jijie Chai;Eric Shiozaki;Srinivasa M. Srinivasula;Qi Wu

  • Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors

    Dong Deng;Chuangye Yan;Xiaojing Pan;Magdy M. Mahfouz

  • Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde

    Min Hu;Pingwei Li;Muyang Li;Wenyu Li

  • Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein

    Adam Oberstein;Philip D. Jeffrey;Yigong Shi

  • A structural basis for mutational inactivation of the tumour suppressor Smad4.

    Yigong Shi;Akiko Hata;Roger S. Lo;Joan Massagué

  • Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms

    Yan Xu;Liang Feng;Philip D. Jeffrey;Yigong Shi

  • PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling

    Xia Lin;Xueyan Duan;Yao Yun Liang;Ying Su

Frequent Co-Authors

Chuangye Yan
Chuangye Yan Tsinghua University
Nieng Yan
Nieng Yan Princeton University
Jianlin Lei
Jianlin Lei Tsinghua University
Jijie Chai
Jijie Chai Westlake University
Philip D. Jeffrey
Philip D. Jeffrey Princeton University
Yanhui Xu
Yanhui Xu Shanghai Medical College of Fudan University
Srinivasa M. Srinivasula
Srinivasa M. Srinivasula Indian Institute of Science Education and Research, Thiruvananthapuram
Emad S. Alnemri
Emad S. Alnemri Thomas Jefferson University
Joan Massagué
Joan Massagué Memorial Sloan Kettering Cancer Center
Ding Xue
Ding Xue University of Colorado Boulder

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