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D-Index & Metrics

Chemistry

D-Index
40
Citations
5167
World Ranking
17922
National Ranking
799

Overview

Eric Defrancq is affiliated with Grenoble Alpes University in France and has a research focus within the field of Biochemistry, Genetics and Molecular Biology, with notable contributions across related subfields including Molecular Biology, Materials Chemistry, Radiology, Nuclear Medicine and Imaging, Oncology, and Bioengineering.

Their recent scholarly output includes several publications from 2020 and 2021 covering various aspects of molecular interactions and biochemical mechanisms. Key papers include:

  • Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands, 2021, eLife
  • Negative SPR Signals during Low Molecular Weight Analyte Recognition, 2021, Analytical Chemistry
  • Constrained G4 structures unveil topology specificity of known and new G4 binding proteins, 2021, Scientific Reports
  • Flexible RuII Schiff Base Complexes: G-Quadruplex DNA Binding and Photo-Induced Cancer Cell Death, 2020, Chemistry - A European Journal
  • Direct Detection of Low-Molecular-Weight Compounds in 2D and 3D Aptasensors by Biolayer Interferometry, 2020, ACS Sensors

The frequent coauthors collaborating with the scientist include Jérôme Dejeu, Hugues Bonnet, Dennis Gómez, Thomas Lavergne, and Joseph Boissieras.

Defrancq publishes regularly in venues such as bioRxiv (Cold Spring Harbor Laboratory), The Cambridge Structural Database, Chemistry - A European Journal, Organic & Biomolecular Chemistry, and Comptes Rendus Chimie.

Their research topics cover a wide range of specialized areas assembled as:

  • Advanced biosensing and bioanalysis techniques
  • DNA and Nucleic Acid Chemistry
  • RNA Interference and Gene Delivery
  • RNA and protein synthesis mechanisms
  • Advanced Biosensing Techniques and Applications
  • Monoclonal and Polyclonal Antibodies Research
  • Crystallization and Solubility Studies

Best Publications

  • Methods for investigating G-quadruplex DNA/ligand interactions

    Pierre Murat;Yashveer Singh;Eric Defrancq

  • Recent developments in oligonucleotide conjugation

    Yashveer Singh;Pierre Murat;Eric Defrancq

  • Highly efficient synthesis of peptide-oligonucleotide conjugates: chemoselective oxime and thiazolidine formation.

    Damien Forget;Didier Boturyn;Eric Defrancq;Jean Lhomme

  • Preparation of a Multitopic Glycopeptide−Oligonucleotide Conjugate

    Yashveer Singh;Olivier Renaudet;Eric Defrancq;Pascal Dumy

  • Label-free femtomolar detection of target DNA by impedimetric DNA sensor based on poly(pyrrole-nitrilotriacetic acid) film.

    Jessica Baur;Chantal Gondran;Michael Holzinger;Eric Defrancq

  • Improvement of porphyrins for G-quadruplex DNA targeting.

    Carmen Romera;Oriane Bombarde;Romaric Bonnet;Dennis Gomez

  • Plasmon-induced CD response of oligonucleotide-conjugated metal nanoparticles.

    Valérie A. Gérard;Yurii K. Gun'ko;Eric Defrancq;Alexander O. Govorov

  • Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands.

    Madeleine Bossaert;Angélique Pipier;Jean-Francois Riou;Céline Noirot

  • Ru‐Labeled Oligonucleotides for Photoinduced Reactions on Targeted DNA Guanines

    I. Ortmans;N. Boutonnet;A. Kirsch-De Mesmaeker

  • RAFT Nano-constructs: surfing to biological applications.

    Didier Boturyn;Eric Defrancq;Gunnar T. Dolphin;Julian Garcia

  • Ru(II) complexes and light: molecular tools for biomolecules

    Leslie Herman;Sumana Ghosh;Eric Defrancq;Andrée Kirsch-De Mesmaekera

  • Electrogenerated trisbipyridyl Ru(II)-/nitrilotriacetic-polypyrene copolymer for the easy fabrication of label-free photoelectrochemical immunosensor and aptasensor: Application to the determination of thrombin and anti-cholera toxinantibody

    Yao Wenjuan;Yao Wenjuan;Alan Le Goff;Nicolas Spinelli;Michael Holzinger

  • Synthesis of fluorescent probes for the detection of abasic sites in DNA

    Didier Boturyn;Ali Boudali;Jean-François Constant;Eric Defrancq

  • Glycoclusters on oligonucleotide and PNA scaffolds: synthesis and applications.

    Nicolas Spinelli;Eric Defrancq;François Morvan

  • Label-free impedimetric thrombin sensor based on poly(pyrrole-nitrilotriacetic acid)-aptamer film

    Hui Xu;Karine Gorgy;Chantal Gondran;Alan Le Goff

  • Template-assembled synthetic G-quadruplex (TASQ): a useful system for investigating the interactions of ligands with constrained quadruplex topologies.

    Pierre Murat;Romaric Bonnet;Angéline Van der Heyden;Nicolas Spinelli

  • A photoreactive ruthenium(II) complex tethered to a guanine-containing oligonucleotide: a biomolecular tool that behaves as a "seppuku molecule".

    Stéphane Le Gac;Stéphane Rickling;Pascal Gerbaux;Eric Defrancq

  • A new fluorescent probe for sensitive detection of carbonyl compounds : sensitivity improvement and application to environmental water samples

    Stéphan Houdier;Sébastien Perrier;Eric Defrancq;Michel Legrand

  • A functional model of galactose oxidase: catalytic oxidation of primary alcohols with a one-electron oxidized copper(II) complex

    Eric Saint-Aman;Ste′phane Me′nage;Jean-Louis Pierre;Eric Defrancq

  • Oligonucleotide sequential bis-conjugation via click-oxime and click-Huisgen procedures.

    Albert Meyer;Nicolas Spinelli;Pascal Dumy;Jean-Jacques Vasseur

  • Chemical Strategies for Oligonucleotide-Conjugates Synthesis

    E. Defrancq;Y. Singh;N. Spinelli

Frequent Co-Authors

Pascal Dumy
Pascal Dumy École Nationale Supérieure de Chimie de Montpellier
Pierre Labbe
Pierre Labbe Grenoble Alpes University
Serge Cosnier
Serge Cosnier Grenoble Alpes University
Jean-François Riou
Jean-François Riou French National Museum of Natural History
Alan Le Goff
Alan Le Goff Grenoble Alpes University
Martine Raes
Martine Raes University of Namur
Yurii K. Gun'ko
Yurii K. Gun'ko Trinity College Dublin
Jacques Piette
Jacques Piette University of Liège
Michael Holzinger
Michael Holzinger Grenoble Alpes University

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