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Biology and Biochemistry

D-Index
74
Citations
17426
World Ranking
5675
National Ranking
162

Overview

Jean-François Riou is affiliated with the French National Museum of Natural History in France and specializes in Biochemistry, Genetics and Molecular Biology. Their research predominantly focuses on Molecular Biology, while also encompassing topics in Ecology, Evolution, Behavior and Systematics, Aging, and Genetics.

The primary themes of Riou's work include DNA and Nucleic Acid Chemistry, Advanced biosensing and bioanalysis techniques, RNA and protein synthesis mechanisms, Cancer therapeutics and mechanisms, Renal and related cancers, Epigenetics and DNA Methylation, and Bat Biology and Ecology Studies.

Riou's recent publications illustrate a concentrated interest in DNA dynamics and related molecular mechanisms. Notable papers include:

  • "Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands" (2021, eLife)
  • "Constrained G4 structures unveil topology specificity of known and new G4 binding proteins" (2021, Scientific Reports)
  • "Sex-Specific Response to Caloric Restriction After Reproductive Investment in Microcebus murinus: An Integrative Approach" (2020, Frontiers in Physiology)
  • "Transcription-associated topoisomerase activities control DNA-breaks production by G-quadruplex ligands" (2020, bioRxiv (Cold Spring Harbor Laboratory))
  • "Hnf1b renal expression directed by a distal enhancer responsive to Pax8" (2022, Scientific Reports)

Most frequently, Riou has published in Scientific Reports and bioRxiv (Cold Spring Harbor Laboratory), contributing two papers to each venue. Additional publications appear in eLife, Frontiers in Physiology, and Nucleic Acids Research.

Collaborations form an integral part of Riou's scientific contributions. Frequent coauthors include:

  • Angélique Pipier
  • Éric Defrancq
  • Patrick Calsou
  • Sébastien Britton
  • Dennis Gómez

Best Publications

  • Alternative splicing directs the expression of two D2 dopamine receptor isoforms

    Bruno Giros;Pierre Sokoloff;Marie-Pascale Martres;Jean-François Riou

  • Targeting telomeres and telomerase

    Anne De Cian;Laurent Lacroix;Laurent Lacroix;Céline Douarre;Nassima Temime-Smaali

  • Natural and pharmacological regulation of telomerase

    Jean-Louis Mergny;Jean-François Riou;Patrick Mailliet;Marie-Paule Teulade-Fichou

  • Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.

    J. F. Riou;L. Guittat;P. Mailliet;A. Laoui

  • A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres.

    Raphaël Rodriguez;Sebastian Müller;Justin A. Yeoman;Chantal Trentesaux

  • Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis

    Alexandre Djiane;Jean-François Riou;Muriel Umbhauer;Jean-Claude Boucaut

  • The C-terminal cytoplasmic Lys-Thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/β-catenin signalling

    Muriel Umbhauer;Alexandre Djiane;Céline Goisset;Alfredo Penzo-Méndez

  • Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I

    Ferdinand Rossi;Emmanuel Labourier;Thierry Forné;Gilles Divita

  • Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay.

    Jean-Louis Mergny;Laurent Lacroix;Marie-Paule Teulade-Fichou;Candide Hounsou

  • The Bloom's syndrome gene product interacts with topoisomerase III.

    Leonard Wu;Sally L. Davies;Phillip S. North;Hélène Goulaouic

  • Preferential binding of a G-quadruplex ligand to human chromosome ends

    Christine Granotier;Gaëlle Pennarun;Lydia Riou;Françoise Hoffschir

  • Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands.

    Gaëlle Pennarun;Christine Granotier;Laurent R Gauthier;Dennis Gomez

  • Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes

    Florence Koeppel;Jean-François Riou;Abdelazize Laoui;Patrick Mailliet

  • Telomerase downregulation induced by the G‐quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing

    Dennis Gomez;Thibault Lemarteleur;Laurent Lacroix;Patrick Mailliet

  • Stabilization of the c-myc gene promoter quadruplex by specific ligands’ inhibitors of telomerase

    Thibault Lemarteleur;Dennis Gomez;Rajaa Paterski;Eliane Mandine

  • The G-quadruplex Ligand Telomestatin Inhibits POT1 Binding to Telomeric Sequences In vitro and Induces GFP-POT1 Dissociation from Telomeres in Human Cells

    Dennis Gomez;Marie-Françoise O'Donohue;Thomas Wenner;Céline Douarre

  • Preclinical evaluation of docetaxel (Taxotere).

    Lavelle F;Bissery Mc;Combeau C;Riou Jf

  • Telomestatin-induced Telomere Uncapping Is Modulated by POT1 through G-overhang Extension in HT1080 Human Tumor Cells

    Dennis Gomez;Thomas Wenner;Bertrand Brassart;Céline Douarre

  • Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors

    Patricia Vrignaud;Dorothée Sémiond;Pascale Lejeune;Hervé Bouchard

  • G4 motifs affect origin positioning and efficiency in two vertebrate replicators

    Anne‐Laure Valton;Vahideh Hassan‐Zadeh;Vahideh Hassan‐Zadeh;Ingrid Lema;Ingrid Lema;Nicole Boggetto

Frequent Co-Authors

Michel Manfait
Michel Manfait University of Reims Champagne-Ardenne
Marie-Paule Teulade-Fichou
Marie-Paule Teulade-Fichou University of Paris-Saclay
Kazuo Shin-ya
Kazuo Shin-ya National Institute of Advanced Industrial Science and Technology
Martine Sancelme
Martine Sancelme University of Clermont Auvergne
Christian Bailly
Christian Bailly Université Catholique de Louvain
Jamal Tazi
Jamal Tazi University of Montpellier
Doriano Fabbro
Doriano Fabbro Novartis (Switzerland)
Igor Nabiev
Igor Nabiev Moscow Engineering Physics Institute
Thomas J. Meyer
Thomas J. Meyer University of North Carolina at Chapel Hill

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