World's Best Scientists 2026 revealed!

Overview

James Hope is affiliated with One Health in the United Kingdom and works primarily in the fields of Neuroscience and Engineering. Their research covers various subfields including Biomedical Engineering, Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology, and Radiology, Nuclear Medicine, and Imaging.

The scientific output of James Hope includes work on multiple topics in neuroscience and neural engineering, with a focus on optical coherence tomography applications, photoacoustic and ultrasonic imaging, memory and neural mechanisms, muscle activation and electromyography studies, transcranial magnetic stimulation studies, and optical imaging and spectroscopy techniques.

Among recent publications, the following papers illustrate the scope of their research:

  • Brain-wide neural recordings in mice navigating physical spaces enabled by a cranial exoskeleton, 2023, bioRxiv (Cold Spring Harbor Laboratory)
  • Brain-wide neural recordings in mice navigating physical spaces enabled by robotic neural recording headstages, 2024, Nature Methods
  • Modeling the excitation of nerve axons under transcutaneous stimulation, 2023, Computers in Biology and Medicine
  • Optical coherence tomography imaging of evoked neural activity in sciatic nerve of rat, 2021, Journal of Physics D Applied Physics
  • Augmentation of neural activity in peripheral nerve of sheep using 6 kHz subthreshold currents, 2020, Physiological Measurement

James Hope frequently collaborates with a number of co-authors. The most frequent are:

  • Frédérique Vanholsbeeck
  • Travis Beckerle
  • Zoey Viavattine
  • Michael D. Feldkamp
  • Skylar Fausner

The venues where James Hope most frequently publishes include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Methods
  • Computers in Biology and Medicine
  • Journal of Physics D Applied Physics
  • Physiological Measurement

Best Publications

  • PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie

    Wilfred Goldmann;Nora Hunter;Grace Smith;James Foster

  • Natural scrapie in a closed flock of Cheviot sheep occurs only in specific PrP genotypes

    Nora Hunter;Jim Foster;Wilfred Goldmann;M. J. Stear

  • The major polypeptide of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP)

    J. Hope;L. J. D. Morton;C. F. Farquhar;G. Multhaup

  • Two alleles of a neural protein gene linked to scrapie in sheep.

    W Goldmann;N Hunter;J D Foster;J M Salbaum

  • Transmission of bovine spongiform encephalopathy to sheep and goats.

    JD Foster;J Hope;H Fraser

  • Molecular assessment of the potential transmissibilities of BSE and scrapie to humans

    Gregory J. Raymond;James Hope;David A. Kocisko;David A. Kocisko;Suzette A. Priola

  • Different forms of the bovine PrP gene have five or six copies of a short, G-C-rich element within the protein-coding exon.

    Wilfred Goldmann;Nora Hunter;Trevor Martin;Michael Dawson

  • Fibrils from brains of cows with new cattle disease contain scrapie-associated protein

    James Hope;Laura J. D. Reekie;Nora Hunter;Gerd Multhaup

  • A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy.

    Jean C. Manson;Elizabeth Jamieson;Herbert Baybutt;Nadia L. Tuzi

  • Scientific Opinion on the public health hazards to be covered by inspection of meat (swine)

    Olivier Andreoletti;Herbert Budka;Sava Buncic;John D Collins

  • Mice with gene targetted prion protein alterations show that Prnp, Sinc and Prni are congruent

    Richard C. Moore;Richard C. Moore;James Hope;Patricia A. McBride;Irene McConnell

  • Lysosomes as key organelles in the pathogenesis of prion encephalopathies.

    Lajos Laszlo;James Lowe;Tim Self;Nigel Kenward

  • Characterization of 2 '-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion

    Alexandre Rhie;Louise Kirby;Natalie Sayer;Rosanna Wellesley

  • Molecular analysis of ovine prion protein identifies similarities between BSE and an experimental isolate of natural scrapie, CH1641

    J Hope;S C Wood;C R Birkett;Angela Chong

  • The association of a codon 136 PrP gene variant with the occurrence of natural scrapie.

    Nora Hunter;Wilfred Goldmann;G Smith;J Hope

  • Linkage of the scrapie-associated fibril protein (PrP) gene and Sinc using congenic mice and restriction fragment length polymorphism analysis.

    Nora Hunter;James Hope;Irene McConnell;Alan G. Dickinson

  • Site-specific characterization of the N-linked glycans of murine prion protein by high-performance liquid chromatography/electrospray mass spectrometry and exoglycosidase digestions.

    Elaine Stimson;James Hope;and Angela Chong;Alma L. Burlingame

  • Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene.

    Wilfred Goldmann;Nora Hunter;Grace Benson;James D. Foster

  • Linkage of the gene for the scrapie-associated fibril protein (PrP) to the Sip gene in Cheviot sheep.

    N Hunter;J D Foster;A G Dickinson;J Hope

  • Biochemical typing of scrapie strains

    Robert A. Somerville;Angela Chong;Orla U. Mulqueen;Christopher R. Birkett

Frequent Co-Authors

Nora Hunter
Nora Hunter University of Edinburgh
Wilfred Goldmann
Wilfred Goldmann University of Edinburgh
Jean Manson
Jean Manson University of Edinburgh
William James
William James University of Oxford
Ian H. Gilbert
Ian H. Gilbert University of Dundee
Moira E. Bruce
Moira E. Bruce University of Edinburgh
Gerd Multhaup
Gerd Multhaup McGill University
Martin Jeffrey
Martin Jeffrey Animal and Plant Health Agency
Peter T. Lansbury
Peter T. Lansbury Harvard University
Konrad Beyreuther
Konrad Beyreuther Heidelberg University

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