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Biology and Biochemistry

D-Index
51
Citations
11308
World Ranking
17046
National Ranking
1342

Overview

Jean Manson is affiliated with the University of Edinburgh in the United Kingdom. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with significant contributions also in medicine. Within these primary fields, their work has focused on molecular biology, physiology, psychiatry and mental health, public health, environmental and occupational health, and neurology.

The main research topics covered by Jean Manson include prion diseases and protein misfolding, dementia and cognitive impairment research, diet and metabolism studies, nutritional studies and diet, RNA regulation and disease, cerebrovascular and carotid artery diseases, as well as cardiovascular health and disease prevention.

Jean Manson has published several papers recently in various respected journals. Notable recent publications include:

  • Subclinical infection occurs frequently following low dose exposure to prions by blood transfusion, 2022, Scientific Reports
  • Preclinical transmission of prions by blood transfusion is influenced by donor genotype and route of infection, 2021, PLoS Pathogens
  • Development of a sensitive real-time quaking-induced conversion (RT-QuIC) assay for application in prion-infected blood, 2023, PLoS ONE
  • Identification of a homology-independent linchpin domain controlling mouse and bank vole prion protein conversion, 2020, PLoS Pathogens
  • The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia, 2024, Brain Communications

The most frequent venues for Jean Manson's work include PLoS Pathogens, Brain Communications, bioRxiv (Cold Spring Harbor Laboratory), Scientific Reports, and PLoS ONE.

Collaborations have been frequent with several researchers, including:

  • Muhammad Khalid Farooq Salamat
  • Christopher de Wolf
  • A. Richard Alejo Blanco
  • Sandra McCutcheon
  • Ivan Koychev

Best Publications

  • The cellular prion protein binds copper in vivo

    D R Brown;K Qin;J W Herms;A Madlung

  • Altered circadian activity rhythms and sleep in mice devoid of prion protein.

    I Tobler;S E Gaus;T Deboer;P Achermann

  • 129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal.

    J C Manson;A R Clarke;M L Hooper;L Aitchison

  • The prion protein gene: a role in mouse embryogenesis?

    J Manson;J D West;V Thomson;P McBride

  • Predicting susceptibility and incubation time of human-to-human transmission of vCJD

    Matthew T Bishop;P Hart;L Aitchison;Herbert N Baybutt

  • Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein

    Edward T Parkin;Nicole T Watt;Ishrut Hussain;Elizabeth A Eckman

  • PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology.

    Jean C Manson;A.R. Clarke;P A McBride;I. McConnell

  • A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy.

    Jean C. Manson;Elizabeth Jamieson;Herbert Baybutt;Nadia L. Tuzi

  • Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie

    Alex J. Raeber;Richard E. Race;Sebastian Brandner;Suzette A. Priola

  • Mice with gene targetted prion protein alterations show that Prnp, Sinc and Prni are congruent

    Richard C. Moore;Richard C. Moore;James Hope;Patricia A. McBride;Irene McConnell

  • Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons.

    José R. Criado;Manuel Sánchez-Alavez;Bruno Conti;Jeannie L. Giacchino

  • Accumulation of prion protein in the brain that is not associated with transmissible disease.

    Pedro Piccardo;Jean C. Manson;Declan King;Bernardino Ghetti

  • Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein

    Boon Seng Wong;Tong Liu;Ruliang Li;Tao Pan

  • Defining sporadic Creutzfeldt-Jakob disease strains and their transmission properties.

    Matthew T. Bishop;Robert G. Will;Jean C. Manson

  • High Titers of Transmissible Spongiform Encephalopathy Infectivity Associated with Extremely Low Levels of PrPSc in Vivo

    Rona M. Barron;Susan L. Campbell;Declan King;Anne Bellon

  • Changing a single amino acid in the N‐terminus of murine PrP alters TSE incubation time across three species barriers

    Rona M. Barron;Val Thomson;Elizabeth Jamieson;David W. Melton

  • Genetic and environmental factors modify bovine spongiform encephalopathy incubation period in mice

    Katerina Manolakou;Jenny Beaton;Irene McConnell;Christine Farquar

  • A novel erythroid-specific marker of transmissible spongiform encephalopathies.

    Gino Miele;Jean Manson;Michael Clinton

  • T-lymphocyte activation and the cellular form of the prion protein.

    Neil Mabbott;Karen Brown;Jean Manson;Moira Bruce

  • Cellular prion protein regulates -secretase cleavage of the Alzheimer's amyloid precursor protein

    Edward T. Parkin;Nicole T. Watt;Ishrut Hussain;Elizabeth A. Eckman

Frequent Co-Authors

Pedro Piccardo
Pedro Piccardo University of Edinburgh
James W. Ironside
James W. Ironside University of Edinburgh
Mark Head
Mark Head University of Edinburgh
Robert G. Will
Robert G. Will University of Edinburgh
Nora Hunter
Nora Hunter University of Edinburgh
Alan Richard Clarke
Alan Richard Clarke Cardiff University
David W. Melton
David W. Melton University of Edinburgh
Fabrizio Tagliavini
Fabrizio Tagliavini Istituto Neurologico Carlo Besta
Nigel M. Hooper
Nigel M. Hooper Manchester Academic Health Science Centre
Martin H. Groschup
Martin H. Groschup Friedrich-Loeffler-Institut

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