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Molecular Biology

D-Index
56
Citations
11054
World Ranking
2205
National Ranking
175

Overview

David W. Melton is affiliated with the University of Edinburgh in the United Kingdom. Their academic work spans several fields of study, primarily within medicine, with a focus on infectious diseases, epidemiology, and general health professions. They also have research contributions in molecular biology and oncology.

Melton's research extensively covers topics related to HIV/AIDS, drug use, and associated sexual risk behaviors. Specific areas of focus include HIV/AIDS research and interventions, HIV research and treatment, sex work and related social issues, as well as the intersections of homelessness and healthcare. Additionally, the scientist has engaged in work related to CRISPR and genetic engineering techniques and the healthcare impacts of COVID-19.

Their frequent publication venues include:

  • MMWR Morbidity and Mortality Weekly Report
  • AIDS and Behavior
  • JAMA
  • The Journal of Infectious Diseases
  • Cancers

David W. Melton has collaborated regularly with several coauthors, including:

  • Pascale Wortley
  • Conall O'Cleirigh
  • Margaret Vaaler
  • Alia Al-Tayyib
  • Emily Higgins

Selected recent publications by Melton include:

  • Population-Level Health Effects of Involuntary Displacement of People Experiencing Unsheltered Homelessness Who Inject Drugs in US Cities, 2023, published in JAMA
  • HIV Infection and HIV-Associated Behaviors Among Persons Who Inject Drugs - 23 Metropolitan Statistical Areas, United States, 2018, 2021, published in MMWR Morbidity and Mortality Weekly Report
  • Racial, Ethnic, and Gender Disparities in Awareness of Preexposure Prophylaxis Among HIV-Negative Heterosexually Active Adults at Increased Risk for HIV Infection - 23 Urban Areas, United States, 2019, 2021, published in MMWR Morbidity and Mortality Weekly Report
  • Healthcare Access and Utilization Among Persons Who Inject Drugs in Medicaid Expansion and Nonexpansion States: 22 United States Cities, 2018, 2020, published in The Journal of Infectious Diseases
  • Identifying and Overcoming Mechanisms of PARP Inhibitor Resistance in Homologous Recombination Repair-Deficient and Repair-Proficient High Grade Serous Ovarian Cancer Cells, 2020, published in Cancers

Best Publications

  • Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

    Thomas Doetschman;Ronald G. Gregg;Nobuyo Maeda;Martin L. Hooper

  • Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.

    R. C. Moore;I. Y. Lee;G. L. Silverman;P. M. Harrison

  • Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells.

    Simon Thompson;Alan R. Clarke;Angela M. Pow;Martin L. Hooper

  • Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene.

    D W Melton;D S Konecki;J Brennand;C T Caskey

  • Mice with DNA repair gene ( ERCC-1 ) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning

    Jim McWhir;Jim Selfridge;David J. Harrison;Shoshana Squires

  • A new mouse embryonic stem cell line with good germ line contribution and gene targeting frequency.

    Thomas M. Magin;Jim McWhir;David W. Melton

  • A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy.

    Jean C. Manson;Elizabeth Jamieson;Herbert Baybutt;Nadia L. Tuzi

  • Lessons from Keratin 18 Knockout Mice: Formation of Novel Keratin Filaments, Secondary Loss of Keratin 7 and Accumulation of Liver-specific Keratin 8-Positive Aggregates

    Thomas M. Magin;Rolf Schröder;Sabine Leitgeb;Frederique Wanninger

  • Mice with gene targetted prion protein alterations show that Prnp, Sinc and Prni are congruent

    Richard C. Moore;Richard C. Moore;James Hope;Patricia A. McBride;Irene McConnell

  • Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors.

    Y Xu;Thomas Brenn;E R S Brown;V Doherty

  • DNA repair endonuclease ERCC1–XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy

    Ewan M. McNeil;David W. Melton

  • A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination.

    Angel Ramirez;Angustias Page;Alberto Gandarillas;Jennifer Zanet

  • Nucleotide excision repair gene XPD polymorphisms and genetic predisposition to melanoma

    Daniela Tomescu;Gina Kavanagh;Tom Ha;Harry Campbell

  • Expression of the mouse HPRT gene: Deletional analysis of the promoter region of an X-Chromosome linked housekeeping gene

    David W. Melton;Carolanne McEwan;Arthur B. McKie;Angela M. Reid

  • Lack of involvement of nucleotide excision repair gene polymorphisms in colorectal cancer.

    Richard L. Mort;L. Mo;C. McEwan;D. W. Melton

  • 53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin

    Fiona Pryde;Shirin Khalili;Kathryn Robertson;Jim Selfridge

  • Changing a single amino acid in the N‐terminus of murine PrP alters TSE incubation time across three species barriers

    Rona M. Barron;Val Thomson;Elizabeth Jamieson;David W. Melton

  • Gene targeting using a mouse HPRT minigene/HPRT-deficient embryonic stem cell system: inactivation of the mouse ERCC-1 gene.

    Jim Selfridge;Angela M. Pow;Jim McWhir;Thomas M. Magin

  • Cloned cDNA sequences of the hypoxanthine/guanine phosphoribosyltransferase gene from a mouse neuroblastoma cell line found to have amplified genomic sequences.

    J Brennand;A C Chinault;D S Konecki;D W Melton

  • Multiple roles of the ERCC1-XPF endonuclease in DNA repair and resistance to anticancer drugs.

    Kristina Kirschner;David W Melton

Frequent Co-Authors

Jean Manson
Jean Manson University of Edinburgh
Philippa T. K. Saunders
Philippa T. K. Saunders University of Edinburgh
Alan Richard Clarke
Alan Richard Clarke Cardiff University
James W. Ironside
James W. Ironside University of Edinburgh
James Hope
James Hope One Health
Joana Azeredo
Joana Azeredo University of Minho
Mariana Henriques
Mariana Henriques University of Minho
Rosário Oliveira
Rosário Oliveira University of Minho
Man Sun Sy
Man Sun Sy Case Western Reserve University
Harry Campbell
Harry Campbell University of Edinburgh

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