Alan Richard Clarke

Overview

Best Publications

• Thymocyte apoptosis induced by p53-dependent and independent pathways

  A. R. Clarke;C. A. Purdie;C. A. Purdie;D. J. Harrison;R. G. Morris

  3060
  Citations

• Crypt stem cells as the cells-of-origin of intestinal cancer

  Nick Barker;Rachel A. Ridgway;Johan H. Van Es;Marc Van De Wetering

  2419
  Citations

• Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

  Peter Mombaerts;Alan R. Clarke;Michael A. Rudnicki;John Iacomini

  1339
  Citations

• Requirement for a functional Rb-1 gene in murine development

  A. R. Clarke;E. R. Maandag;M. Van Roon;N. M. T. Van Der Lugt

  1323
  Citations

• Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.

  Owen J. Sansom;Karen Reed;Anthony Joseph Hayes;Heather Ireland

  944
  Citations

• 129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal.

  J C Manson;A R Clarke;M L Hooper;L Aitchison

  744
  Citations

• Myc deletion rescues Apc deficiency in the small intestine

  Owen J. Sansom;Valerie Meniel;Vanesa Muncan;Toby Phesse

  686
  Citations

• Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells.

  Simon Thompson;Alan R. Clarke;Angela M. Pow;Martin L. Hooper

  630
  Citations

• Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

  Rachel S. Chapman;Paula C. Lourenco;Elizabeth Tonner;David J. Flint

  622
  Citations

• T cell receptor δ gene mutant mice : independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

  Shigeyoshi Itohara;Peter Mombaerts;Juan Lafaille;John Iacomini

  618
  Citations

• High-frequency developmental abnormalities in p53-deficient mice

  Jane F. Armstrong;Matthew H. Kaufman;David J. Harrison;Alan R. Clarke

  594
  Citations

• Reversible Conversion of Monomeric Human Prion Protein Between Native and Fibrilogenic Conformations

  G. S. Jackson;L. L. P. Hosszu;L. L. P. Hosszu;A. Power;A. F. Hill

  467
  Citations

• Hepatic progenitor cells of biliary origin with liver repopulation capacity

  Wei-Yu Lu;Thomas G. Bird;Luke Boulter;Atsunori Tsuchiya

  456
  Citations

• Inducible cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of β-catenin

  Heather Ireland;Richard Kemp;Carol Houghton;Louise Howard

  405
  Citations

• Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice

  Catherine B. Millar;Jacky Guy;Owen J. Sansom;Jim Selfridge

  405
  Citations

• p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation.

  Clarke Ar;Gledhill S;Hooper Ml;Bird Cc

  389
  Citations

• Cystic fibrosis in the mouse by targeted insertional mutagenesis.

  Julia R. Dorin;Paul Dickinson;Eric W. F. W. Alton;Stephen N. Smith

  371
  Citations

• PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology.

  Jean C Manson;A.R. Clarke;P A McBride;I. McConnell

  336
  Citations

• WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis

  Jian-Kan Guo;Aswin Menke;Marie-Claire Gubler;Alan Richard Clarke

  335
  Citations

• The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis

  Teresa Odorisio;Tristan A. Rodriguez;Edward P. Evans;Alan R. Clarke

  309
  Citations