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Medicine

D-Index
89
Citations
36133
World Ranking
12519
National Ranking
1180

Research.com Recognitions

  • 2018 - Member of Academia Europaea
  • 2012 - Fellow of the Royal Society of Edinburgh

Overview

John P. Iredale is affiliated with the University of Bristol in the United Kingdom. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a strong focus on several subfields including Molecular Biology, Pediatrics, Perinatology and Child Health, Obstetrics and Gynecology, Surgery, and Biological Psychiatry.

The scientist's work covers a variety of topics with notable emphasis on gut microbiota and health, Helicobacter pylori-related gastroenterology studies, tryptophan and brain disorders, adolescent and pediatric healthcare, birth, development and health, inflammatory bowel disease, and bipolar disorder and treatment.

Among recent publications, John P. Iredale has contributed to papers such as:

  • Prostaglandin E 2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells, 2021, Science Advances
  • Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis, 2023, Cell Reports
  • Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM), 2021, EBioMedicine
  • In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study, 2024, The Lancet Planetary Health
  • Integration of geoscience frameworks into digital pathology analysis permits quantification of microarchitectural relationships in histological landscapes, 2020, Scientific Reports

Frequent co-authors collaborating with John P. Iredale include Xiaozhong Zheng, Damian J. Mole, Sarah Howie, Siobhan Crittenden, and Marie Goepp.

The scientist's publications appear in several notable venues, with multiple papers published in EBioMedicine, and contributions in Science Advances, Cell Reports, The Lancet Planetary Health, and Scientific Reports.

John P. Iredale has been recognized with the following awards:

  • Member of Academia Europaea, 2018
  • Fellow of the Royal Society of Edinburgh, 2012

Best Publications

  • Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

    Jeremy S. Duffield;Stuart J. Forbes;Christothea M. Constandinou;Spike Clay

  • Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

    J. P. Iredale;R. C. Benyon;J. Pickering;M. Mccullen

  • Liver fibrosis and repair: immune regulation of wound healing in a solid organ

    Antonella Pellicoro;Prakash Ramachandran;John P. Iredale;Jonathan A. Fallowfield

  • Resolving the fibrotic niche of human liver cirrhosis at single cell level

    P Ramachandran;R Dobie;J R Wilson-Kanamori;E F Dora

  • Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ

    John P. Iredale

  • Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

    Prakash Ramachandran;Antonella Pellicoro;Madeleine A. Vernon;Luke Boulter

  • Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

    Neil C Henderson;Thomas D Arnold;Yoshio Katamura;Marilyn M Giacomini

  • Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.

    Luke Boulter;Olivier Govaere;Tom G Bird;Sorina Radulescu

  • Galectin-3 regulates myofibroblast activation and hepatic fibrosis

    Neil C. Henderson;Alison C. Mackinnon;Sarah L. Farnworth;Francoise Poirier

  • Matrix Stiffness Modulates Proliferation, Chemotherapeutic Response and Dormancy in Hepatocellular Carcinoma Cells

    Joerg Schrader;Joerg Schrader;Timothy T. Gordon-Walker;Rebecca L. Aucott;Marielle van Deemter

  • The Bone Marrow Functionally Contributes to Liver Fibrosis

    Francesco P Russo;Malcolm R Alison;Brian W Bigger;Eunice Amofah

  • Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis.

    Neil C. Henderson;Alison C. Mackinnon;Sarah L. Farnworth;Tiina Kipari

  • Now There Are Many (Stages) Where Before There Was One: In Search of a Pathophysiological Classification of Cirrhosis

    Guadalupe Garcia-Tsao;Scott Friedman;John Iredale;Massimo Pinzani

  • Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition. Implications for reversibility of liver fibrosis

    Frank R. Murphy;Razao Issa;Xiaoying Zhou;Shabna Ratnarajah

  • Spontaneous recovery from micronodular cirrhosis: Evidence for incomplete resolution associated with matrix cross-linking

    Razao Issa;Xiaoying Zhou;Christothea M. Constandinou;Jonathan Fallowfield

  • Generation of Functional Human Hepatic Endoderm from Human Induced Pluripotent Stem Cells

    Gareth J. Sullivan;David C. Hay;In Hyun Park;Judy Fletcher

  • Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling

    David C. Hay;Judy Fletcher;Catherine Payne;John D. Terrace

  • Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis

    Jonathan A. Fallowfield;Masashi Mizuno;Timothy J. Kendall;Christothea M. Constandinou

  • Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver

    R. C. Benyon;J. P. Iredale;S. Goddard;P. J. Winwood

  • Pathogenesis of liver fibrosis.

    R. Alcolado;M. J. P. Arthur;J. P. Iredale

Frequent Co-Authors

Stuart J. Forbes
Stuart J. Forbes University of Edinburgh
Derek A. Mann
Derek A. Mann Newcastle University
Philip N. Newsome
Philip N. Newsome University of Birmingham
Mark Bradley
Mark Bradley University of Edinburgh
Owen J. Sansom
Owen J. Sansom University of Glasgow
Bruno Péault
Bruno Péault University of California, Los Angeles
Fiona Oakley
Fiona Oakley Newcastle University
Ian Wilmut
Ian Wilmut University of Edinburgh
Brian R. Walker
Brian R. Walker Newcastle University
Sarah E. M. Howie
Sarah E. M. Howie University of Edinburgh

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