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Overview

Carmine Vacca is a researcher affiliated with the University of Perugia in Italy, specializing in biochemistry, genetics, molecular biology, neuroscience, and medicine. Their work encompasses multiple interrelated scientific fields including molecular biology, biological psychiatry, behavioral neuroscience, neurology, and infectious diseases.

The research topics explored by Carmine Vacca include:

  • Tryptophan and brain disorders
  • Stress responses and cortisol
  • COVID-19 clinical research studies
  • Endoplasmic reticulum stress and disease
  • Sulfur compounds in biology
  • Genomics, phytochemicals, and oxidative stress
  • Circadian rhythm and melatonin

Among recent publications authored or coauthored by Vacca are:

  • "SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione," 2021, published in Redox Biology
  • "Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation," 2020, in Proceedings of the National Academy of Sciences
  • "Endoplasmic reticulum stress and NF-kB activation in SARS-CoV-2 infected cells and their response to antiviral therapy," 2021, in IUBMB Life
  • "Class IA PI3Ks regulate subcellular and functional dynamics of IDO1," 2020, in EMBO Reports
  • "Aspergillus fumigatus tryptophan metabolic route differently affects host immunity," 2021, in Cell Reports

Vacca frequently collaborates with coauthors including Desirée Bartolini, Anna Maria Stabile, Mario Rende, Gabriele Cruciani, and Francesco Galli, each contributing jointly to several publications.

The venues where Vacca's work often appears include:

  • Redox Biology
  • Proceedings of the National Academy of Sciences
  • IUBMB Life
  • EMBO Reports
  • Cell Reports

The body of work reflects a strong focus on biochemical and molecular mechanisms related to immune responses, inflammation, metabolic pathways involving tryptophan, and cellular stress responses, particularly as they pertain to neurological and infectious diseases including COVID-19.

Best Publications

  • Modulation of tryptophan catabolism by regulatory T cells.

    Francesca Fallarino;Ursula Grohmann;Kwang Woo Hwang;Ciriana Orabona

  • CTLA-4-Ig regulates tryptophan catabolism in vivo.

    Ursula Grohmann;Ciriana Orabona;Francesca Fallarino;Carmine Vacca

  • The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells

    Francesca Fallarino;Ursula Grohmann;Sylvaine You;Barbara C. McGrath

  • T cell apoptosis by tryptophan catabolism.

    Francesca Fallarino;Ursula Grohmann;Carmine Vacca;Roberta Bianchi

  • Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

    Maria T Pallotta;Ciriana Orabona;Claudia Volpi;Carmine Vacca

  • Aryl hydrocarbon receptor control of a disease tolerance defence pathway

    Alban Bessede;Alban Bessede;Marco Gargaro;Maria T. Pallotta;Davide Matino

  • IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.

    Teresa Zelante;Antonella De Luca;Pierluigi Bonifazi;Claudia Montagnoli

  • Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

    Luigina Romani;Francesca Fallarino;Antonella De Luca;Claudia Montagnoli

  • CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86

    Ciriana Orabona;Ursula Grohmann;Maria Laura Belladonna;Francesca Fallarino

  • Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy.

    Ursula Grohmann;Claudia Volpi;Francesca Fallarino;Silvia Bozza

  • IL-23 and IL-12 Have Overlapping, but Distinct, Effects on Murine Dendritic Cells

    Maria Laura Belladonna;Jean-Christophe Renauld;Roberta Bianchi;Carmine Vacca

  • A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells.

    Giada Mondanelli;Roberta Bianchi;Maria Teresa Pallotta;Ciriana Orabona

  • Functional expression of indoleamine 2,3-dioxygenase by murine CD8α+ dendritic cells

    Francesca Fallarino;Carmine Vacca;Ciriana Orabona;Maria L. Belladonna

  • Murine Plasmacytoid Dendritic Cells Initiate the Immunosuppressive Pathway of Tryptophan Catabolism in Response to CD200 Receptor Engagement

    Francesca Fallarino;Carine Asselin-Paturel;Carmine Vacca;Roberta Bianchi

  • A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice.

    Ursula Grohmann;Francesca Fallarino;Roberta Bianchi;Ciriana Orabona

  • T Cell Apoptosis by Kynurenines

    Francesca Fallarino;Ursula Grohmann;Carmine Vacca;Ciriana Orabona

  • SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis.

    Ciriana Orabona;Maria Teresa Pallotta;Claudia Volpi;Francesca Fallarino

  • Toward the identification of a tolerogenic signature in IDO-competent dendritic cells.

    Ciriana Orabona;Paolo Puccetti;Paolo Puccetti;Carmine Vacca;Carmine Vacca;Silvio Bicciato;Silvio Bicciato

  • IL-6 Inhibits the Tolerogenic Function of CD8α+ Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

    Ursula Grohmann;Francesca Fallarino;Roberta Bianchi;Maria Laura Belladonna

  • Functional yet Balanced Reactivity to Candida albicans Requires TRIF, MyD88, and IDO-Dependent Inhibition of Rorc

    Antonella De Luca;Claudia Montagnoli;Teresa Zelante;Pierluigi Bonifazi

Frequent Co-Authors

Paolo Puccetti
Paolo Puccetti University of Perugia
Ursula Grohmann
Ursula Grohmann University of Perugia
Francesca Fallarino
Francesca Fallarino University of Perugia
Ciriana Orabona
Ciriana Orabona University of Perugia
Roberta Bianchi
Roberta Bianchi University of Perugia
Maria C. Fioretti
Maria C. Fioretti University of Perugia
Luigina Romani
Luigina Romani University of Perugia
Teresa Zelante
Teresa Zelante University of Perugia
Silvio Bicciato
Silvio Bicciato University of Modena and Reggio Emilia
Louis Boon
Louis Boon University of Amsterdam

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