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Biology and Biochemistry

D-Index
97
Citations
31433
World Ranking
1765
National Ranking
975

Medicine

D-Index
97
Citations
31371
World Ranking
9368
National Ranking
4830

Overview

George C. Prendergast is affiliated with the Lankenau Institute for Medical Research in the United States. Their research spans several interconnected fields with a focus on medicine, biochemistry, genetics, molecular biology, and neuroscience.

The main fields of study in George C. Prendergast's work include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

They have contributed to subfields such as molecular biology, immunology, biological psychiatry, neurology, and gastroenterology.

Their research addresses a variety of scientific topics, with significant emphasis on:

  • Tryptophan and brain disorders
  • Gut microbiota and health
  • Neuroinflammation and neurodegeneration mechanisms
  • Immune cell function and interaction
  • Immune cells in cancer
  • Gastrointestinal motility and disorders
  • Cancer, hypoxia, and metabolism

George C. Prendergast's publication record includes work in prominent venues such as:

  • Cancer Research
  • The Journal of Immunology
  • Frontiers in Immunology
  • Clinical Cancer Research
  • Methods in Cell Biology

Notable recent papers authored or co-authored by George C. Prendergast include:

  • "Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses," 2020, Frontiers in Immunology
  • "Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma," 2020, Clinical Cancer Research
  • "Dietary L-Tryptophan Consumption Determines the Number of Colonic Regulatory T Cells and Susceptibility to Colitis via GPR15," 2023, Nature Communications
  • "The FDA-Approved Anthelmintic Pyrvinium Pamoate Inhibits Pancreatic Cancer Cells in Nutrient-Depleted Conditions by Targeting the Mitochondria," 2021, Molecular Cancer Therapeutics
  • "IDO1 Signaling through GCN2 in a Subpopulation of Gr-1+ Cells Shifts the IFNγ/IL6 Balance to Promote Neovascularization," 2021, Cancer Immunology Research

Frequent co-authors in their research collaborations include:

  • Alexander J. Muller
  • James B. DuHadaway
  • Sunil Thomas
  • Laura Mandik-Nayak
  • Souvik Dey

Best Publications

  • Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.

    Alexander J Muller;James B DuHadaway;P Scott Donover;Erika Sutanto-Ward

  • Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain.

    Adrian R. Ferré-D'Amaré;George C. Prendergast;George C. Prendergast;Edward B. Ziff;Stephen K. Burley;Stephen K. Burley

  • BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

    David E. Jensen;Monja Proctor;Sandra T. Marquis;Heather Perry Gardner

  • Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region.

    George C. Prendergast;Edward B. Ziff

  • Association of Myn, the murine homolog of max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation.

    George C. Prendergast;George C. Prendergast;Deirdre Lawe;Deirdre Lawe;Edward B. Ziff;Edward B. Ziff

  • Aryl hydrocarbon receptor control of a disease tolerance defence pathway

    Alban Bessede;Alban Bessede;Marco Gargaro;Maria T. Pallotta;Davide Matino

  • Inhibition of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Stereoisomers of 1-Methyl-Tryptophan Correlates with Antitumor Responses

    De Yan Hou;Alexander J. Muller;Madhav D. Sharma;James DuHadaway

  • Mechanisms of apoptosis by c-Myc.

    George C Prendergast

  • Classification of current anticancer immunotherapies

    Lorenzo Galluzzi;Erika Vacchelli;José Manuel Bravo-San Pedro;Aitziber Buqué

  • Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan

    Richard Metz;James B. DuHadaway;Uma Kamasani;Lisa Laury-Kleintop

  • Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape.

    Jessica B. Katz;Alexander J. Muller;Alexander J. Muller;George C. Prendergast;George C. Prendergast

  • Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer

    George C. Prendergast;George C. Prendergast;Courtney Smith;Sunil Thomas;Laura Mandik-Nayak

  • Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models.

    N Takahashi;L Duprez;S Grootjans;A Cauwels

  • Discovery of IDO1 Inhibitors: From Bench to Bedside

    George C. Prendergast;William P. Malachowski;James B. DuHadaway;Alexander J. Muller

  • The polyproline region of p53 is required to activate apoptosis but not growth arrest.

    Daitoku Sakamuro;Peter Sabbatini;Eileen White;George C Prendergast

  • BIN1 is a novel MYC-interacting protein with features of a tumour suppressor.

    Daitoku Sakamuro;Katharine J. Elliott;Robert Wechsler-Reya;George C. Prendergast

  • Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.

    P Carmeliet;L Kieckens;L Schoonjans;B Ream

  • c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II.

    Lin-Heng Li;C. Nerlov;G. Prendergast;D. Macgregor

  • Immune escape as a fundamental trait of cancer: focus on IDO.

    G C Prendergast;G C Prendergast

  • IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan

    Richard Metz;Sonja Rust;James B. DuHadaway;Mario R. Mautino

Frequent Co-Authors

Alexander J. Muller
Alexander J. Muller Lankenau Institute for Medical Research
Andrew L. Mellor
Andrew L. Mellor Newcastle University
David H. Munn
David H. Munn Augusta University
Edward B. Ziff
Edward B. Ziff New York University
Jackson B. Gibbs
Jackson B. Gibbs George Washington University
Suzanne Ostrand-Rosenberg
Suzanne Ostrand-Rosenberg University of Maryland, Baltimore County
Charles J. Yeo
Charles J. Yeo Thomas Jefferson University
Jonathan R. Brody
Jonathan R. Brody Thomas Jefferson University
Richard G. Pestell
Richard G. Pestell The Wistar Institute
Eileen White
Eileen White Rutgers, The State University of New Jersey

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