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Molecular Biology

D-Index
70
Citations
15736
World Ranking
1434
National Ranking
729

Overview

Edward V. Prochownik is a researcher affiliated with the University of Pittsburgh in the United States. Their work spans extensive studies in biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology, cancer research, cell biology, biochemistry, and surgery.

Their research covers key themes in several specialized topics, including:

  • Ubiquitin and proteasome pathways
  • Cancer, hypoxia, and metabolism
  • Hippo pathway signaling and YAP/TAZ
  • Cancer, lipids, and metabolism
  • Mitochondrial function and pathology
  • Lipid metabolism and biosynthesis
  • RNA research and splicing

Edward V. Prochownik has published numerous papers in a variety of venues. Frequent publication platforms include bioRxiv (Cold Spring Harbor Laboratory), Cells, Cell Reports, Advanced Science, and Hepatology.

Selected recent papers authored or co-authored by Prochownik include:

  • The IKKβ-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis, 2020, Hepatology
  • The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells, 2021, Cells
  • P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis, 2022, Hepatology
  • Normal and Neoplastic Growth Suppression by the Extended Myc Network, 2022, Cells
  • Ceramide-mediated gut dysbiosis enhances cholesterol esterification and promotes colorectal tumorigenesis in mice, 2021, JCI Insight

They collaborate frequently with a group of co-authors including Huabo Wang, Jie Lu, Sarangarajan Ranganathan, Xinyi Zhou, and Youjun Li.

Best Publications

  • MYC oncogenes and human neoplastic disease

    Chadd E Nesbit;Jean M Tersak;Edward V Prochownik;Edward V Prochownik

  • Myc-induced T cell leukemia in transgenic zebrafish.

    David M. Langenau;David Traver;Adolfo A. Ferrando;Jeffery L. Kutok

  • Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin.

    V M Dixit;S Green;V Sarma;L B Holzman

  • Low molecular weight inhibitors of Myc-Max interaction and function.

    Xiaoying Yin;Christine Giap;John S Lazo;Edward V Prochownik;Edward V Prochownik

  • Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation.

    M F Clarke;J F Kukowska-Latallo;E Westin;M Smith

  • Deregulated expression of c-myc by murine erythroleukaemia cells prevents differentiation.

    E. V. Prochownik;J. Kukowska

  • c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle

    James J. Ryan;Edward Prochownik;Christopher A. Gottlieb;Ingrid J. Apel

  • Differential Interactions of Id Proteins with Basic-Helix-Loop-Helix Transcription Factors

    Kenneth Langlands;Xiaoying Yin;Geetha Anand;Edward V. Prochownik;Edward V. Prochownik

  • Mutation of the MXI1 gene in prostate cancer

    Linette R. Eagle;Xiaoying Yin;Arthur R. Brothman;Briana J. Williams

  • Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1.

    Rachel A Egler;Elaine Fernandes;Kristi Rothermund;Susan Sereika

  • c-myc antisense transcripts accelerate differentiation and inhibit G1 progression in murine erythroleukemia cells.

    E V Prochownik;J Kukowska;C Rodgers

  • Improved low molecular weight myc-max inhibitors

    Steven J. Metallo;Edward V. Prochownik

  • Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

    Dalia I Hammoudeh;Ariele Viacava Follis;Edward V Prochownik;Steven J Metallo

  • C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells

    D. Zhuang;S. Mannava;S. Mannava;V. Grachtchouk;V. Grachtchouk;W. H. Tang

  • The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues.

    Eric S. Goetzman;Edward V. Prochownik

  • Regulation of megakaryocyte phenotype in human erythroleukemia cells.

    M W Long;C H Heffner;J L Williams;C Peters

  • Therapeutic Targeting of Myc

    Edward V. Prochownik;Peter K. Vogt

  • c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle.

    H Wang;S Mannava;V Grachtchouk;D Zhuang

  • Structural rationale for the coupled binding and unfolding of the c-Myc oncoprotein by small molecules.

    Ariele Viacava Follis;Dalia I. Hammoudeh;Huabo Wang;Edward V. Prochownik;Edward V. Prochownik

  • C-myc overexpression and p53 loss cooperate to promote genomic instability.

    Xiao Ying Yin;Linnette Grove;Nabanita S. Datta;Michael W. Long

Frequent Co-Authors

John S. Lazo
John S. Lazo University of Virginia
Jerry Vockley
Jerry Vockley University of Pittsburgh
Dipanjan Pan
Dipanjan Pan Pennsylvania State University
Stuart H. Orkin
Stuart H. Orkin Harvard University
A. Thomas Look
A. Thomas Look Harvard University
Bennett Van Houten
Bennett Van Houten University of Pittsburgh
Robert D. Nicholls
Robert D. Nicholls University of Pittsburgh
Joseph R. Testa
Joseph R. Testa Fox Chase Cancer Center
Satdarshan P. Monga
Satdarshan P. Monga University of Pittsburgh

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