World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
91
Citations
33195
World Ranking
2306
National Ranking
1232

Overview

Bruno Calabretta is affiliated with Thomas Jefferson University in the United States. Their research focuses primarily on medicine and biochemistry, genetics, and molecular biology, with specific attention to subfields such as molecular biology, hematology, pulmonary and respiratory medicine, oncology, and pathology and forensic medicine.

The scientist has contributed extensively to topics including advanced breast cancer therapies, acute myeloid leukemia research, protein degradation and inhibitors, lung cancer research studies, chromatin remodeling and cancer, cancer mechanisms and therapy, and genomics and chromatin dynamics.

Frequent collaborators in their research include Patrizia Porazzi, Marco De Dominici, Alexander Mazo, Luca Pagliaroli, and Sandra Deliard. Their publications have appeared in several prominent venues, notably Blood, Blood Cancer Discovery, Cancer Research, Nature Communications, and Genes.

  • Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs (2020, Blood)
  • Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders (2021, Nature Communications)
  • Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on MIR300 Antiproliferative and PP2A-Activating Functions (2020, Blood Cancer Discovery)
  • Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression (2021, Cancer Research)
  • Targeting the CDK6 Dependence of Ph+ Acute Lymphoblastic Leukemia (2021, Genes)

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

    Tomasz Skorski;Alfonso Bellacosa;Margaret Nieborowska‐Skorska;Miroslaw Majewski

  • THE BIOLOGY OF CML BLAST CRISIS

    Bruno Calabretta;Danilo Perrotti

  • Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells.

    Cristian Bellodi;Maria Rosa Lidonnici;Ashley Hamilton;G. Vignir Helgason

  • Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis.

    Francesca Peruzzi;Marco Prisco;Michael Dews;Paolo Salomoni

  • Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

    Tomasz Skorski;Palanisamy Kanakaraj;Margaret Nieborowska-Skorska;Mariusz Z. Ratajczak

  • A c-myb antisense oligodeoxynucleotide inhibits normal human hematopoiesis in vitro

    Alan M. Gewirtz;Bruno Calabretta

  • Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin

    D Jaskulski;Jk deRiel;We Mercer;Bruno Calabretta

  • Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides

    Cezary Szczylik;Tomasz Skorski;Nicholas C. Nicolaides;Livia Manzella

  • An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines.

    Giovanni Anfossi;Alan M. Gewirtz;Bruno Calabretta

  • Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis

    Malgorzata Nieborowska-Skorska;Mariusz A. Wasik;Artur Slupianek;Paolo Salomoni

  • BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2.

    Danilo Perrotti;Vincenzo Cesi;Rossana Trotta;Clara Guerzoni

  • Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein.

    B Calabretta;R Battini;L Kaczmarek;J K de Riel

  • Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: an in vitro study relevant to bone marrow purging.

    Bruno Calabretta;Robert B. Sims;Mauro Valtieri;Daniele Caracciolo

  • Regulation of the proliferating cell nuclear antigen cyclin and thymidine kinase mRNA levels by growth factors.

    D Jaskulski;C Gatti;S Travali;Bruno Calabretta

  • p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107.

    Pp Claudio;Cm Howard;A Baldi;A De Luca

  • G1/S transition in normal human T-lymphocytes requires the nuclear protein encoded by c-myb.

    Alan M. Gewirtz;Giovanni Anfossi;Donatella Venturelli;Susanna Valpreda

  • De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells

    Manoranjan Santra;Tomasz Skorski;Bruno Calabretta;Edmund C. Lattime

  • Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases.

    Manoranjan Santra;David M. Mann;Edward W. Mercer;Thomas Skorski

  • Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells (vol 119, pg 1109, 2009)

    C Bellodi;Lidonnici;A Hamilton;GV Helgason

Frequent Co-Authors

Paolo Salomoni
Paolo Salomoni German Center for Neurodegenerative Diseases
Alan M. Gewirtz
Alan M. Gewirtz University of Pennsylvania
renato baserga
renato baserga Temple University
Leszek Kaczmarek
Leszek Kaczmarek Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
Sergio Ferrari
Sergio Ferrari University of Modena and Reggio Emilia
Renato V. Iozzo
Renato V. Iozzo Thomas Jefferson University
Tomasz Skorski
Tomasz Skorski Temple University
Mariusz A. Wasik
Mariusz A. Wasik University of Pennsylvania
Gerald Zon
Gerald Zon TriLink BioTechnologies (United States)
Tessa L. Holyoake
Tessa L. Holyoake University of Glasgow

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