James D. Griffin

Overview

Best Publications

• Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.

  Ross L. Levine;Ross L. Levine;Martha Wadleigh;Jan Cools;Benjamin L. Ebert;Benjamin L. Ebert

  3760
  Citations

• A Tyrosine Kinase Created by Fusion of the PDGFRA and FIP1L1 Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome

  Jan Cools;Jan Cools;Daniel J. DeAngelo;Jason Gotlib;Elizabeth H. Stover

  2166
  Citations

• The roles of FLT3 in hematopoiesis and leukemia.

  D. Gary Gilliland;James D. Griffin

  1954
  Citations

• Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl

  Ellen Weisberg;Paul W. Manley;Werner Breitenstein;Josef Brüggen

  1879
  Citations

• Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL.

  Hagop M Kantarjian;Francis Giles;Lydia Wunderle;Kapil Bhalla

  1678
  Citations

• Granulocyte colony-stimulating factor and its receptor.

  GD Demetri;JD Griffin

  1333
  Citations

• The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element.

  James A. DeCaprio;John W. Ludlow;Dennis Lynch;Yusuke Furukawa

  1179
  Citations

• STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications

  David A. Tuveson;Nicholas A. Willis;Tyler Jacks;Tyler Jacks;James D. Griffin

  892
  Citations

• Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Chemotherapy-Induced Myelosuppression

  Karen S. Antman;James D. Griffin;Anthony Elias;Mark A. Socinski

  841
  Citations

• Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412

  Richard M. Stone;Daniel J. DeAngelo;Virginia Klimek;Ilene Galinsky

  840
  Citations

• Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia

  Ellen Weisberg;Paul W. Manley;Sandra W. Cowan-Jacob;Andreas Hochhaus

  810
  Citations

• Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion.

  P J Simpson;R F Todd rd;J C Fantone;J K Mickelson

  800
  Citations

• Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.

  Ellen Weisberg;Christina Boulton;Louise M Kelly;Paul Manley

  732
  Citations

• GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR EXPANDS THE CIRCULATING HAEMOPOIETIC PROGENITOR CELL COMPARTMENT IN MAN

  MarkA. Socinski;Anthony Elias;Lowell Schnipper;StephenA. Cannistra

  721
  Citations

• MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.

  Lizi Wu;Jon C. Aster;Stephen C. Blacklow;Robert Lake

  719
  Citations

• Expression of myeloid differentiation antigens on normal and malignant myeloid cells.

  James D. Griffin;Jerome Ritz;Lee M. Nadler;Stuart F. Schlossman

  637
  Citations

• t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway

  Giovanni Tonon;Sanjay Modi;Lizi Wu;Akihito Kubo

  618
  Citations

• Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.

  Nadia Carlesso;David A. Frank;James D. Griffin

  601
  Citations

• JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.

  F W Quelle;N Sato;B A Witthuhn;R C Inhorn

  595
  Citations

• c-MET Mutational Analysis in Small Cell Lung Cancer Novel Juxtamembrane Domain Mutations Regulating Cytoskeletal Functions

  Patrick Chi-Chung Ma;Takashi Kijima;Gautam Maulik;Edward A. Fox

  579
  Citations