Alan M. Gewirtz

Overview

Best Publications

• Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

  W.-J. Song;M. G. Sullivan;R. D. Legare;S. Hutchings

  1255
  Citations

• Nucleic-acid therapeutics: basic principles and recent applications.

  Joanna B. Opalinska;Alan M. Gewirtz

  978
  Citations

• Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner.

  Marcin Majka;Marcin Majka;Anna Janowska-Wieczorek;Anna Janowska-Wieczorek;Janina Ratajczak;Janina Ratajczak;Karen Ehrenman;Karen Ehrenman

  753
  Citations

• Real time detection of DNA.RNA hybridization in living cells.

  Deborah L. Sokol;Xiaolin Zhang;Ponzy Lu;Alan M. Gewirtz

  648
  Citations

• Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

  Tomasz Skorski;Palanisamy Kanakaraj;Margaret Nieborowska-Skorska;Mariusz Z. Ratajczak

  601
  Citations

• A c-myb antisense oligodeoxynucleotide inhibits normal human hematopoiesis in vitro

  Alan M. Gewirtz;Bruno Calabretta

  582
  Citations

• Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides

  Cezary Szczylik;Tomasz Skorski;Nicholas C. Nicolaides;Livia Manzella

  515
  Citations

• An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines.

  Giovanni Anfossi;Alan M. Gewirtz;Bruno Calabretta

  437
  Citations

• FACILITATING OLIGONUCLEOTIDE DELIVERY : HELPING ANTISENSE DELIVER ON ITS PROMISE

  Alan M. Gewirtz;Cy A. Stein;Peter M. Glazer

  430
  Citations

• Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides.

  C Beltinger;H U Saragovi;R M Smith;L LeSauteur

  386
  Citations

• The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL) - the translocation defining a new T-ALL subtype in very young children

  Emmanuelle Clappier;Wendy Cuccuini;Anna Kalota;Antoine Crinquette

  377
  Citations

• Nucleic Acid Therapeutics: State of the Art and Future Prospects

  Alan M. Gewirtz;Deborah L. Sokol;Mariusz Z. Ratajczak

  376
  Citations

• In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides

  Mariusz Z. Ratajczak;Jeffrey A. Kant;Selina M. Luger;Nobuko Hijiya

  335
  Citations

• Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: an in vitro study relevant to bone marrow purging.

  Bruno Calabretta;Robert B. Sims;Mauro Valtieri;Daniele Caracciolo

  315
  Citations

• Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells

  Andrzej Ptasznik;Yuji Nakata;Anna Kalota;Stephen G Emerson

  298
  Citations

• Embryonic and adult stem cell therapy

  Carl T. Henningson;Marisha A. Stanislaus;Alan M. Gewirtz

  261
  Citations

• Inhibition of human megakaryocytopoiesis in vitro by platelet factor 4 (PF4) and a synthetic COOH-terminal PF4 peptide.

  A M Gewirtz;B Calabretta;B Rucinski;S Niewiarowski

  206
  Citations

• Megakaryocyte precursors, megakaryocytes and platelets express the HIV co-receptor CXCR4 on their surface: determination of response to stromal-derived factor-1 by megakaryocytes and platelets.

  M A Kowalska;J Ratajczak;J Hoxie;L F Brass

  191
  Citations

• Post-transcriptional gene silencing by RNAi in mammalian cells

  Alan Gewirtz

  187
  Citations

• Role of the KIT protooncogene in normal and malignant human hematopoiesis.

  Mz Ratajczak;Sm Luger;K DeRiel;J Abrahm

  179
  Citations