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David M. Langenau

David M. Langenau

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
11909
World Ranking
15528
National Ranking
6478

Overview

David M. Langenau is affiliated with Harvard University in the United States. Their research broadly encompasses biochemistry, genetics, and molecular biology, with 51 publications in this main field. Medicine constitutes another significant area, with 40 publications contributed.

Their subfields of study include molecular biology, pulmonary and respiratory medicine, cell biology, immunology, and oncology. The scientific topics frequently addressed in their work cover sarcoma diagnosis and treatment, zebrafish biomedical research applications, single-cell and spatial transcriptomics, CAR-T cell therapy research, immune cell function and interaction, tumors and oncological cases, and acute lymphoblastic leukemia research.

Recent scholarly contributions by David M. Langenau include the following papers:

  • Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials, 2021, Nature Reviews Drug Discovery
  • Zebrafish patient avatars in cancer biology and precision cancer therapy, 2020, Nature reviews. Cancer
  • The macrophage-expressed gene ( mpeg ) 1 identifies a subpopulation of B cells in the adult zebrafish, 2020, Journal of Leukocyte Biology
  • Single-cell analysis and functional characterization uncover the stem cell hierarchies and developmental origins of rhabdomyosarcoma, 2022, Nature Cancer
  • Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia, 2022, Blood

David M. Langenau has collaborated frequently with several researchers, including:

  • Chuan Yan (19 collaborations)
  • Yun Wei (15 collaborations)
  • Qiqi Yang (13 collaborations)
  • Qian Qin (10 collaborations)
  • Daniel Do (9 collaborations)

The scientist has a publication record in various academic venues, notably:

  • Cancer Research (11 publications)
  • Leukemia (3 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)
  • Cryobiology (3 publications)
  • Zenodo (CERN European Organization for Nuclear Research) (3 publications)

Best Publications

  • Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)

    Jeffry D. Sander;Elizabeth J. Dahlborg;Mathew J. Goodwin;Lindsay Cade

  • The use of zebrafish to understand immunity

    Nikolaus S Trede;David M Langenau;David Traver;A.Thomas Look

  • Myc-induced T cell leukemia in transgenic zebrafish.

    David M. Langenau;David Traver;Adolfo A. Ferrando;Jeffery L. Kutok

  • Myelopoiesis in the zebrafish, Danio rerio

    Carolyn M. Bennett;Carolyn M. Bennett;Carolyn M. Bennett;John P. Kanki;John P. Kanki;John P. Kanki;Jennifer Rhodes;Jennifer Rhodes;Jennifer Rhodes;Ting X. Liu;Ting X. Liu;Ting X. Liu

  • Clusters of circulating tumor cells traverse capillary-sized vessels

    Sam H. Au;Brian D. Storey;John C. Moore;Qin Tang

  • In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.

    David M. Langenau;Adolfo A. Ferrando;David Traver;Jeffery L. Kutok

  • Effects of RAS on the genesis of embryonal rhabdomyosarcoma.

    David M. Langenau;Matthew D. Keefe;Narie Y. Storer;Jeffrey R. Guyon

  • Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials.

    E. Elizabeth Patton;Leonard I. Zon;David M. Langenau

  • Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM

    Huidong Chen;Luca Albergante;Luca Albergante;Jonathan Y. Hsu;Jonathan Y. Hsu;Caleb A. Lareau;Caleb A. Lareau

  • Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia

    David M. Langenau;Hui Feng;Stephane Berghmans;John P. Kanki

  • Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation

    David Traver;Alissa Winzeler;Howard M. Stern;Elizabeth A. Mayhall

  • Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish.

    Chuan Yan;Dalton C. Brunson;Qin Tang;Daniel Do

  • The zebrafish: a new model of T-cell and thymic development

    David M. Langenau;Leonard I. Zon

  • Making waves in cancer research: new models in the zebrafish

    Stephane Berghmans;Cicely Jette;David Langenau;Karl Hsu

  • Zebrafish patient avatars in cancer biology and precision cancer therapy.

    Maurizio Fazio;Julien Ablain;Julien Ablain;Yan Chuan;David M Langenau

  • Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs).

    Finola E. Moore;Deepak Reyon;Jeffry D. Sander;Sarah A. Martinez

  • Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish.

    Xiuning Le;David M. Langenau;David M. Langenau;Matthew D. Keefe;Matthew D. Keefe;Jeffery L. Kutok

  • Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing.

    Qin Tang;Sowmya Iyer;Riadh Lobbardi;John C. Moore

  • T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation

    Hui Feng;David L. Stachura;Richard White;Alejandro Gutierrez;Alejandro Gutierrez

  • Multiparameter analysis of murine bone marrow side population cells

    Daniel J. Pearce;Christopher M. Ridler;Catherine Simpson;Dominique Bonnet

Frequent Co-Authors

Leonard I. Zon
Leonard I. Zon Harvard University
A. Thomas Look
A. Thomas Look Harvard University
Jeffery L. Kutok
Jeffery L. Kutok Epizyme (United States)
Ruslan I. Sadreyev
Ruslan I. Sadreyev Harvard University
Donna Neuberg
Donna Neuberg Harvard University
Franki Speleman
Franki Speleman Ghent University
Graham Dellaire
Graham Dellaire Dalhousie University
Javed Khan
Javed Khan National Institutes of Health
Yi Zhou
Yi Zhou Harvard University
Raul Mostoslavsky
Raul Mostoslavsky Harvard University

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