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Biology and Biochemistry

D-Index
49
Citations
11562
World Ranking
17905
National Ranking
7328

Overview

Carol C. Gregorio is affiliated with the University of Arizona in the United States. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology, with particular concentration in cardiology and cardiovascular medicine, molecular biology, and cell biology. Their work spans several interrelated areas concerning muscle physiology, cardiomyopathy, and cellular mechanics.

Gregorio's publications explore detailed aspects of muscle structure, function, and cardiovascular biology, often investigating the mechanics of actin filaments and myofibrillogenesis in muscle tissue. Key recent papers include:

  • Nebulin and Lmod2 are critical for specifying thin-filament length in skeletal muscle, 2020, Science Advances
  • Leiomodin creates a leaky cap at the pointed end of actin-thin filaments, 2020, PLoS Biology
  • CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle, 2021, Communications Biology
  • The role of leiomodin in actin dynamics: a new road or a secret gate, 2021, FEBS Journal
  • Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells, 2021, Stem Cell Reports

Their research covers several main topics, such as cardiomyopathy and myosin studies, muscle physiology and disorders, cardiovascular effects of exercise, cellular mechanics and interactions, congenital heart defects research, genetic neurodegenerative diseases, and neurogenetic and muscular disorders research.

Frequent collaborators include Alla S. Kostyukova, Garry E. Smith, Jessika Iwanski, Mert Colpan, and Rachel M. Mayfield. Their work has been published most often in venues like Biophysical Journal, Science Advances, Communications Biology, PLoS Biology, and FEBS Journal.

The concentration of Gregorio's studies on cardiology and muscle-related molecular biology reflects a strong emphasis on understanding muscle function at both cellular and molecular levels. This multidisciplinary approach integrates genetics, cell biology, and molecular mechanisms to investigate cardiovascular health and muscle disorders.

Best Publications

  • The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy

    Ralph Knöll;Masahiko Hoshijima;Hal M. Hoffman;Veronika Person

  • The Complete Gene Sequence of Titin, Expression of an Unusual ≈700-kDa Titin Isoform, and Its Interaction With Obscurin Identify a Novel Z-Line to I-Band Linking System

    Marie Louise Bang;Thomas Centner;Friderike Fornoff;Adam J. Geach

  • Striated muscle cytoarchitecture: an intricate web of form and function.

    Kathleen A. Clark;Abigail S. McElhinny;Mary C. Beckerle;Carol C. Gregorio

  • Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.

    Thomas Centner;Junko Yano;Eiichi Kimura;Abigail S. McElhinny

  • Series of Exon-Skipping Events in the Elastic Spring Region of Titin as the Structural Basis for Myofibrillar Elastic Diversity

    Alexandra Freiburg;Karoly Trombitas;Wolfgang Hell;Olivier Cazorla

  • Muscle assembly: a titanic achievement?

    Carol C Gregorio;Henk Granzier;Hiroyuki Sorimachi;Siegfried Labeit

  • The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.

    Melanie K. Miller;Marie Louise Bang;Christian C. Witt;Dietmar Labeit

  • The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity.

    Carol C. Gregorio;Karoly Trombitás;Thomas Centner;Bernhard Kolmerer

  • Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.

    Abigail S. McElhinny;Kazumi Kakinuma;Hiroyuki Sorimachi;Siegfried Labeit

  • Myopalladin, a Novel 145-Kilodalton Sarcomeric Protein with Multiple Roles in Z-Disc and I-Band Protein Assemblies

    Marie Louise Bang;Ryan E. Mudry;Abigail S. McElhinny;Karoly Trombitás

  • I-band titin in cardiac muscle is a three-element molecular spring and is critical for maintaining thin filament structure

    Wolfgang A. Linke;Diane E. Rudy;Thomas Centner;Mathias Gautel

  • Tissue-specific expression and alpha-actinin binding properties of the Z-disc titin: implications for the nature of vertebrate Z-discs

    H. Sorimachi;A. Freiburg;Bernhard Kolmerer;S. Ishiura

  • Overview of the Muscle Cytoskeleton.

    Christine A. Henderson;Christopher G. Gomez;Stefanie M. Novak;Lei Mi-Mi

  • To the heart of myofibril assembly.

    Carol C. Gregorio;Parker B. Antin

  • Requirement of pointed-end capping by tropomodulin to maintain actin filament length in embryonic chick cardiac myocytes

    Carol C. Gregorio;Annemarie Weber;Meredith Bondad;Cynthia R. Pennise

  • Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy

    Michaela Yuen;Sarah A. Sandaradura;James J. Dowling;James J. Dowling;Alla S. Kostyukova

  • Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization

    Laura T. Donlin;Christian Andresen;Steffen Just;Eugene Rudensky

  • Specific interaction of the potassium channel β-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system

    Tetsushi Furukawa;Yasuko Ono;Hiroyuki Tsuchiya;Yoshifumi Katayama

  • The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments.

    Abigail S. McElhinny;Bernhard Kolmerer;Velia M. Fowler;Siegfried Labeit

  • Mechanisms of thin filament assembly in embryonic chick cardiac myocytes: tropomodulin requires tropomyosin for assembly.

    Carol C. Gregorio;Velia M. Fowler

Frequent Co-Authors

Henk Granzier
Henk Granzier University of Arizona
Siegfried Labeit
Siegfried Labeit European Bioinformatics Institute
Velia M. Fowler
Velia M. Fowler University of Delaware
Hiroyuki Sorimachi
Hiroyuki Sorimachi Tokyo Metropolitan Institute of Medical Science
Paul A. Krieg
Paul A. Krieg University of Arizona
Alan H. Beggs
Alan H. Beggs Harvard Medical School
Michael Gotthardt
Michael Gotthardt University of Bonn
Wolfgang A. Linke
Wolfgang A. Linke University of Münster
Christine E. Seidman
Christine E. Seidman Harvard University
Benoit G. Bruneau
Benoit G. Bruneau Gladstone Institutes

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