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Biology and Biochemistry

D-Index
75
Citations
21447
World Ranking
5286
National Ranking
41

Overview

Olli Carpén is affiliated with the University of Helsinki in Finland. Their research primarily focuses on Medicine and Biochemistry, Genetics and Molecular Biology, with a substantial number of publications in these fields. The scientist's work spans several subfields including Molecular Biology, Cancer Research, Oncology, Genetics, and Reproductive Medicine.

Carpén's research topics cover a variety of themes related to cancer and genetics. These include:

  • Cancer Genomics and Diagnostics
  • Ovarian cancer diagnosis and treatment
  • Single-cell and spatial transcriptomics
  • Cancer-related molecular mechanisms research
  • Cancer Cells and Metastasis
  • RNA modifications and cancer
  • Genetic Associations and Epidemiology

Notable recent publications by Carpén include:

  • FinnGen provides genetic insights from a well-phenotyped isolated population, 2023, Nature
  • FinnGen: Unique genetic insights from combining isolated population and national health register data, 2022, bioRxiv (Cold Spring Harbor Laboratory)
  • Neuropathologic features of four autopsied COVID-19 patients, 2020, Brain Pathology
  • Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer, 2022, Science Advances
  • Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance, 2021, Nature Communications

Carpén collaborates frequently with several researchers, including Johanna Hynninen, Kaisa Huhtinen, Sampsa Hautaniemi, Sakari Hietanen, and Anders Mälarstig. These coauthors have contributed to multiple publications together, indicating ongoing collaboration.

The scientist's work has been published repeatedly in a number of venues, with the most frequent being:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Clinical Cancer Research
  • Bioinformatics
  • Scientific Reports

Best Publications

  • α‐actinin revisited: A fresh look at an old player

    Carol A. Otey;Olli Carpen

  • Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate.

    Leena Heiska;Kaija Alfthan;Mikaela Grönholm;Pekka Vilja

  • Myotilin is mutated in limb girdle muscular dystrophy 1A

    Michael A. Hauser;Stephen K. Horrigan;Paula Salmikangas;Udana M. Torian

  • Regulation of monocyte migration by amphoterin (HMGB1).

    Ari Rouhiainen;Juha Kuja-Panula;Erika Wilkman;Jukka Pakkanen

  • Expression of vascular endothelial growth factor receptors 1, 2 and 3 in placentas from normal and complicated pregnancies

    Satu Helske;Piia Vuorela;Olli Carpén;Carsten Hornig

  • Myotilin, a Novel Sarcomeric Protein with Two Ig-like Domains, is Encoded by a Candidate Gene for Limb-Girdle Muscular Dystrophy

    Paula Salmikangas;Olli-Matti Mykkänen;Mikaela Grönholm;Leena Heiska

  • ICAM-2 redistributed by ezrin as a target for killer cells.

    Tuula S. Helander;Olli Carpén;Ossi Turunen;Panu E. Kovanen

  • Evolution of Cerebral Tumor Necrosis Factor-α Production During Human Ischemic Stroke

    Tiina Sairanen;Olli Carpén;Marja-Liisa Karjalainen-Lindsberg;Anders Paetau

  • The ezrin protein family: membrane-cytoskeleton interactions and disease associations.

    Antti Vaheri;Olli Carpén;Leena Heiska;Tuula S Helander

  • Indications for a Novel Muscular Dystrophy Pathway: γ-Filamin, the Muscle-Specific Filamin Isoform, Interacts with Myotilin

    Peter F.M. van der Ven;Sebastian Wiesner;Paula Salmikangas;Daniel Auerbach

  • Biosynthesis and Intracellular Targeting of the CLN3 Protein Defective in Batten Disease

    Irma Järvelä;Markku Sainio;Terhi Rantamäki;Vesa M. Olkkonen

  • Myotilin, the limb-girdle muscular dystrophy 1A (LGMD1A) protein, cross-links actin filaments and controls sarcomere assembly

    Paula Salmikangas;Peter F.M. van der Ven;Maciej Lalowski;Anu Taivainen

  • Complement activation in the central nervous system following blood-brain barrier damage in man.

    P J Lindsberg;J Ohman;T Lehto;M L Karjalainen-Lindsberg

  • Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton

    M. Sainio;F. Zhao;L. Heiska;O. Turunen

  • Characterization of human palladin, a microfilament-associated protein.

    Olli-Matti Mykkänen;Mikaela Grönholm;Mikko Rönty;Maciej Lalowski

  • Ultrastructure of human natural killer cells: nature of the cytolytic contacts in relation to cellular secretion.

    O Carpen;I Virtanen;E Saksela

  • VEGF, ITS RECEPTORS AND THE TIE RECEPTORS IN RECURRENT MISCARRIAGE

    Piia Vuorela;Olli Carpén;Maija Tulppala;Erja Halmesmäki

  • Inhibition of T Cell Activation by Cyclic Adenosine 5′-Monophosphate Requires Lipid Raft Targeting of Protein Kinase A Type I by the A-Kinase Anchoring Protein Ezrin

    Anja Ruppelt;Randi Mosenden;Mikaela Grönholm;Einar M. Aandahl

  • Neuropathologic features of four autopsied COVID-19 patients.

    Jonas Kantonen;Shamita Mahzabin;Mikko I. Mäyränpää;Olli Tynninen

  • Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization.

    Kaija Alfthan;Leena Heiska;Mikaela Grönholm;G. Herma Renkema

Frequent Co-Authors

Sampsa Hautaniemi
Sampsa Hautaniemi University of Helsinki
Antti Vaheri
Antti Vaheri University of Helsinki
Caj Haglund
Caj Haglund University of Helsinki
Carl G. Gahmberg
Carl G. Gahmberg University of Helsinki
Kim Pettersson
Kim Pettersson University of Turku
Matti Poutanen
Matti Poutanen University of Turku
Carol A. Otey
Carol A. Otey University of North Carolina at Chapel Hill
Juha Kere
Juha Kere Karolinska Institute
Tero Aittokallio
Tero Aittokallio University of Helsinki
Fredrik Pontén
Fredrik Pontén Uppsala University

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