D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 43 Citations 8,446 113 World Ranking 14384 National Ranking 1022

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

His scientific interests lie mostly in Biochemistry, Cell biology, Protein structure, Ezrin and FERM domain. Toshio Hakoshima frequently studies issues relating to Crystal structure and Biochemistry. In his study, which falls under the umbrella issue of Cell biology, HMG-box, DNA-binding domain and Transcription factor is strongly linked to Binding site.

His studies in Protein structure integrate themes in fields like Genetics, Alpha helix, Biophysics, Peptide sequence and Stereochemistry. When carried out as part of a general Ezrin research project, his work on Moesin and Radixin is frequently linked to work in Phosphotyrosine-binding domain and Peptide binding, therefore connecting diverse disciplines of study. His research integrates issues of Sequence motif, Beta sheet, Pleckstrin homology domain and Immunoglobulin superfamily in his study of FERM domain.

His most cited work include:

  • Gibberellin-induced DELLA recognition by the gibberellin receptor GID1 (434 citations)
  • Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. (330 citations)
  • Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs (239 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Biochemistry, Crystallography, Crystal structure, Biophysics and Stereochemistry. His Biophysics study combines topics from a wide range of disciplines, such as Moesin, Ezrin, Radixin and FERM domain. His work in Radixin tackles topics such as Cell adhesion molecule which are related to areas like Beta sheet.

His FERM domain study combines topics in areas such as Cytoplasm, Cell biology and Signal transducing adaptor protein. He has included themes like Nucleotide, Guanine, Polyamine, Hydrogen bond and Ribonuclease T1 in his Stereochemistry study. His Protein structure research incorporates elements of Genetics, Binding site and Rho-associated protein kinase.

He most often published in these fields:

  • Biochemistry (41.82%)
  • Crystallography (32.27%)
  • Crystal structure (22.73%)

What were the highlights of his more recent work (between 2012-2021)?

  • Biochemistry (41.82%)
  • Cell biology (17.27%)
  • Biophysics (28.18%)

In recent papers he was focusing on the following fields of study:

Biochemistry, Cell biology, Biophysics, Stereochemistry and Plasma protein binding are his primary areas of study. His study connects Polyhydroxyalkanoates and Biochemistry. His Cell biology research includes themes of Receptor, Karrikin and Strigolactone.

His study in Biophysics is interdisciplinary in nature, drawing from both Cell migration, Haptotaxis and Helix. His Stereochemistry research incorporates themes from Crystallography, Catalytic triad, Active site, Cupriavidus necator and Protein structure. Toshio Hakoshima interconnects Moesin, Ezrin, Radixin and Cullin in the investigation of issues within FERM domain.

Between 2012 and 2021, his most popular works were:

  • Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs (239 citations)
  • Structures of D14 and D14L in the strigolactone and karrikin signaling pathways (166 citations)
  • Strigolactone perception and deactivation by a hydrolase receptor DWARF14 (76 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

His main research concerns Plasma protein binding, Biochemistry, Stereochemistry, Biophysics and Hydrolase. His research in Plasma protein binding intersects with topics in Protein domain, Auxin, Phosphorylation and Helix. The study incorporates disciplines such as Protein structure, Catalytic triad and Cupriavidus necator, Polyhydroxyalkanoates in addition to Stereochemistry.

His biological study spans a wide range of topics, including Stereoisomerism, Cereblon, Glutarimide, Enantiomer and Binding site. His Biophysics research integrates issues from Cytoplasm and Gravitropism, Polar auxin transport, Arabidopsis. His research investigates the link between Enzyme and topics such as Cell biology that cross with problems in Zinc finger.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Gibberellin-induced DELLA recognition by the gibberellin receptor GID1

Kohji Murase;Yoshinori Hirano;Tai-ping Sun;Toshio Hakoshima.
Nature (2008)

587 Citations

Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain.

Keisuke Hamada;Toshiyuki Shimizu;Takeshi Matsui;Shoichiro Tsukita.
The EMBO Journal (2000)

437 Citations

Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product

Shoko Hirotsu;Yasuko Abe;Kengo Okada;Noriyuki Nagahara.
Proceedings of the National Academy of Sciences of the United States of America (1999)

324 Citations

The Molecular Structure of a DNA-Triostin A Complex

A. H.-J. Wang;G. Ughetto;G. J. Quigley;T. Hakoshima.
Science (1984)

316 Citations

Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

Philip P Chamberlain;Antonia Lopez-Girona;Karen Miller;Gilles Carmel.
Nature Structural & Molecular Biology (2014)

305 Citations

Structural basis for recruitment of human flap endonuclease 1 to PCNA.

Shigeru Sakurai;Ken Kitano;Hiroto Yamaguchi;Keisuke Hamada.
The EMBO Journal (2005)

305 Citations

Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue.

Kentaro Ihara;Sachiko Muraguchi;Masato Kato;Toshiyuki Shimizu.
Journal of Biological Chemistry (1998)

292 Citations

Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences.

Yoshifumi Fujii;Toshiyuki Shimizu;Masahiro Kusumoto;Yoshimasa Kyogoku.
The EMBO Journal (1999)

272 Citations

Structures of D14 and D14L in the strigolactone and karrikin signaling pathways

Megumi Kagiyama;Yoshinori Hirano;Tomoyuki Mori;Sun Yong Kim.
Genes to Cells (2013)

250 Citations

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.

Akiyuki Nishimura;Ken Kitano;Jun Takasaki;Masatoshi Taniguchi.
Proceedings of the National Academy of Sciences of the United States of America (2010)

244 Citations

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