D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 51 Citations 8,511 133 World Ranking 9702 National Ranking 722

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • G protein-coupled receptor
  • Biochemistry

Her main research concerns Receptor, G protein-coupled receptor, Signal transduction, G protein and Biochemistry. Evi Kostenis has included themes like Inflammation and Pharmacology in her Receptor study. Evi Kostenis has researched G protein-coupled receptor in several fields, including Cannabinoid receptor type 2, Enzyme-linked receptor, Angiotensin II, Angiotensin II receptor type 1 and Computational biology.

Her Signal transduction research incorporates themes from Cancer research and Immunology. Her research integrates issues of Protein structure and Arrestin in her study of G protein. Her Biochemistry study combines topics in areas such as Biophysics and Stereochemistry.

Her most cited work include:

  • G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor (320 citations)
  • Heterotrimeric G-proteins: a short history (315 citations)
  • Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice (313 citations)

What are the main themes of her work throughout her whole career to date?

Receptor, G protein-coupled receptor, Cell biology, Signal transduction and Stereochemistry are her primary areas of study. Her Receptor study frequently involves adjacent topics like Pharmacology. Her study in Pharmacology is interdisciplinary in nature, drawing from both Prostaglandin and Prostaglandin D2.

Evi Kostenis works mostly in the field of G protein-coupled receptor, limiting it down to topics relating to Computational biology and, in certain cases, GPR55 and Cell signaling, as a part of the same area of interest. She combines subjects such as Chemotaxis and Immunology with her study of Signal transduction. Her Stereochemistry research is multidisciplinary, incorporating elements of Potency and Allosteric regulation.

She most often published in these fields:

  • Receptor (52.27%)
  • G protein-coupled receptor (32.95%)
  • Cell biology (28.41%)

What were the highlights of her more recent work (between 2018-2021)?

  • Cell biology (28.41%)
  • Receptor (52.27%)
  • G protein (22.16%)

In recent papers she was focusing on the following fields of study:

Her primary areas of investigation include Cell biology, Receptor, G protein, Gq alpha subunit and Heterotrimeric G protein. Her work on Phosphorylation as part of general Cell biology research is frequently linked to Rational design, bridging the gap between disciplines. Her Receptor study frequently intersects with other fields, such as Endocrinology.

Evi Kostenis has researched G protein in several fields, including G protein-coupled receptor, Mutant, Transmembrane protein, HEK 293 cells and Second messenger system. Her studies in G protein-coupled receptor integrate themes in fields like Computational biology, Heterotrimeric G Protein Subunit and Endosome. Her Gq alpha subunit study is related to the wider topic of Signal transduction.

Between 2018 and 2021, her most popular works were:

  • A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. (70 citations)
  • Direct targeting of Gαq and Gα11 oncoproteins in cancer cells (35 citations)
  • Heterotrimeric Gq proteins as therapeutic targets (18 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • Biochemistry
  • Receptor

Evi Kostenis mainly investigates Cell biology, Gq alpha subunit, Heterotrimeric G protein, G protein and Signal transduction. Her Cell biology research incorporates elements of Agonist, Receptor, Glutamate receptor and Mechanism of action. Her Receptor research is multidisciplinary, relying on both Endocrinology and Pharmacology.

Her Gq alpha subunit research integrates issues from Cell signaling, Transmembrane protein, Mutagenesis, Structural similarity and Effector. Her work carried out in the field of Cell signaling brings together such families of science as Computational biology, G protein-coupled receptor, Membrane protein and Drug discovery. In general Signal transduction, her work in Focal adhesion, Hippo signaling pathway, Tyrosine phosphorylation and Hippo signaling is often linked to GNA11 linking many areas of study.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Heterotrimeric G-proteins: a short history

Graeme Milligan;Evi Kostenis.
British Journal of Pharmacology (2006)

578 Citations

G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor

Evi Kostenis;Graeme Milligan;Arthur Christopoulos;Carlos F. Sanchez-Ferrer.
Circulation (2005)

472 Citations

Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice

Jesus Gomeza;Harlan Shannon;Evi Kostenis;Christian Felder.
Proceedings of the National Academy of Sciences of the United States of America (1999)

416 Citations

A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

Maria Waldhoer;Jamie Fong;Robert M. Jones;Mary M. Lunzer.
Proceedings of the National Academy of Sciences of the United States of America (2005)

377 Citations

Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M4 muscarinic acetylcholine receptor knockout mice

Jesus Gomeza;Lu Zhang;Evi Kostenis;Christian Felder.
Proceedings of the National Academy of Sciences of the United States of America (1999)

334 Citations

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

Christoph S.N. Klose;Tanel Mahlakõiv;Jesper B. Moeller;Jesper B. Moeller;Lucille C. Rankin.
Nature (2017)

274 Citations

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements

Ralf Schröder;Nicole Janssen;Johannes Schmidt;Anna Kebig.
Nature Biotechnology (2010)

263 Citations

Identification of Nonpeptidic Urotensin II Receptor Antagonists by Virtual Screening Based on a Pharmacophore Model Derived from Structure−Activity Relationships and Nuclear Magnetic Resonance Studies on Urotensin II

Stefanie Flohr;Michael Kurz;Evi Kostenis;Alexandre Brkovich.
Journal of Medicinal Chemistry (2002)

224 Citations

Emerging roles of DP and CRTH2 in allergic inflammation

Evi Kostenis;Trond Ulven.
Trends in Molecular Medicine (2006)

214 Citations

The experimental power of FR900359 to study Gq-regulated biological processes

Ramona Schrage;Anna Lena Schmitz;Evelyn Gaffal;Suvi Annala.
Nature Communications (2015)

203 Citations

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