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D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
15437
World Ranking
7104
National Ranking
518

Overview

Evi Kostenis is affiliated with the University of Bonn in Germany. Their research primarily focuses on biochemistry, genetics, and molecular biology, with notable contributions to medicine. The scientist has published extensively in several main and subfields of study, concentrating on molecular biology, cellular and molecular neuroscience, immunology, oncology, and physiology.

Their work addresses a range of topics including receptor mechanisms and signaling, protein kinase regulation and GTPase signaling, neuropeptides and animal physiology, chemokine receptors and signaling, pancreatic function and diabetes, cell adhesion molecules research, and diabetes treatment and management.

Evi Kostenis has contributed to the scientific literature through multiple recent papers. These include:

  • Community guidelines for GPCR ligand bias: IUPHAR review 32 (2022, British Journal of Pharmacology)
  • The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides (2020, Nature Communications)
  • GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation (2022, Nature Communications)
  • Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs (2020, Molecular Cell)
  • Local IP 3 receptor-mediated Ca 2+ signals compound to direct blood flow in brain capillaries (2021, Science Advances)

Their frequent co-authors include:

  • Gabriele M. König
  • Judith Alenfelder
  • Asuka Inoue
  • Nicole Merten
  • S P H Alexander

Evi Kostenis often publishes in the following venues:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • IUPHAR/BPS Guide to Pharmacology CITE
  • UNC Libraries
  • Proceedings of the National Academy of Sciences

Best Publications

  • Heterotrimeric G-proteins: a short history

    Graeme Milligan;Evi Kostenis

  • The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

    Christoph S.N. Klose;Tanel Mahlakõiv;Jesper B. Moeller;Jesper B. Moeller;Lucille C. Rankin

  • G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor

    Evi Kostenis;Graeme Milligan;Arthur Christopoulos;Carlos F. Sanchez-Ferrer

  • Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice

    Jesus Gomeza;Harlan Shannon;Evi Kostenis;Christian Felder

  • A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

    Maria Waldhoer;Jamie Fong;Robert M. Jones;Mary M. Lunzer

  • Lack of beta-arrestin signaling in the absence of active G proteins

    Manuel Grundmann;Nicole Merten;Davide Malfacini;Asuka Inoue;Asuka Inoue

  • The experimental power of FR900359 to study Gq-regulated biological processes

    Ramona Schrage;Anna Lena Schmitz;Evelyn Gaffal;Suvi Annala

  • Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M4 muscarinic acetylcholine receptor knockout mice

    Jesus Gomeza;Lu Zhang;Evi Kostenis;Christian Felder

  • Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements

    Ralf Schröder;Nicole Janssen;Johannes Schmidt;Anna Kebig

  • Emerging roles of DP and CRTH2 in allergic inflammation

    Evi Kostenis;Trond Ulven

  • A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

    Xiaodong Feng;Xiaodong Feng;Nadia Arang;Damiano Cosimo Rigiracciolo;Damiano Cosimo Rigiracciolo;Joo Sang Lee;Joo Sang Lee

  • GPR55 ligands promote receptor coupling to multiple signalling pathways

    Christopher M Henstridge;Nariman Ab Balenga;Ralf Schröder;Julia K Kargl

  • Applying label-free dynamic mass redistribution technology to frame signaling of G protein–coupled receptors noninvasively in living cells

    Ralf Schröder;Johannes Schmidt;Stefanie Blättermann;Lucas Peters

  • GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils

    Nariman A B Balenga;Elma Aflaki;Julia Kargl;Wolfgang Platzer

  • Techniques: Promiscuous Gα proteins in basic research and drug discovery

    Evi Kostenis;Magali Waelbroeck;Graeme Milligan

  • Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity

    Johannes Antony;Kerstin Kellershohn;Marion Mohr-Andrä;Anna Kebig

  • The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

    Andreas Bock;Nicole Merten;Ramona Schrage;Clelia Dallanoce

  • Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation

    Lena Uller;Jesper Mosolff Mathiesen;Lisa Alenmyr;Magnus Korsgren

  • Rational design of dualsteric GPCR ligands: quests and promise.

    Klaus Mohr;Christian Tränkle;Evi Kostenis;Elisabetta Barocelli

  • The Novel Cellular Mechanism of Human 5-HT6 Receptor through an Interaction with Fyn

    Hyung-Mun Yun;Sunoh Kim;Sunoh Kim;Hyun-Ji Kim;Evi Kostenis

Frequent Co-Authors

Gabriele M. König
Gabriele M. König University of Bonn
Trond Ulven
Trond Ulven University of Copenhagen
Ulrike Holzgrabe
Ulrike Holzgrabe University of Würzburg
Graeme Milligan
Graeme Milligan University of Glasgow
Christa E. Müller
Christa E. Müller University of Bonn
Asuka Inoue
Asuka Inoue Tohoku University
Bernd K. Fleischmann
Bernd K. Fleischmann University of Bonn
Michael Gütschow
Michael Gütschow University of Bonn
Matthias U. Kassack
Matthias U. Kassack Heinrich Heine University Düsseldorf
Jennifer L. Whistler
Jennifer L. Whistler University of California, San Francisco

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