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Neuroscience

D-Index
46
Citations
10193
World Ranking
6622
National Ranking
2876

Overview

Jennifer L. Whistler is affiliated with the University of California, San Francisco in the United States. Their research spans multiple scientific fields including Neuroscience, Biochemistry, Genetics and Molecular Biology, and Medicine. The work focuses on understanding receptor mechanisms, signaling pathways, and neuropeptide dynamics.

Their main fields of study include:

  • Neuroscience
  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Whistler's research engages with several specialized subfields such as Molecular Biology, Cellular and Molecular Neuroscience, General Health Professions, Endocrinology, Diabetes and Metabolism, and Surgery. The topics they most frequently explore cover a broad spectrum of receptor-related and neuroscience issues, including:

  • Receptor Mechanisms and Signaling
  • Neuropeptides and Animal Physiology
  • Neurotransmitter Receptor Influence on Behavior
  • Neuroscience and Neuropharmacology Research
  • Pharmacological Receptor Mechanisms and Effects
  • Gut microbiota and health
  • Diabetes Treatment and Management

Their scholarly output includes publications in various peer-reviewed journals and venues, with frequent contributions published in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biological Psychiatry
  • Progress in Community Health Partnerships
  • UNC Libraries
  • Nature Neuroscience

Notable recent papers authored or co-authored by Jennifer L. Whistler include:

  • Pharmacological and genetic manipulations at the µ-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice, 2021, Neuropsychopharmacology
  • Unlocking opioid neuropeptide dynamics with genetically encoded biosensors, 2024, Nature Neuroscience
  • Arrestin-3 Agonism at Dopamine D3 Receptors Defines a Subclass of Second-Generation Antipsychotics That Promotes Drug Tolerance, 2023, Biological Psychiatry
  • A Balancing Act: Learning from the Past to Build a Future-Focused Opioid Strategy, 2023, Annual Review of Physiology
  • Deletion of arrestin-3 does not reduce drug-seeking behavior in a longitudinal paradigm of oral morphine self-administration, 2024, Frontiers in Pharmacology

Frequent collaborators in their research efforts include:

  • Anirudh Gaur
  • Elinor Lewis
  • Lindsey Felth
  • Randi Foxall
  • Izabella Sall

Best Publications

  • Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons

    Mark A. Ungless;Jennifer L. Whistler;Robert C. Malenka;Antonello Bonci

  • Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction

    Jennifer L Whistler;Huai-hu Chuang;Peter Chu;Lily Y Jan

  • Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization.

    Li He;Jamie Fong;Mark von Zastrow;Jennifer L Whistler

  • Modulation of Postendocytic Sorting of G Protein-Coupled Receptors

    Jennifer L. Whistler;Johan Enquist;Aaron Marley;Jamie Fong

  • Morphine-activated opioid receptors elude desensitization by β-arrestin

    Jennifer L. Whistler;Mark von Zastrow

  • Endocytosis of the Mu Opioid Receptor Reduces Tolerance and a Cellular Hallmark of Opiate Withdrawal

    Andrew K Finn;Jennifer L Whistler

  • A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

    Maria Waldhoer;Jamie Fong;Robert M. Jones;Mary M. Lunzer

  • Opioid receptors.

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  • The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence.

    Lene Martini;Jennifer L Whistler

  • GPR55 ligands promote receptor coupling to multiple signalling pathways

    Christopher M Henstridge;Nariman Ab Balenga;Ralf Schröder;Julia K Kargl

  • A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).

    Arne Heydorn;Birgitte P. Søndergaard;Bjarne Ersbøll;Birgitte Holst

  • Dopamine responsiveness is regulated by targeted sorting of D2 receptors

    Selena E. Bartlett;Johan Enquist;Johan Enquist;Frederic W. Hopf;Josephine H. Lee

  • μ-Opioid Receptors: Ligand-Dependent Activation of Potassium Conductance, Desensitization, and Internalization

    Veronica A. Alvarez;Seksiri Arttamangkul;Vu Dang;Abdallah Salem;Abdallah Salem

  • Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the G-protein-coupled receptor-associated sorting protein GASP1

    Lene Martini;Maria Waldhoer;Margareta Pusch;Viktor Kharazia

  • Real-time trafficking and signaling of the glucagon-like peptide-1 receptor.

    Sarah Noerklit Roed;Sarah Noerklit Roed;Pernille Wismann;Christina Rye Underwood;Nikolaj Kulahin

  • Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit

    Nicole A. Crowley;Daniel W. Bloodgood;J. Andrew Hardaway;Alexis M. Kendra

  • Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism

    Congcong He;Yongjie Wei;Kai Sun;Binghua Li

  • Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction.

    Jennifer L. Whistler;Mark von Zastrow

  • The Carboxyl Terminus of Human Cytomegalovirus-encoded 7 Transmembrane Receptor US28 Camouflages Agonism by Mediating Constitutive Endocytosis *

    Maria Waldhoer;Maria Waldhoer;Paola Casarosa;Mette M. Rosenkilde;Martine J. Smit

  • A Molecular Basis of Analgesic Tolerance to Cannabinoids

    Anke Tappe-Theodor;Nitin Agarwal;István Katona;Tiziana Rubino

  • An opiate cocktail that reduces morphine tolerance and dependence.

    Li He;Jennifer L. Whistler

Frequent Co-Authors

Antonello Bonci
Antonello Bonci National Institute on Drug Abuse
Selena E. Bartlett
Selena E. Bartlett Queensland University of Technology
Viktor Kharazia
Viktor Kharazia University of California, San Francisco
Yoichi Ueta
Yoichi Ueta University of Occupational and Environmental Health Japan
Michael J. Krashes
Michael J. Krashes National Institutes of Health
Michael R. Bruchas
Michael R. Bruchas University of Washington
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Lily Yeh Jan
Lily Yeh Jan University of California, San Francisco
Olivier Lichtarge
Olivier Lichtarge Baylor College of Medicine

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