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Chemistry

D-Index
61
Citations
14415
World Ranking
9182
National Ranking
658

Overview

Peter Gmeiner is affiliated with the University of Erlangen-Nuremberg in Germany. Their research primarily focuses on the areas of biochemistry, genetics, and molecular biology, with a substantial number of publications also related to neuroscience.

The main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Within these fields, their work delves into several subfields such as:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Spectroscopy
  • Materials Chemistry
  • Radiology, Nuclear Medicine and Imaging

The researcher's studies predominantly address the following topics:

  • Receptor Mechanisms and Signaling
  • Neuropeptides and Animal Physiology
  • Pharmacological Receptor Mechanisms and Effects
  • Chemical Synthesis and Analysis
  • Monoclonal and Polyclonal Antibodies Research
  • Mass Spectrometry Techniques and Applications
  • Photochromic and Fluorescence Chemistry

Peter Gmeiner has contributed to a number of prominent scientific publications. Representative recent papers include:

  • "Structure-based discovery of nonopioid analgesics acting through the α 2A -adrenergic receptor" (2022), published in Science
  • "Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR" (2020), published in Cell Research
  • "Time-resolved cryo-EM of G-protein activation by a GPCR" (2024), published in Nature
  • "Activation of the α2B adrenoceptor by the sedative sympatholytic dexmedetomidine" (2020), published in Nature Chemical Biology
  • "An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor" (2020), published in Nature Chemical Biology

Frequent publication venues where Peter Gmeiner's work appears include:

  • Journal of Medicinal Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Angewandte Chemie International Edition
  • Angewandte Chemie

Their collaborative network features several frequent co-authors, specifically:

  • Harald Hübner
  • Dorothée Weikert
  • Brian K. Kobilka
  • Stefan Löber
  • Maximilian F. Schmidt

Best Publications

  • Activation and allosteric modulation of a muscarinic acetylcholine receptor

    Andrew C. Kruse;Aaron M. Ring;Aashish Manglik;Jianxin Hu

  • Structural insights into µ-opioid receptor activation

    Weijiao Huang;Aashish Manglik;A. J. Venkatakrishnan;Toon Laeremans

  • Structure and function of an irreversible agonist-β2 adrenoceptor complex

    Daniel M. Rosenbaum;Cheng Zhang;Joseph A. Lyons;Joseph A. Lyons;Ralph Holl

  • Conjugated Enynes as Nonaromatic Catechol Bioisosteres: Synthesis, Binding Experiments, and Computational Studies of Novel Dopamine Receptor Agonists Recognizing Preferentially the D3 Subtype

    Harald Hübner;Christian Haubmann;Wolfgang Utz;Peter Gmeiner

  • Interactive SAR Studies: Rational Discovery of Super-Potent and Highly Selective Dopamine D3 Receptor Antagonists and Partial Agonists

    Laura Bettinetti;Karin Schlotter;Harald Hübner;Peter Gmeiner

  • Click linker: efficient and high-yielding synthesis of a new family of SPOS resins by 1,3-dipolar cycloaddition.

    Stefan Löber;Pilar Rodriguez-Loaiza;Peter Gmeiner

  • Labeling and Glycosylation of Peptides Using Click Chemistry: A General Approach to 18F‐Glycopeptides as Effective Imaging Probes for Positron Emission Tomography

    Simone Maschauer;Jürgen Einsiedel;Roland Haubner;Carsten Hocke

  • An efficient and practical total synthesis of (+)-vincamine from L-aspartic acid

    Peter Gmeiner;Paul L. Feldman;Margaret Y. Chu-Moyer;Henry Rapoport

  • Class A G-Protein-Coupled Receptor (GPCR) Dimers and Bivalent Ligands

    Christine Hiller;Julia Kühhorn;Peter Gmeiner

  • GPCR crystal structures: Medicinal chemistry in the pocket.

    Jeremy Shonberg;Ralf C. Kling;Peter Gmeiner;Stefan Löber

  • Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).

    Stefan Löber;Harald Hübner;Wolfgang Utz;Peter Gmeiner

  • Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.

    Stefan Löber;Harald Hübner;Peter Gmeiner

  • Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR

    Xinyu Xu;Jonas Kaindl;Mary J. Clark;Harald Hübner

  • Recent advances in the search for D3- and D4-selective drugs: probes, models and candidates

    Stefan Löber;Harald Hübner;Nuska Tschammer;Peter Gmeiner

  • Chirospecific Synthesis of Spirocyclic β-Lactams and Their Characterization as Potent Type II β-Turn Inducing Peptide Mimetics

    Holger Bittermann;Peter Gmeiner

  • Covalent agonists for studying G protein-coupled receptor activation

    Dietmar Weichert;Andrew C. Kruse;Aashish Manglik;Christine Hiller

  • Structure-guided development of heterodimer-selective GPCR ligands

    Harald Hübner;Tamara Schellhorn;Marie Gienger;Carolin Schaab

  • Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent‐resistant membrane compartments

    Ralf Klingenstein;Stefan Löber;Pekka Kujala;Susan Godsave

  • The structural evolution of dopamine D3 receptor ligands: structure-activity relationships and selected neuropharmacological aspects.

    Frank Boeckler;Peter Gmeiner

  • Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus.

    Philip Seeman;Alan Wilson;Alan Wilson;Peter Gmeiner;Shitij Kapur;Shitij Kapur

  • Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.

    Katharina Ehrlich;Angela Götz;Stefan Bollinger;Nuska Tschammer

Frequent Co-Authors

Harald Hübner
Harald Hübner University of Erlangen-Nuremberg
Brian K. Kobilka
Brian K. Kobilka Stanford University
William I. Weis
William I. Weis Stanford University
Antonio Argiolas
Antonio Argiolas University of Cagliari
Frank W. Heinemann
Frank W. Heinemann University of Erlangen-Nuremberg
Jan Steyaert
Jan Steyaert Vrije Universiteit Brussel
Maria Rosaria Melis
Maria Rosaria Melis University of Cagliari
Roger K. Sunahara
Roger K. Sunahara University of California, San Diego
Johannes Kornhuber
Johannes Kornhuber University of Göttingen
Andrew C. Kruse
Andrew C. Kruse Harvard University

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