World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
21949
World Ranking
11694
National Ranking
5029

Overview

Andrew C. Kruse is affiliated with Harvard University in the United States. Their research spans multiple aspects of biochemistry, genetics, and molecular biology, with significant contributions also in the field of medicine.

Their work features prominently in the study of receptor mechanisms and signaling, with additional focus on monoclonal and polyclonal antibodies research. Other main research topics include bacterial genetics and biotechnology, neuropeptides and animal physiology, pharmacological receptor mechanisms and effects, antibiotic resistance in bacteria, and pregnancy-related medical research.

Andrew C. Kruse has published extensively, with frequent contributions to the following publication venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science
  • Nature Communications
  • Nature
  • Proceedings of the National Academy of Sciences

Among their recent papers are:

  • Protein design and variant prediction using autoregressive generative models, 2021, Nature Communications
  • Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR, 2020, Science
  • Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor, 2020, Science
  • Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2, 2021, Science
  • Structures of the σ2 receptor enable docking for bioactive ligand discovery, 2021, Nature

The scientist collaborates regularly with several researchers, the most frequent co-authors being:

  • Meredith A. Skiba
  • Morgan S. A. Gilman
  • Debora S. Marks
  • Assaf Alon
  • Conor McMahon

Andrew C. Kruse's research encompasses a variety of subfields within biochemistry and molecular biology, including molecular biology, radiology, nuclear medicine and imaging, immunology, genetics, and cellular and molecular neuroscience.

Best Publications

  • Crystal structure of the β2 adrenergic receptor-Gs protein complex.

    Søren G. F. Rasmussen;Brian T. DeVree;Yaozhong Zou;Andrew C. Kruse

  • Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

    Aashish Manglik;Andrew C. Kruse;Tong Sun Kobilka;Foon Sun Thian

  • Activation and allosteric modulation of a muscarinic acetylcholine receptor

    Andrew C. Kruse;Aaron M. Ring;Aashish Manglik;Jianxin Hu

  • Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.

    Kazuko Haga;Andrew C. Kruse;Hidetsugu Asada;Takami Yurugi-Kobayashi

  • Structure and dynamics of the M3 muscarinic acetylcholine receptor

    Andrew C. Kruse;Jianxin Hu;Albert C. Pan;Daniel H. Arlow

  • Structure of the δ-opioid receptor bound to naltrindole

    Sébastien Granier;Aashish Manglik;Andrew C. Kruse;Tong Sun Kobilka

  • Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody.

    Aaron M. Ring;Aashish Manglik;Andrew C. Kruse;Michael D. Enos

  • SEDS proteins are a widespread family of bacterial cell wall polymerases

    Alexander J. Meeske;Eammon P. Riley;William P. Robins;Tsuyoshi Uehara

  • Maltose–neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

    Pil Seok Chae;Søren G F Rasmussen;Rohini R. Rana;Kamil Gotfryd

  • Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

    Arun K. Shukla;Aashish Manglik;Andrew C Kruse;Kunhong Xiao

  • Crystal structure of the human σ1 receptor

    Hayden R. Schmidt;Sanduo Zheng;Esin Gurpinar;Antoine Koehl

  • Yeast surface display platform for rapid discovery of conformationally selective nanobodies

    Conor McMahon;Alexander S. Baier;Roberta Pascolutti;Marcin Wegrecki

  • Muscarinic acetylcholine receptors: novel opportunities for drug development

    Andrew C. Kruse;Brian K. Kobilka;Dinesh Gautam;Patrick M. Sexton

  • Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

    Roy L. Maute;Sydney R. Gordon;Aaron T. Mayer;Melissa N. McCracken

  • FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein.

    Atsushi Taguchi;Michael A. Welsh;Lindsey S. Marmont;Wonsik Lee;Wonsik Lee

  • Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

    Dean P Staus;Ryan T Strachan;Aashish Manglik;Biswaranjan Pani

  • T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

    Jarrett J. Adams;Samanthi Narayanan;Baoyu Liu;Michael E. Birnbaum

  • Protein design and variant prediction using autoregressive generative models

    Jung-Eun Shin;Adam J. Riesselman;Aaron W. Kollasch;Conor McMahon

  • Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket.

    Brandon Zimmerman;Brendan Kelly;Brian J. McMillan;Tom C.M. Seegar

  • A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology

    Haiwei Chen;Phu-Khat Nwe;Yi Yang;Connor E. Rosen

Frequent Co-Authors

Brian K. Kobilka
Brian K. Kobilka Stanford University
Aaron M. Ring
Aaron M. Ring Yale University
Robert J. Lefkowitz
Robert J. Lefkowitz Duke University
Debora S. Marks
Debora S. Marks Harvard University
Thomas G. Bernhardt
Thomas G. Bernhardt Harvard University
William I. Weis
William I. Weis Stanford University
Stephen C. Blacklow
Stephen C. Blacklow Harvard University
David Z. Rudner
David Z. Rudner Harvard University
Samuel H. Gellman
Samuel H. Gellman University of Wisconsin–Madison
Daniel Kahne
Daniel Kahne Harvard University

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