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Thomas G. Bernhardt

Thomas G. Bernhardt

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
12914
World Ranking
13114
National Ranking
5591

Overview

Thomas G. Bernhardt is affiliated with Harvard University in the United States. Their research primarily falls within the broad field of Biochemistry, Genetics and Molecular Biology, contributing to over 100 publications in this area. Their work spans multiple specialized subfields, including Molecular Biology, Genetics, Ecology, Molecular Medicine, and Endocrinology.

The scientist has contributed to advancing understanding in several key topics such as Bacterial Genetics and Biotechnology, Bacteriophages and microbial interactions, Antibiotic Resistance in Bacteria, Genomics and Phylogenetic Studies, RNA and protein synthesis mechanisms, Bacterial biofilms and quorum sensing, and specifically, studies on Escherichia coli.

Bernhardt's scholarly output includes numerous papers published in diverse venues. Frequent publication platforms include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • mBio
  • Nature Microbiology
  • Zenodo (CERN European Organization for Nuclear Research)

Selected recent papers reflect the scope and focus of their work. These include:

  • An Essential Membrane Protein Modulates the Proteolysis of LpxC to Control Lipopolysaccharide Synthesis in Escherichia coli, 2020, mBio
  • Growth and Division of the Peptidoglycan Matrix, 2021, Annual Review of Microbiology
  • Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex, 2020, Nature Microbiology
  • The Tol-Pal system is required for peptidoglycan-cleaving enzymes to complete bacterial cell division, 2020, Proceedings of the National Academy of Sciences
  • Cell wall synthesis and remodelling dynamics determine division site architecture and cell shape in Escherichia coli, 2022, Nature Microbiology

Bernhardt frequently collaborates with a select group of coauthors, including:

  • Elayne M. Fivenson
  • Suzanne Walker
  • Andrea Vettiger
  • Andrew C. Kruse
  • Irina Shlosman

The body of work by Thomas G. Bernhardt reflects a focus on bacterial cell biology and genetics, in particular mechanisms related to cell wall synthesis, bacterial division, and microbial interaction processes. Their collaborative network and publication record indicate contribution to both fundamental and applied microbiological research fields.

Best Publications

  • SlmA, a Nucleoid-Associated, FtsZ Binding Protein Required for Blocking Septal Ring Assembly over Chromosomes in E. coli

    Thomas G. Bernhardt;Piet A.J. de Boer

  • Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery.

    Hongbaek Cho;Tsuyoshi Uehara;Thomas G. Bernhardt

  • SEDS proteins are a widespread family of bacterial cell wall polymerases

    Alexander J. Meeske;Eammon P. Riley;William P. Robins;Tsuyoshi Uehara

  • The Escherichia coli amidase AmiC is a periplasmic septal ring component exported via the twin-arginine transport pathway.

    Thomas G. Bernhardt;Piet A. J. de Boer

  • RodZ (YfgA) is required for proper assembly of the MreB actin cytoskeleton and cell shape in E. coli.

    Felipe O Bendezú;Cynthia A Hale;Thomas G Bernhardt;Piet A J de Boer

  • MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis

    Lok To Sham;Emily K. Butler;Matthew D. Lebar;Daniel Kahne

  • Daughter cell separation is controlled by cytokinetic ring‐activated cell wall hydrolysis

    Tsuyoshi Uehara;Katherine R Parzych;Thuy Dinh;Thomas G Bernhardt

  • Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases

    Catherine Paradis-Bleau;Monica Markovski;Tsuyoshi Uehara;Tania J. Lupoli

  • FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein.

    Atsushi Taguchi;Michael A. Welsh;Lindsey S. Marmont;Wonsik Lee;Wonsik Lee

  • Bacterial cell wall biogenesis is mediated by SEDS and PBP polymerase families functioning semi-autonomously.

    Hongbaek Cho;Carl N. Wivagg;Mrinal Kapoor;Zachary Barry

  • Screening for synthetic lethal mutants in Escherichia coli and identification of EnvC (YibP) as a periplasmic septal ring factor with murein hydrolase activity.

    Thomas G. Bernhardt;Piet A. J. De Boer

  • Nucleoid occlusion factor SlmA is a DNA-activated FtsZ polymerization antagonist

    Hongbaek Cho;Heather R. McManus;Simon L. Dove;Thomas G. Bernhardt

  • An Essential Membrane Protein Modulates the Proteolysis of LpxC to Control Lipopolysaccharide Synthesis in Escherichia coli

    Elayne M. Fivenson;Thomas G. Bernhardt;Thomas G. Bernhardt

  • Self-Enhanced Accumulation of FtsN at Division Sites and Roles for Other Proteins with a SPOR Domain (DamX, DedD, and RlpA) in Escherichia coli Cell Constriction

    Matthew A. Gerding;Bing Liu;Felipe O. Bendezú;Cynthia A. Hale

  • LytM-Domain Factors Are Required for Daughter Cell Separation and Rapid Ampicillin-Induced Lysis in Escherichia coli

    Tsuyoshi Uehara;Thuy Dinh;Thomas G. Bernhardt

  • An ATP-binding cassette transporter-like complex governs cell-wall hydrolysis at the bacterial cytokinetic ring.

    Desirée C. Yang;Nick T. Peters;Katherine R. Parzych;Tsuyoshi Uehara

  • MurJ and a novel lipid II flippase are required for cell wall biogenesis in Bacillus subtilis.

    Alexander J. Meeske;Lok-To Sham;Harvey Kimsey;Byoung-Mo Koo

  • Genetic evidence that the bacteriophage φX174 lysis protein inhibits cell wall synthesis

    Thomas G. Bernhardt;William D. Roof;Ry Young

  • A Protein Antibiotic in the Phage Qβ Virion: Diversity in Lysis Targets

    Thomas G. Bernhardt;Ing-Nang Wang;Douglas K. Struck;Ryland Young

  • FtsEX is required for CwlO peptidoglycan hydrolase activity during cell wall elongation in Bacillus subtilis.

    Jeffrey Meisner;Paula Montero Llopis;Lok To Sham;Ethan Garner

Frequent Co-Authors

David Z. Rudner
David Z. Rudner Harvard University
Suzanne Walker
Suzanne Walker Harvard University
Andrew C. Kruse
Andrew C. Kruse Harvard University
Daniel Kahne
Daniel Kahne Harvard University
Thomas R. Ioerger
Thomas R. Ioerger Texas A&M University
Ry Young
Ry Young Texas A&M University
Andy Fenton
Andy Fenton University of Liverpool
Michael Welsh
Michael Welsh Uppsala University
Debora S. Marks
Debora S. Marks Harvard University
Carolyn R. Bertozzi
Carolyn R. Bertozzi Stanford University

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