World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
95
Citations
29979
World Ranking
1641
National Ranking
628

Biology and Biochemistry

D-Index
96
Citations
30927
World Ranking
1839
National Ranking
1011

Research.com Recognitions

  • 2019 - Member of the National Academy of Sciences
  • 2012 - Fellow of the American Academy of Arts and Sciences
  • 1992 - Fellow of Alfred P. Sloan Foundation

Overview

Daniel Kahne is affiliated with Harvard University in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with a significant focus on Molecular Biology, Genetics, Molecular Medicine, Ecology, and Infectious Diseases.

Their recent publications cover diverse aspects of molecular mechanisms related to bacterial membranes, antibiotic action, and protein folding. Notable papers include:

  • A novel antibiotic class targeting the lipopolysaccharide transporter, 2024, Nature
  • Structure of a nascent membrane protein as it folds on the BAM complex, 2020, Nature
  • Assembly and Maintenance of Lipids at the Bacterial Outer Membrane, 2020, Chemical Reviews
  • Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex, 2020, Nature Microbiology
  • A new antibiotic traps lipopolysaccharide in its intermembrane transporter, 2024, Nature

The main topics addressed in their work include bacterial genetics and biotechnology, RNA and protein synthesis mechanisms, antibiotic resistance in bacteria, bacteriophages and microbial interactions, protein structure and dynamics, enzyme structure and function, and drug transport and resistance mechanisms.

They have frequently published in several scientific venues, with the largest number of papers appearing in Nature, followed by Nature Microbiology, bioRxiv (Cold Spring Harbor Laboratory), Chemical Reviews, and the Journal of the American Chemical Society.

  • Nature
  • Nature Microbiology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Chemical Reviews
  • Journal of the American Chemical Society

Throughout their career, Daniel Kahne has collaborated with several researchers repeatedly. Frequent co-authors include Vadim Baidin, Suzanne Walker, Patrizio Mattei, Christoph Bieniossek, and Thomas Clairfeuille.

  • Vadim Baidin
  • Suzanne Walker
  • Patrizio Mattei
  • Christoph Bieniossek
  • Thomas Clairfeuille

Daniel Kahne has been recognized with several honors, including election as a Member of the National Academy of Sciences in 2019, Fellowship of the American Academy of Arts and Sciences in 2012, and Fellowship of the Alfred P. Sloan Foundation in 1992.

Best Publications

  • The Bacterial Cell Envelope

    Thomas J. Silhavy;Daniel Kahne;Suzanne Walker

  • Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli

    Tao Wu;Tao Wu;Juliana Malinverni;Natividad Ruiz;Seokhee Kim;Seokhee Kim

  • Glycopeptide and Lipoglycopeptide Antibiotics

    Dan Kahne;Catherine Leimkuhler;Wei Lu;Christopher Walsh

  • Glycosylation of unreactive substrates

    Daniel Kahne;Suzanne Walker;Yuan Cheng;Donna Van Engen

  • Advances in understanding bacterial outer-membrane biogenesis

    Natividad Ruiz;Daniel Kahne;Thomas J. Silhavy

  • Defining the roles of the periplasmic chaperones SurA, Skp, and DegP in Escherichia coli.

    Joseph G. Sklar;Tao Wu;Daniel Kahne;Thomas J. Silhavy

  • SEDS proteins are a widespread family of bacterial cell wall polymerases

    Alexander J. Meeske;Eammon P. Riley;William P. Robins;Tsuyoshi Uehara

  • Structure and function of an essential component of the outer membrane protein assembly machine.

    Seokhee Kim;Juliana C. Malinverni;Piotr Sliz;Thomas J. Silhavy

  • Identification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coli

    Tao Wu;Andrew C. McCandlish;Luisa S. Gronenberg;Shu-Sin Chng

  • Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala.

    Min Ge;Zhong Chen;H. Russell;Onishi

  • β-Barrel Membrane Protein Assembly by the Bam Complex

    Christine L. Hagan;Thomas J. Silhavy;Daniel Kahne

  • Parallel Synthesis and Screening of a Solid Phase Carbohydrate Library

    Rui Liang;Lin Yan;Jennifer Loebach;Min Ge

  • Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model.

    Suguru Okuda;David J. Sherman;Thomas J. Silhavy;Natividad Ruiz

  • MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis

    Lok To Sham;Emily K. Butler;Matthew D. Lebar;Daniel Kahne

  • YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli

    Juliana C. Malinverni;John Werner;Seokhee Kim;Joseph G. Sklar

  • On the essentiality of lipopolysaccharide to Gram-negative bacteria.

    Ge Zhang;Timothy C Meredith;Daniel Kahne

  • Chemical conditionality: a genetic strategy to probe organelle assembly.

    Natividad Ruiz;Brian Falcone;Daniel Kahne;Daniel Kahne;Thomas J. Silhavy

  • Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli.

    Joseph G. Sklar;Tao Wu;Luisa S. Gronenberg;Juliana C. Malinverni

  • Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases

    Catherine Paradis-Bleau;Monica Markovski;Tsuyoshi Uehara;Tania J. Lupoli

  • FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein.

    Atsushi Taguchi;Michael A. Welsh;Lindsey S. Marmont;Wonsik Lee;Wonsik Lee

  • Transport of lipopolysaccharide across the cell envelope: the long road of discovery

    Natividad Ruiz;Daniel Kahne;Thomas J. Silhavy

Frequent Co-Authors

Suzanne Walker
Suzanne Walker Harvard University
Natividad Ruiz
Natividad Ruiz The Ohio State University
Thomas J. Silhavy
Thomas J. Silhavy Princeton University
Christopher T. Walsh
Christopher T. Walsh Stanford University
Thomas G. Bernhardt
Thomas G. Bernhardt Harvard University
Dan Yang
Dan Yang University of Hong Kong
Andrew C. Kruse
Andrew C. Kruse Harvard University
Wei Lu
Wei Lu University of Michigan–Ann Arbor
Michael Welsh
Michael Welsh Uppsala University
David Z. Rudner
David Z. Rudner Harvard University

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