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Chemistry

D-Index
73
Citations
17020
World Ranking
5043
National Ranking
122

Biology and Biochemistry

D-Index
73
Citations
17029
World Ranking
6012
National Ranking
155

Overview

Eefjan Breukink is affiliated with Utrecht University in the Netherlands and has an extensive publication record in the field of biochemistry, genetics, and molecular biology. Their research primarily covers molecular biology and genetics, with notable contributions to food science, ecology, and spectroscopy as well.

The scientist's recent research papers demonstrate a focus on antimicrobial mechanisms and bacterial cell envelope studies. Key publications include:

  • Teixobactin kills bacteria by a two-pronged attack on the cell envelope, 2022, Nature
  • An antibiotic from an uncultured bacterium binds to an immutable target, 2023, Cell
  • Mode of action of teixobactins in cellular membranes, 2020, Nature Communications
  • Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli, 2020, The EMBO Journal
  • An Engineered Double Lipid II Binding Motifs-Containing Lantibiotic Displays Potent and Selective Antimicrobial Activity against Enterococcus faecium, 2020, Antimicrobial Agents and Chemotherapy

Their research spans a range of topics, including:

  • Bacterial Genetics and Biotechnology
  • Probiotics and Fermented Foods
  • Bacteriophages and microbial interactions
  • Lipid Membrane Structure and Behavior
  • Genomics and Phylogenetic Studies
  • Enzyme Structure and Function
  • Antimicrobial Peptides and Activities

Frequent co-authors in their work include Lila M. Gierasch, F. Peter Guengerich, Ruma Banerjee, Roger Colbran, and Peter Cresswell, each collaborating on multiple publications. These collaborations reflect active engagement in interdisciplinary research within molecular biology and biochemistry.

Eefjan Breukink's articles appear regularly in several publication venues, mainly:

  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biochimica et Biophysica Acta (BBA) - Biomembranes
  • Biophysical Journal
  • Frontiers in Microbiology

The scientist's work has accumulated citations across different studies, including 177 citations for a 2022 Nature article on teixobactin, 107 citations for a 2023 Cell article on antibiotics, 94 citations for a 2020 Nature Communications study, and other contributions cited at various levels.

Best Publications

  • Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic

    E. Breukink;I. Wiedemann;C. van Kraaij;O. P. Kuipers

  • Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity

    Wiedemann;E Breukink;C van Kraaij;Oscar Kuipers

  • Lipid II as a target for antibiotics

    Eefjan Breukink;Ben de Kruijff

  • The Nisin-Lipid II Complex Reveals a Pyrophosphate Cage that Provides a Blueprint for Novel Antibiotics

    Shang-Te D Hsu;Eefjan Breukink;Eugene Tischenko;Mandy A G Lutters

  • An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II

    Hester E. Hasper;Naomi E. Kramer;Naomi E. Kramer;James L. Smith;J. D. Hillman

  • Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins

    Athanasios Typas;Manuel Banzhaf;Bart van den Berg van Saparoea;Jolanda Verheul

  • Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes.

    Eefjan Breukink;Hester E. van Heusden;Pauline J. Vollmerhaus;Ewa Swiezewska

  • The lantibiotic nisin, a special case or not?

    Eefjan Breukink;Ben de Kruijff

  • Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane.

    Tamimount Mohammadi;Vincent van Dam;Robert Sijbrandi;Thierry Vernet

  • Antibacterial photodynamic therapy: overview of a promising approach to fight antibiotic-resistant bacterial infections.

    Yaou Liu;Rong Qin;Sebastiaan A. J. Zaat;Eefjan Breukink

  • Assembly and stability of nisin-lipid II pores.

    Hester Emilie Hasper;Ben de Kruijff;Eefjan Breukink

  • Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane.

    Yvonne M. te Welscher;Hendrik H. ten Napel;Miriam Masià Balagué;Cleiton M. Souza

  • The C-Terminal Region of Nisin Is Responsible for the Initial Interaction of Nisin with the Target Membrane†

    Eefjan Breukink;Cindy van Kraaij;Rudy A. Demel;Roland J. Siezen

  • Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II

    Erik de Leeuw;Changqing Li;Pengyun Zeng;Chong Li

  • SecA insertion into phospholipids is stimulated by negatively charged lipids and inhibited by ATP: a monolayer study.

    Eefjan Breukink;Rudy A. Demel;Gerda De Korte-Kool;Ben De Kruijff

  • Teixobactin kills bacteria by a two-pronged attack on the cell envelope

    Unknown

  • Molecular model for the solubilization of membranes into nanodisks by styrene maleic Acid copolymers.

    Stefan Scheidelaar;Martijn C. Koorengevel;Juan Dominguez Pardo;Johannes D. Meeldijk

  • Cooperativity of peptidoglycan synthases active in bacterial cell elongation

    Manuel Banzhaf;Bart van den Berg van Saparoea;Mohammed Terrak;Claudine Fraipont

  • Activities and regulation of peptidoglycan synthases

    Alexander J F Egan;Jacob Biboy;Inge van 't Veer;Eefjan Breukink

  • Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

    Andrew N Gray;Alexander J F Egan;Inge L van't Veer;Jolanda Verheul

  • The C Terminus of SecA Is Involved in Both Lipid Binding and SecB Binding

    Eefjan Breukink;Nico Nouwen;Anne van Raalte;Shoji Mizushima

  • Identification of FtsW as a transporter of lipid- linked cell wall precursors across the membrane This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resultingworkunderthesameorsimilarlicensetothisone.Theworkmustbeattributedbacktotheoriginalauthorand commercial use is not permitted without specific permission.

    Tamimount Mohammadi;Vincent van Dam;Robert Sijbrandi;Thierry Vernet

Frequent Co-Authors

Waldemar Vollmer
Waldemar Vollmer Newcastle University
Rob M. J. Liskamp
Rob M. J. Liskamp University of Glasgow
Oscar P. Kuipers
Oscar P. Kuipers University of Groningen
Roland J. Pieters
Roland J. Pieters Utrecht University
Alexandre M. J. J. Bonvin
Alexandre M. J. J. Bonvin Utrecht University
Rudy A. Demel
Rudy A. Demel Utrecht University
Robert Kaptein
Robert Kaptein Utrecht University
Thierry Vernet
Thierry Vernet French Alternative Energies and Atomic Energy Commission (CEA)
B. de Kruijff
B. de Kruijff Utrecht University
Dirk T. S. Rijkers
Dirk T. S. Rijkers Utrecht University

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