Eefjan Breukink mainly focuses on Biochemistry, Lipid II, Peptidoglycan, Nisin and Lantibiotics. His Lipid II study incorporates themes from Antibiotics, Stereochemistry, Peptide and Membrane lipids. His Peptidoglycan research is multidisciplinary, relying on both Bacterial cell structure, Bacterial outer membrane, Cell biology, Peptidoglycan glycosyltransferase and ATP synthase.
Eefjan Breukink focuses mostly in the field of Peptidoglycan glycosyltransferase, narrowing it down to matters related to Cell division and, in some cases, Penicillin binding proteins. The Nisin study combines topics in areas such as Lanthionine and Membrane. His Lantibiotics study integrates concerns from other disciplines, such as Amino acid, Vancomycin and Teixobactin.
His primary areas of investigation include Biochemistry, Lipid II, Peptidoglycan, Lantibiotics and Nisin. Biochemistry is frequently linked to Microbiology in his study. His study in Lipid II is interdisciplinary in nature, drawing from both Glycosyltransferase, Antibiotics, Stereochemistry and Antimicrobial peptides.
His research integrates issues of Cell division, Penicillin binding proteins, Bacterial cell structure and Cell biology in his study of Peptidoglycan. His study in the fields of Mutacin 1140 under the domain of Lantibiotics overlaps with other disciplines such as Micelle. He has included themes like Lanthionine, Bacteriocin, Combinatorial chemistry and Pyrophosphate in his Nisin study.
Eefjan Breukink spends much of his time researching Peptidoglycan, Biochemistry, Lipid II, Bacterial cell structure and Penicillin binding proteins. His Peptidoglycan study combines topics from a wide range of disciplines, such as Cell division, ATP synthase and Cell biology. His Biochemistry research includes elements of Bacillus subtilis and Staphylococcus aureus.
His Lipid II research incorporates themes from Antibiotics, Lantibiotics, Mode of action and Peptide, Antimicrobial peptides. His Lantibiotics research is included under the broader classification of Nisin. His study looks at the relationship between Bacterial cell structure and topics such as Activator, which overlap with Lipid bilayer and C-terminus.
Eefjan Breukink mostly deals with Peptidoglycan, Cell wall, Bacterial cell structure, Cell biology and Biochemistry. His research in Peptidoglycan is mostly concerned with Lipid II. Eefjan Breukink combines subjects such as Ring and Stereochemistry with his study of Cell wall.
As a member of one scientific family, Eefjan Breukink mostly works in the field of Bacterial cell structure, focusing on Cell and, on occasion, Lipopolysaccharide and Cytoplasm. Eefjan Breukink works mostly in the field of Cell biology, limiting it down to topics relating to Glycosyltransferase and, in certain cases, Peptide and Allosteric regulation. Eefjan Breukink studies In vitro which is a part of Biochemistry.
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Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic
E. Breukink;I. Wiedemann;C. van Kraaij;O. P. Kuipers.
Science (1999)
Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity
Wiedemann;E Breukink;C van Kraaij;Oscar Kuipers.
Journal of Biological Chemistry (2001)
Lipid II as a target for antibiotics
Eefjan Breukink;Ben de Kruijff.
Nature Reviews Drug Discovery (2006)
The Nisin-Lipid II Complex Reveals a Pyrophosphate Cage that Provides a Blueprint for Novel Antibiotics
Shang-Te D Hsu;Eefjan Breukink;Eugene Tischenko;Mandy A G Lutters.
Nature Structural & Molecular Biology (2004)
An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II
Hester E. Hasper;Naomi E. Kramer;Naomi E. Kramer;James L. Smith;J. D. Hillman.
Science (2006)
The lantibiotic nisin, a special case or not?
Eefjan Breukink;Ben de Kruijff.
Biochimica et Biophysica Acta (1999)
Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane.
Tamimount Mohammadi;Vincent van Dam;Robert Sijbrandi;Thierry Vernet.
The EMBO Journal (2011)
Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins
Athanasios Typas;Manuel Banzhaf;Bart van den Berg van Saparoea;Jolanda Verheul.
Cell (2010)
Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes.
Eefjan Breukink;Hester E. van Heusden;Pauline J. Vollmerhaus;Ewa Swiezewska.
Journal of Biological Chemistry (2003)
Assembly and stability of nisin-lipid II pores.
Hester Emilie Hasper;Ben de Kruijff;Eefjan Breukink.
Biochemistry (2004)
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