D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 64 Citations 13,635 171 World Ranking 5090 National Ranking 116
Biology and Biochemistry D-index 64 Citations 13,756 178 World Ranking 6286 National Ranking 147

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Biochemistry
  • Amino acid

Eefjan Breukink mainly focuses on Biochemistry, Lipid II, Peptidoglycan, Nisin and Lantibiotics. His Lipid II study incorporates themes from Antibiotics, Stereochemistry, Peptide and Membrane lipids. His Peptidoglycan research is multidisciplinary, relying on both Bacterial cell structure, Bacterial outer membrane, Cell biology, Peptidoglycan glycosyltransferase and ATP synthase.

Eefjan Breukink focuses mostly in the field of Peptidoglycan glycosyltransferase, narrowing it down to matters related to Cell division and, in some cases, Penicillin binding proteins. The Nisin study combines topics in areas such as Lanthionine and Membrane. His Lantibiotics study integrates concerns from other disciplines, such as Amino acid, Vancomycin and Teixobactin.

His most cited work include:

  • Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic (630 citations)
  • Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity (542 citations)
  • Lipid II as a target for antibiotics. (501 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Biochemistry, Lipid II, Peptidoglycan, Lantibiotics and Nisin. Biochemistry is frequently linked to Microbiology in his study. His study in Lipid II is interdisciplinary in nature, drawing from both Glycosyltransferase, Antibiotics, Stereochemistry and Antimicrobial peptides.

His research integrates issues of Cell division, Penicillin binding proteins, Bacterial cell structure and Cell biology in his study of Peptidoglycan. His study in the fields of Mutacin 1140 under the domain of Lantibiotics overlaps with other disciplines such as Micelle. He has included themes like Lanthionine, Bacteriocin, Combinatorial chemistry and Pyrophosphate in his Nisin study.

He most often published in these fields:

  • Biochemistry (57.06%)
  • Lipid II (42.37%)
  • Peptidoglycan (35.03%)

What were the highlights of his more recent work (between 2017-2021)?

  • Peptidoglycan (35.03%)
  • Biochemistry (57.06%)
  • Lipid II (42.37%)

In recent papers he was focusing on the following fields of study:

Eefjan Breukink spends much of his time researching Peptidoglycan, Biochemistry, Lipid II, Bacterial cell structure and Penicillin binding proteins. His Peptidoglycan study combines topics from a wide range of disciplines, such as Cell division, ATP synthase and Cell biology. His Biochemistry research includes elements of Bacillus subtilis and Staphylococcus aureus.

His Lipid II research incorporates themes from Antibiotics, Lantibiotics, Mode of action and Peptide, Antimicrobial peptides. His Lantibiotics research is included under the broader classification of Nisin. His study looks at the relationship between Bacterial cell structure and topics such as Activator, which overlap with Lipid bilayer and C-terminus.

Between 2017 and 2021, his most popular works were:

  • Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect. (54 citations)
  • High-resolution NMR studies of antibiotics in cellular membranes (45 citations)
  • Mechanisms of Incorporation for D-Amino Acid Probes That Target Peptidoglycan Biosynthesis. (36 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Amino acid
  • Biochemistry

Eefjan Breukink mostly deals with Peptidoglycan, Cell wall, Bacterial cell structure, Cell biology and Biochemistry. His research in Peptidoglycan is mostly concerned with Lipid II. Eefjan Breukink combines subjects such as Ring and Stereochemistry with his study of Cell wall.

As a member of one scientific family, Eefjan Breukink mostly works in the field of Bacterial cell structure, focusing on Cell and, on occasion, Lipopolysaccharide and Cytoplasm. Eefjan Breukink works mostly in the field of Cell biology, limiting it down to topics relating to Glycosyltransferase and, in certain cases, Peptide and Allosteric regulation. Eefjan Breukink studies In vitro which is a part of Biochemistry.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic

E. Breukink;I. Wiedemann;C. van Kraaij;O. P. Kuipers.
Science (1999)

978 Citations

Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity

Wiedemann;E Breukink;C van Kraaij;Oscar Kuipers.
Journal of Biological Chemistry (2001)

836 Citations

Lipid II as a target for antibiotics

Eefjan Breukink;Ben de Kruijff.
Nature Reviews Drug Discovery (2006)

788 Citations

The Nisin-Lipid II Complex Reveals a Pyrophosphate Cage that Provides a Blueprint for Novel Antibiotics

Shang-Te D Hsu;Eefjan Breukink;Eugene Tischenko;Mandy A G Lutters.
Nature Structural & Molecular Biology (2004)

592 Citations

An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II

Hester E. Hasper;Naomi E. Kramer;Naomi E. Kramer;James L. Smith;J. D. Hillman.
Science (2006)

544 Citations

The lantibiotic nisin, a special case or not?

Eefjan Breukink;Ben de Kruijff.
Biochimica et Biophysica Acta (1999)

384 Citations

Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane.

Tamimount Mohammadi;Vincent van Dam;Robert Sijbrandi;Thierry Vernet.
The EMBO Journal (2011)

383 Citations

Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins

Athanasios Typas;Manuel Banzhaf;Bart van den Berg van Saparoea;Jolanda Verheul.
Cell (2010)

371 Citations

Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes.

Eefjan Breukink;Hester E. van Heusden;Pauline J. Vollmerhaus;Ewa Swiezewska.
Journal of Biological Chemistry (2003)

368 Citations

Assembly and stability of nisin-lipid II pores.

Hester Emilie Hasper;Ben de Kruijff;Eefjan Breukink.
Biochemistry (2004)

321 Citations

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