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Dirk T. S. Rijkers

Dirk T. S. Rijkers

D-Index & Metrics

Chemistry

D-Index
50
Citations
8007
World Ranking
14496
National Ranking
263

Overview

Dirk T. S. Rijkers is affiliated with Utrecht University in the Netherlands. Their research focuses on several interrelated fields and topics within organic chemistry, molecular biology, oncology, environmental chemistry, and pharmaceutical science.

The scientist's recent published papers highlight a broad engagement with chemical synthesis, toxicological studies, and the application of transcriptomics in risk assessment. Notable publications include:

  • "Synthesis of a tricyclic hexapeptide -via two consecutive ruthenium-catalyzed macrocyclization steps- with a constrained topology to mimic vancomycin's binding properties toward D-Ala-D-Ala dipeptide" (2022, Bioorganic & Medicinal Chemistry Letters)
  • "Study on the effects of 19 perfluoroalkyl substances on gene expression and biokinetics of PFOS and PFOA in human HepaRG liver cells" (2021, Toxicology Letters)
  • "P19-58 Use of transcriptomic signatures of pesticide active substances in human kidney cells to support definition of cumulative assessment groups (CAGs) for risk assessment" (2024, Toxicology Letters)

Their collaboration network includes frequent coauthors such as Xin Yang, Johan Kemmink, Rob M. J. Liskamp, Styliani Fragki, and Aafke W. F. Janssen.

Dirk T. S. Rijkers has contributed to research in several main topics, including:

  • Click Chemistry and Applications
  • Chemical Synthesis and Analysis
  • Peptidase Inhibition and Analysis
  • Per- and polyfluoroalkyl substances research
  • Fluorine in Organic Chemistry

Publication venues frequently featuring their work include Toxicology Letters and Bioorganic & Medicinal Chemistry Letters.

Subfields addressed in their research span:

  • Organic Chemistry
  • Molecular Biology
  • Oncology
  • Environmental Chemistry
  • Pharmaceutical Science

Best Publications

  • Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry

    Fan Liu;Dirk T S Rijkers;Harm Post;Albert J R Heck

  • New insights into the hydrolytic degradation of poly(lactic acid): participation of the alcohol terminus

    S.J de Jong;E.R Arias;D.T.S Rijkers;C.F van Nostrum

  • Synthesis and applications of biomedical and pharmaceutical polymers via click chemistry methodologies

    Maarten van Dijk;Dirk T. S. Rijkers;Rob M. J. Liskamp;Cornelus F. van Nostrum

  • An electrostatic/hydrogen bond switch as the basis for the specific interaction of phosphatidic acid with proteins.

    Edgar E. Kooijman;D. Peter Tieleman;Christa Testerink;Teun Munnik

  • Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes

    Ingrid Dijkgraaf;Ingrid Dijkgraaf;Anneloes Y. Rijnders;Annemieke Soede;Annemarie C. Dechesne

  • Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics.

    Rob M. J. Liskamp;Dirk T. S. Rijkers;John A. W. Kruijtzer;Johan Kemmink

  • Tilt Angles of Transmembrane Model Peptides in Oriented and Non-Oriented Lipid Bilayers as Determined by 2H Solid-State NMR

    Erik Strandberg;Suat Özdirekcan;Dirk T.S. Rijkers;Patrick C.A. van der Wel

  • Islet amyloid polypeptide inserts into phospholipid monolayers as monomer.

    Maarten F.M. Engel;HaciAli Yigittop;Ronald C. Elgersma;Dirk T.S. Rijkers

  • The routine determination of the endogenous thrombin potential, first results in different forms of hyper- and hypocoagulability.

    S. Wielders;M. Mukherjee;J. Michiels;D. T. S. Rijkers

  • Phospholipid flop induced by transmembrane peptides in model membranes is modulated by lipid composition.

    Matthijs A. Kol;Adrianus N. C. van Laak;Dirk T. S. Rijkers;J. Antoinette Killian

  • Synthesis and characterization of enzymatically biodegradable PEG and peptide-based hydrogels prepared by click chemistry.

    Maarten van Dijk;Cornelus F van Nostrum;Wim E Hennink;Dirk T S Rijkers

  • Self-association of transmembrane alpha-helices in model membranes: importance of helix orientation and role of hydrophobic mismatch.

    Emma Sparr;Walter L. Ash;Petr V. Nazarov;Dirk T.S. Rijkers

  • Lipid dependence of membrane anchoring properties and snorkeling behavior of aromatic and charged residues in transmembrane peptides

    Erik Strandberg;Sven Morein;Dirk T. S. Rijkers;Rob M. J. Liskamp

  • The Effects of Hydrophobic Mismatch between Phosphatidylcholine Bilayers and Transmembrane Alpha-Helical Peptides Depend on the Nature of Interfacially Exposed Aromatic and Charged Residues

    M.R.R. de Planque;J.W.P. Boots;D.T.S. Rijkers;R.M.J. Liskamp

  • Influence of flanking residues on tilt and rotation angles of transmembrane peptides in lipid bilayers. A solid-state 2H NMR study.

    S. Özdirekcan;D.T.S. Rijkers;R.M.J. Liskamp;J.A. Killian

  • Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry

    Dirk T. S. Rijkers;G. Wilma van Esse;Remco Merkx;Arwin J. Brouwer

  • Factors Affecting Gas-Phase Deuterium Scrambling in Peptide Ions and Their Implications for Protein Structure Determination

    Jeroen A. A. Demmers;Dirk T. S. Rijkers;Johan Haverkamp;and J. Antoinette Killian

  • Highly efficient coupling of beta-substituted aminoethane sulfonyl azides with thio acids, toward a new chemical ligation reaction.

    Remco Merkx;Arwin J Brouwer;Dirk T S Rijkers;Rob M J Liskamp

  • Photocrosslinking and Click Chemistry Enable the Specific Detection of Proteins Interacting with Phospholipids at the Membrane Interface

    Jacob Gubbens;Eelco Ruijter;Laurence E.V. de Fays;J. Mirjam A. Damen

  • Synthesis of DOTA-conjugated multimeric [Tyr3]octreotide peptides via a combination of Cu(I)-catalyzed "click" cycloaddition and thio acid/sulfonyl azide "sulfo-click" amidation and their in vivo evaluation.

    Cheng-Bin Yim;Ingrid Dijkgraaf;Remco Merkx;Cees Versluis

Frequent Co-Authors

Rob M. J. Liskamp
Rob M. J. Liskamp University of Glasgow
J. Antoinette Killian
J. Antoinette Killian Utrecht University
Wim E. Hennink
Wim E. Hennink Utrecht University
Cornelus F. van Nostrum
Cornelus F. van Nostrum Utrecht University
Eefjan Breukink
Eefjan Breukink Utrecht University
Tina Vermonden
Tina Vermonden Utrecht University
Frances Separovic
Frances Separovic University of Melbourne
Roland J. Pieters
Roland J. Pieters Utrecht University
Eelco Ruijter
Eelco Ruijter Vrije Universiteit Amsterdam
Anthony Watts
Anthony Watts University of Oxford

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