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Biology and Biochemistry

D-Index
79
Citations
24556
World Ranking
4267
National Ranking
101

Overview

Frans B. L. Hogervorst is affiliated with the Antoni van Leeuwenhoek Hospital in the Netherlands. Their research primarily lies at the intersection of biochemistry, genetics, and molecular biology, with a strong emphasis on genetics.

Their work spans various subfields including genetics, molecular biology, pathology and forensic medicine, cancer research, and oncology. Key topics of focus include BRCA gene mutations in cancer, genomics and rare diseases, genetic associations and epidemiology, genetic factors in colorectal cancer, cancer genomics and diagnostics, DNA repair mechanisms, and genomic variations and chromosomal abnormalities.

Notable recent publications by Frans B. L. Hogervorst include:

  • Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women, 2021, New England Journal of Medicine
  • A high proportion of novel mutations in BRCA1 with strong founder effects among Dutch and Belgian hereditary breast and ovarian cancer families, 2020, PubMed
  • Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants, 2020, JAMA Oncology
  • Breast cancer risks associated with missense variants in breast cancer susceptibility genes, 2022, Genome Medicine
  • BRCAness digitalMLPA profiling predicts benefit of intensified platinum-based chemotherapy in triple-negative and luminal-type breast cancer, 2020, Breast Cancer Research

Frans B. L. Hogervorst has collaborated extensively with several frequent co-authors, including:

  • Anna Jakubowska
  • Gord Glendon
  • Irene L. Andrulis
  • D. Gareth Evans
  • Manjeet K. Bolla

Their work has appeared in various publication venues such as UNC Libraries, bioRxiv (Cold Spring Harbor Laboratory), New England Journal of Medicine, JAMA Oncology, and Genome Medicine.

Best Publications

  • Sequence variant classification and reporting: recommendations for improving the interpretation of cancer susceptibility genetic test results

    Sharon E. Plon;Diana M. Eccles;Douglas Easton;William D. Foulkes

  • Laminin receptor on platelets is the integrin VLA-6.

    Arnoud Sonnenberg;Piet W. Modderman;Frans Hogervorst

  • Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women

    Leila Dorling;Sara Carvalho;Jamie Allen

  • Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

    Nasim Mavaddat;Daniel Barrowdale;Irene L. Andrulis;Susan M. Domchek

  • A common coding variant in CASP8 is associated with breast cancer risk

    Angela Cox;Alison M. Dunning;Montserrat Garcia-Closas;Sabapathy Balasubramanian

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • MicroRNA related polymorphisms and breast cancer risk

    Sofia Khan;Dario Greco;Dario Greco;Kyriaki Michailidou;Roger L. Milne;Roger L. Milne

  • Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

    Timothy R. Rebbeck;Nandita Mitra;Fei Wan;Olga M. Sinilnikova

  • BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients

    A. Petrij-Bosch;T. Peelen;M. Van Vliet;R. Van Eijk

  • Cancer risks in BRCA2 families: estimates for sites other than breast and ovary

    C J van Asperen;R M Brohet;E J Meijers-Heijboer;N Hoogerbrugge

  • Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

    Bryony A Thompson;Bryony A Thompson;Amanda B Spurdle;John-Paul Plazzer;Marc S Greenblatt

  • The α6β4 Integrin Is a Receptor for both Laminin and Kalinin

    C.M. Niessen;F. Hogervorst;L.H. Jaspars;A.A. de Melker

  • Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

    Catherine M Phelan;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Jonathan P Tyrer;Siddhartha P Kar

  • Rapid detection of BRCA1 mutations by the protein truncation test

    Fbl Hogervorst;RS Cornelis;M Bout;M van Vliet

  • A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody.

    A. Sonnenberg;H. Janssen;F. Hogervorst;J. Calafat

  • Large genomic deletions and duplications in the BRCA1 gene identified by a novel quantitative method

    Frans B. L. Hogervorst;Petra M. Nederlof;Johan J. P. Gille;Cathal J. McElgunn

  • A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population

    Antonis C. Antoniou;Xianshu Wang;Zachary S. Fredericksen;Lesley McGuffog

  • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

    Roger L Milne;Roger L Milne;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Kyriaki Michailidou;Kyriaki Michailidou;Jonathan Beesley

  • Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

    Fergus J. Couch;Xianshu Wang;Lesley McGuffog;Andrew Lee

  • BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients (vol 17, pg 341, 1997)

    A. Petrij-Bosch;T. Peelen;M. van Vliet;R. van Eijk

Frequent Co-Authors

Irene L. Andrulis
Irene L. Andrulis University of Toronto
Fergus J. Couch
Fergus J. Couch Mayo Clinic
Douglas F. Easton
Douglas F. Easton University of Cambridge
Georgia Chenevix-Trench
Georgia Chenevix-Trench QIMR Berghofer Medical Research Institute
Heli Nevanlinna
Heli Nevanlinna University of Helsinki
Graham G. Giles
Graham G. Giles University of Melbourne
Melissa C. Southey
Melissa C. Southey Monash University
Paolo Radice
Paolo Radice Fondazione IRCCS Istituto Nazionale dei Tumori
Javier Benitez
Javier Benitez Instituto de Salud Carlos III
Peter Devilee
Peter Devilee Leiden University Medical Center

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