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Myriam Alcalay

Myriam Alcalay

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
12511
World Ranking
17880
National Ranking
570

Overview

Myriam Alcalay is affiliated with the University of Milan in Italy and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their research spans several subfields including Molecular Biology, Hematology, Genetics, Cancer Research, and Oncology.

Their scientific output reflects a focused interest in topics such as Acute Myeloid Leukemia Research, Epigenetics and DNA Methylation, Cancer Genomics and Diagnostics, Histone Deacetylase Inhibitors Research, PARP inhibition in cancer therapy, and Ovarian cancer diagnosis and treatment. In addition, they have worked within Biomedical and Engineering Education.

Major recent papers authored or co-authored by Myriam Alcalay include:

  • HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia (2020) published in Frontiers in Cell and Developmental Biology
  • Dual targeting of the DNA damage response pathway and BCL-2 in diffuse large B-cell lymphoma (2021) published in Leukemia
  • Has Drug Repurposing Fulfilled Its Promise in Acute Myeloid Leukaemia? (2020) published in Journal of Clinical Medicine
  • Hematological disorders after salvage PARPi treatment for ovarian cancer: Cytogenetic and molecular defects and clinical outcomes (2022) published in International Journal of Cancer
  • Acknowledging and citing core facilities (2022) published in EMBO Reports

Frequent co-authors of Myriam Alcalay include Pier Giuseppe Pelicci, Francesco Bertolini, Chiara Ronchini, Corrado Tarella, and Alicja Gruszka. The scientist's work has been published in diverse journals, with recent publications appearing in Frontiers in Cell and Developmental Biology, Leukemia, Journal of Clinical Medicine, International Journal of Cancer, and EMBO Reports.

This research profile indicates a consistent engagement with hematological malignancies and cancer therapeutics, particularly in leukemia and ovarian cancer. Topics such as epigenetic regulation and DNA damage response pathways are central to their studies, linking basic molecular biology with potential clinical applications.

Best Publications

  • Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype

    Brunangelo Falini;Christina Mecucci;Enrico Tiacci;Myriam Alcalay

  • The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

    Francesco Grignani;Pier Francesco Ferrucci;Ugo Testa;Giampaolo Talamo

  • Acute promyelocytic leukemia: from genetics to treatment.

    F Grignani;M Fagioli;M Alcalay;L Longo

  • A PMLRARα transgene initiates murine acute promyelocytic leukemia

    Diane Brown;Scott Kogan;Eric Lagasse;Irving Weissman

  • Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance.

    Myriam Alcalay;Enrico Tiacci;Roberta Bergomas;Barbara Bigerna

  • Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties.

    P P Pandolfi;F Grignani;M Alcalay;A Mencarelli

  • Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.

    P.P. Pandolfi;M. Alcalay;M. Fagioli;D. Zangrilli

  • Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

    Andrea Viale;Francesca De Franco;Francesca De Franco;Annette Orleth;Annette Orleth;Valeria Cambiaghi

  • Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.

    M Alcalay;D Zangrilli;P P Pandolfi;L Longo

  • Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair

    Myriam Alcalay;Natalia Meani;Vania Gelmetti;Anna Fantozzi

  • Role for histone deacetylase 1 in human tumor cell proliferation

    Silvia Senese;Katrin Zaragoza;Simone Minardi;Ivan Muradore

  • Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases.

    E Colombo;E Colombo;M Alcalay;M Alcalay;P G Pelicci;P G Pelicci

  • The Promyelocytic Leukemia Gene Product (PML) Forms Stable Complexes with the Retinoblastoma Protein

    Myriam Alcalay;Lucia Tomassoni;Emanuela Colombo;Stephan Stoldt

  • Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.

    L Longo;P P Pandolfi;A Biondi;A Rambaldi

  • Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia

    Brunangelo Falini;Maria Paola Martelli;Niccolò Bolli;Rossella Bonasso

  • Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.

    Fagioli M;Alcalay M;Pandolfi Pp;Venturini L

  • Molecular monitoring of the myl/retinoic acid receptor-alpha fusion gene in acute promyelocytic leukemia by polymerase chain reaction

    A Biondi;A Rambaldi;PP Pandolfi;V Rossi

  • Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant.

    Emanuela Colombo;Paola Martinelli;Raffaella Zamponi;Danielle C. Shing

  • Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.

    M Alcalay;D Zangrilli;M Fagioli;P P Pandolfi

  • Family expansion and gene rearrangements contributed to the functional specialization of PRDM genes in vertebrates

    Irene Fumasoni;Natalia Meani;Davide Rambaldi;Gaia Scafetta

Frequent Co-Authors

Pier Giuseppe Pelicci
Pier Giuseppe Pelicci European Institute of Oncology
Andrea Biondi
Andrea Biondi University of Milano-Bicocca
Cesare Peschle
Cesare Peschle Istituto Superiore di Sanità
Francesco Lo-Coco
Francesco Lo-Coco University of Rome Tor Vergata
Ugo Testa
Ugo Testa Istituto Superiore di Sanità
Alessandro Rambaldi
Alessandro Rambaldi University of Milan
Giuseppe Viale
Giuseppe Viale University of Milan
Franco Mandelli
Franco Mandelli Sapienza University of Rome
Saverio Minucci
Saverio Minucci European Institute of Oncology
Elisabetta Dejana
Elisabetta Dejana Uppsala University

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