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Christine Chomienne

Christine Chomienne

D-Index & Metrics

Biology and Biochemistry

D-Index
85
Citations
31512
World Ranking
3104
National Ranking
72

Medicine

D-Index
85
Citations
31929
World Ranking
14464
National Ranking
465

Overview

Christine Chomienne is affiliated with Université Paris Cité in France. Their research primarily focuses on medicine, with a significant emphasis on biochemistry, genetics, and molecular biology. Within these broader fields, their work extensively covers subfields such as hematology, genetics, molecular biology, rheumatology, and immunology.

Their academic contributions include notable recent papers spanning topics related to leukemia, myeloproliferative neoplasms, and immune cell regulation. Key publications include:

  • Etoposide, an anticancer drug involved in therapy-related secondary leukemia: Enzymes at play (2021), published in Translational Oncology
  • Interferon-Alpha (IFN) Therapy Discontinuation Is Feasible in Myeloproliferative Neoplasm (MPN) Patients with Complete Hematological Remission (2020), published in Blood
  • BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome (2021), published in International Journal of Molecular Sciences
  • Human CREBBP acetyltransferase is impaired by etoposide quinone, an oxidative and leukemogenic metabolite of the anticancer drug etoposide through modification of redox-sensitive zinc-finger cysteine residues (2020), published in Free Radical Biology and Medicine
  • PLZF Acetylation Levels Regulate NKT Cell Differentiation (2021), published in The Journal of Immunology

The scientist has contributed frequently to certain journals, with multiple publications in Blood, and singular contributions to Translational Oncology, International Journal of Molecular Sciences, The Journal of Immunology, and Free Radical Biology and Medicine.

Research coauthors who have frequently collaborated with Christine Chomienne include Bruno Cassinat, Fabien Guidez, Nabih Maslah, Jean-Jacques Kiladjian, and Panhong Gou.

The main topics of their research are:

  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Acute Myeloid Leukemia Research
  • Eosinophilic Disorders and Syndromes
  • Chronic Myeloid Leukemia Treatments
  • Immune Cell Function and Interaction
  • Hemoglobinopathies and Related Disorders
  • Retinoids in leukemia and cellular processes

Christine Chomienne's work covers a wide spectrum of hematologic disorders and molecular mechanisms involved in cancer biology and immune regulation.

Best Publications

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

    Catherine Lavau;Agnès Marchio;Christine Chomienne

  • The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus

    Christine Chomienne;Michel Lanotte;Laurent Degos

  • All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results.

    Sylvie Castaigne;Christine Chomienne;Marie Therese Daniel;Paola Ballerini

  • Patterns of somatic structural variation in human cancer genomes

    Yilong Li;Nicola D Roberts;Jeremiah A Wala;Jeremiah A Wala;Ofer Shapira;Ofer Shapira

  • Cancer stem cell definitions and terminology: the devil is in the details

    Peter Valent;Dominique Bonnet;Ruggero De Maria;Tsvee Lapidot

  • Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera

    Jean-Jacques Kiladjian;Bruno Cassinat;Sylvie Chevret;Pascal Turlure

  • Effect of all transretinoic acid in newly diagnosed acute promyelocytic leukemia. Results of a multicenter randomized trial. European APL 91 Group

    P Fenaux;MC Le Deley;S Castaigne;E Archimbaud

  • The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion.

    M.H. Koken;F. Puvion-Dutilleul;M.C. Guillemin;A. Viron

  • All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship

    Christine Chomienne;Paola Ballerini;Nicole Balitrand;Marie Therese Daniel

  • All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia.

    L Degos;H Dombret;C Chomienne;M T Daniel

  • Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).

    Jonathan D. Licht;Christine Chomienne;Andre Goy;Alex Chen

  • Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL

    Lucia Altucci;Lucia Altucci;Aurelie Rossin;Wolfgang Raffelsberger;Armin Reitmair

  • Incidence, Clinical Features, and Outcome of AllTrans-Retinoic Acid Syndrome in 413 Cases of Newly Diagnosed Acute Promyelocytic Leukemia

    S. De Botton;H. Dombret;M. Sanz;J. San Miguel

  • Analysis of risk factors for myelodysplasias, leukemias and death from infection among patients with congenital neutropenia. Experience of the French Severe Chronic Neutropenia Study Group.

    Jean Donadieu;Thierry Leblanc;Brigitte Bader Meunier;Mohamed Barkaoui

  • DNA Topoisomerase II in Therapy-Related Acute Promyelocytic Leukemia

    Anita R. Mistry;Carolyn A. Felix;Ryan J. Whitmarsh;Annabel Mason

  • All-transretinoic acid followed by intensive chemotherapy gives a high complete remission rate and may prolong remissions in newly diagnosed acute promyelocytic leukemia: a pilot study on 26 cases.

    P Fenaux;S Castaigne;H Dombret;E Archimbaud

  • Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists.

    Stéphane Prost;Francis Relouzat;Marc Spentchian;Yasmine Ouzegdouh

  • High molecular response rate of polycythemia vera patients treated with pegylated interferon alpha-2a.

    Jean-Jacques Kiladjian;Bruno Cassinat;Pascal Turlure;Nathalie Cambier

  • Health, economic, and quality-of-life effects of erythropoietin and granulocyte colony-stimulating factor for the treatment of myelodysplastic syndromes: a randomized, controlled trial.

    Nicole Casadevall;Pierre Durieux;Stéphanie Dubois;François Hemery

Frequent Co-Authors

Bruno Cassinat
Bruno Cassinat Université Paris Cité
Pierre Fenaux
Pierre Fenaux Université Paris Cité
Sylvie Castaigne
Sylvie Castaigne Versailles Saint-Quentin-en-Yvelines University
Hervé Dombret
Hervé Dombret Université Paris Cité
Emmanuel Raffoux
Emmanuel Raffoux Hôpital Saint-Louis
Jérôme Larghero
Jérôme Larghero Université Paris Cité
Sylvie Chevret
Sylvie Chevret Université Paris Cité
Anne Janin
Anne Janin Université Paris Cité
Dominique Charron
Dominique Charron Grenoble Alpes University
Miguel A. Sanz
Miguel A. Sanz University of Valencia

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