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Jérôme Larghero

Jérôme Larghero

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
16586
World Ranking
8620
National Ranking
298

Overview

Jérôme Larghero is affiliated with Université Paris Cité in France and has contributed extensively to the field of Medicine, with a particular focus on Surgery, Molecular Biology, Oncology, Biomedical Engineering, and Genetics. Their research interests encompass several specialized topics including CAR-T cell therapy research, Tissue Engineering and Regenerative Medicine, 3D Printing in Biomedical Research, Mesenchymal stem cell research, Hematopoietic Stem Cell Transplantation, Spinal Dysraphism and Malformations, and Electrospun Nanofibers in Biomedical Applications.

Larghero's recent publications demonstrate ongoing contributions to advanced cellular therapies and regenerative medicine. Notable papers include:

  • Human umbilical cord-derived mesenchymal stem/stromal cells: a promising candidate for the development of advanced therapy medicinal products (2021, Stem Cell Research & Therapy)
  • Determinants of CD19-positive vs CD19-negative relapse after tisagenlecleucel for B-cell acute lymphoblastic leukemia (2021, Leukemia)
  • Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial (2022, Critical Care)
  • UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial (2022, The Lancet Haematology)
  • Development of extracellular vesicle-based medicinal products: A position paper of the group "Extracellular Vesicle translatiOn to clinicaL perspectiVEs - EVOLVE France" (2021, Advanced Drug Delivery Reviews)

Larghero frequently publishes in several scientific journals, including:

  • Bone Marrow Transplantation
  • Stem Cell Research & Therapy
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • Blood

Collaboration is a significant aspect of their research, with frequent co-authors including:

  • Lionel Faivre
  • Miryam Mebarki
  • Audrey Cras
  • Isabelle Madelaine
  • Lousineh Arakélian

Best Publications

  • Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

    Marina Cavazzana-Calvo;Emmanuel Payen;Olivier Negre;Gary Wang

  • The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) Trial: First Randomized Placebo-Controlled Study of Myoblast Transplantation

    Philippe Menasché;Ottavio Alfieri;Stefan Janssens;William McKenna

  • Autologous Hematopoietic Stem Cell Transplantation vs Intravenous Pulse Cyclophosphamide in Diffuse Cutaneous Systemic Sclerosis: A Randomized Clinical Trial

    J.M. van Laar;D. Farge;J.K. Sont;K. Naraghi

  • Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report

    Philippe Menasché;Philippe Menasché;Valérie Vanneaux;Albert Hagège;Albert Hagège;Alain Bel

  • Transplantation of Human Embryonic Stem Cell–Derived Cardiovascular Progenitors for Severe Ischemic Left Ventricular Dysfunction

    Philippe Menasché;Valérie Vanneaux;Albert Hagège;Alain Bel

  • Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells.

    Raphael Ceccaldi;Raphael Ceccaldi;Kalindi Parmar;Enguerran Mouly;Marc Delord

  • Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies.

    Reuben Benjamin;Reuben Benjamin;Charlotte Graham;Charlotte Graham;Deborah Yallop;Agnieszka Jozwik;Agnieszka Jozwik

  • Arsenic Trioxide and Melarsoprol Induce Apoptosis in Plasma Cell Lines and in Plasma Cells from Myeloma Patients

    Philippe Rousselot;Sylvaine Labaume;Jean-Pierre Marolleau;Jérôme Larghero

  • Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling

    Larissa Lordier;Larissa Lordier;Larissa Lordier;Abdelali Jalil;Fréderic Aurade;Fréderic Larbret;Fréderic Larbret

  • Phenotypic and functional characterization of bone marrow mesenchymal stem cells derived from patients with multiple myeloma.

    B Arnulf;S Lecourt;J Soulier;B Ternaux

  • Proplatelet formation is regulated by the Rho/ROCK pathway

    Yunhua Chang;Yunhua Chang;Frédéric Auradé;Frédéric Auradé;Frédéric Larbret;Yanyan Zhang;Yanyan Zhang

  • Comparison of human skeletal myoblasts and bone marrow-derived CD133+progenitors for the repair of infarcted myocardium

    Onnik Agbulut;Susanne Vandervelde;Nawwar Al Attar;Jérôme Larghero

  • Long-term follow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosis

    M C Vonk;Z Marjanovic;F H J van den Hoogen;S Zohar

  • Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes.

    L. Vija;D. Farge;J.-F. Gautier;P. Vexiau

  • Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

    Elodie Pronier;Elodie Pronier;Carole Almire;Hayat Mokrani;Hayat Mokrani;Aparna Vasanthakumar

  • Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions

    Samuel Quentin;Wendy Cuccuini;Raphael Ceccaldi;Olivier Nibourel

  • Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial

    Christopher J. Hawkey;Matthieu Allez;Miranda M. Clark;Myriam Labopin

  • Cardiovascular progenitor-derived extracellular vesicles recapitulate the beneficial effects of their parent cells in the treatment of chronic heart failure.

    Anaïs Kervadec;Anaïs Kervadec;Valérie Bellamy;Valérie Bellamy;Nadia El Harane;Nadia El Harane;Lousineh Arakélian

  • Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway

    Jean Soulier;Thierry Leblanc;Jérôme Larghero;Hélène Dastot

  • Towards a clinical use of human embryonic stem cell-derived cardiac progenitors: a translational experience

    Philippe Menasché;Philippe Menasché;Valérie Vanneaux;Jean-Roch Fabreguettes;Alain Bel

Frequent Co-Authors

Gérard Socié
Gérard Socié Université Paris Cité
Philippe Menasché
Philippe Menasché Université Paris Cité
Eliane Gluckman
Eliane Gluckman Université Paris Cité
Christine Chomienne
Christine Chomienne Université Paris Cité
Vanderson Rocha
Vanderson Rocha Universidade de São Paulo
Raphaël Porcher
Raphaël Porcher Université Paris Cité
Patrick Bruneval
Patrick Bruneval Grenoble Alpes University
William Vainchenker
William Vainchenker Institut Gustave Roussy
Jean Soulier
Jean Soulier Hôpital Saint-Louis
André Baruchel
André Baruchel Hôpital Robert-Debré

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