His primary scientific interests are in Cell biology, Megakaryocyte, Molecular biology, Immunology and Progenitor cell. His research in Cell biology is mostly concerned with Signal transduction. Najet Debili studied Megakaryocyte and Platelet that intersect with Immunogold labelling, Immunoelectron microscopy, Cancer research and Fibrinogen.
His Molecular biology research is multidisciplinary, relying on both Cell culture, Receptor and Gene expression, In situ hybridization. His research integrates issues of Wiskott–Aldrich syndrome protein, Cdc42 GTP-Binding Protein and Thrombopoiesis in his study of Immunology. His Progenitor cell research is multidisciplinary, incorporating elements of CD34, Haematopoiesis, Cellular differentiation and Polycythemia vera.
Cell biology, Megakaryocyte, Molecular biology, Haematopoiesis and Immunology are his primary areas of study. Najet Debili interconnects Actin cytoskeleton, Cytoskeleton and Cellular differentiation in the investigation of issues within Cell biology. Najet Debili has included themes like Platelet, Internal medicine and Thrombopoietin in his Megakaryocyte study.
His work carried out in the field of Molecular biology brings together such families of science as Cancer research, Gene expression, Mutation, Receptor and RUNX1. His Haematopoiesis study incorporates themes from Progenitor cell, Embryonic stem cell and Cytokine. His work in the fields of Immunology, such as Bone marrow, overlaps with other areas such as Interleukin 3.
His primary areas of investigation include Cell biology, Molecular biology, RHOA, Megakaryocyte and Cancer research. His studies in Cell biology integrate themes in fields like Gene knockdown, Cytoskeleton and Dynamin. His Molecular biology study integrates concerns from other disciplines, such as Mutation, Thrombopoietin receptor, Haematopoiesis and Calreticulin.
His RHOA study combines topics in areas such as Protein tyrosine phosphatase, Protein kinase A, Phosphorylation, CDC42 and Actin cytoskeleton. The study incorporates disciplines such as Thrombopoietin, Immunology and Polyploid in addition to Megakaryocyte. His study in Cancer research is interdisciplinary in nature, drawing from both Leukemia and RUNX1.
Najet Debili mostly deals with Molecular biology, Mutation, Cancer research, Leukemia and RUNX1. His Molecular biology study combines topics from a wide range of disciplines, such as Missense mutation, Induced pluripotent stem cell, Essential thrombocythemia, Thrombopoietin and Cytoskeleton organization. In general Induced pluripotent stem cell, his work in Human embryonic stem cell line is often linked to Dominant-Negative Mutation linking many areas of study.
His Essential thrombocythemia research is classified as research in Immunology. His Thrombopoietin research integrates issues from FLI1, Transcription factor, Friend leukemia and MAPK/ERK pathway. Najet Debili combines subjects such as Exome sequencing, Germline mutation, Filamin, Thrombocytopathy and Platelet activation with his study of Cytoskeleton organization.
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c-Mpl ligand is a humoral regulator of megakaryocytopoiesis
Françoise Wendling;Eugene Maraskovsky;Najet Debili;Christina Florindo.
AIF deficiency compromises oxidative phosphorylation
Nicola Vahsen;Céline Candé;Jean Jacques Brière;Paule Bénit.
The EMBO Journal (2004)
The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors.
Najet Debili;Françoise Wendling;Andre Katz;Josette Guichard.
The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets.
N Debili;F Wendling;D Cosman;M Titeux.
Platelet formation is the consequence of caspase activation within megakaryocytes
Stephane de Botton;Siham Sabri;Eric Daugas;Yael Zermati.
Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome
Cornelis A. Albers;Cornelis A. Albers;Cornelis A. Albers;Dirk S. Paul;Harald Schulze;Kathleen Freson.
Nature Genetics (2012)
Characterization of a bipotent erythro-megakaryocytic progenitor in human bone marrow.
Najet Debili;Laure Coulombel;Laure Croisille;André Katz.
Multivesicular Bodies Are an Intermediate Stage in the Formation of Platelet α-Granules
Harry F.G. Heijnen;Najet Debili;William Vainchencker;Janine Breton-Gorius.
Effects of the recombinant hematopoietic growth factors interleukin-3, interleukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells.
Najet Debili;Jean-Marc Massé;André Katz;Josette Guichard.
Hematopoietic growth factors and human megakaryocyte differentiation.
Debili N;Breton-Gorius J;Vainchenker W.
Bone Marrow Transplantation (1992)
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