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Biology and Biochemistry
France
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
15422
World Ranking
6428
National Ranking
189

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in France Leader Award

Overview

Najet Debili is affiliated with the Institut Gustave Roussy in France and has made contributions primarily in the field of Medicine, with a strong focus on Hematology. Their research intersects several specialized subfields including Genetics, Cancer Research, Molecular Biology, and Pathology and Forensic Medicine.

Their publication record includes work on topics such as Myeloproliferative Neoplasms: Diagnosis and Treatment, Acute Myeloid Leukemia Research, Chronic Myeloid Leukemia Treatments, Platelet Disorders and Treatments, Kruppel-like factors research, Lymphoma Diagnosis and Treatment, and Pancreatic and Hepatic Oncology Research.

Najet Debili's recent papers include:

  • "Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model" (2022), Journal of Clinical Investigation
  • "Role of Rho-GTPases in megakaryopoiesis" (2021), Small GTPases
  • "Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms" (2020), Oncogene
  • "Dual role of EZH2 in megakaryocyte differentiation" (2021), Blood
  • "ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis" (2023), Haematologica

These publications have appeared most frequently in the journals Blood, Journal of Clinical Investigation, Small GTPases, Haematologica, and Oncogene.

Najet Debili often collaborates with several researchers, including Hana Raslová, William Vainchenker, Isabelle Plo, Brahim Arkoun, and Iléana Antony-Debré.

Best Publications

  • c-Mpl ligand is a humoral regulator of megakaryocytopoiesis

    Françoise Wendling;Eugene Maraskovsky;Najet Debili;Christina Florindo

  • AIF deficiency compromises oxidative phosphorylation

    Nicola Vahsen;Céline Candé;Jean Jacques Brière;Paule Bénit

  • Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome

    Cornelis A. Albers;Cornelis A. Albers;Cornelis A. Albers;Dirk S. Paul;Harald Schulze;Kathleen Freson

  • Platelet formation is the consequence of caspase activation within megakaryocytes

    Stephane de Botton;Siham Sabri;Eric Daugas;Yael Zermati

  • The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets.

    N Debili;F Wendling;D Cosman;M Titeux

  • The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors.

    Najet Debili;Françoise Wendling;Andre Katz;Josette Guichard

  • Characterization of a bipotent erythro-megakaryocytic progenitor in human bone marrow.

    Najet Debili;Laure Coulombel;Laure Croisille;André Katz

  • Multivesicular Bodies Are an Intermediate Stage in the Formation of Platelet α-Granules

    Harry F.G. Heijnen;Najet Debili;William Vainchencker;Janine Breton-Gorius

  • Effects of the recombinant hematopoietic growth factors interleukin-3, interleukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells.

    Najet Debili;Jean-Marc Massé;André Katz;Josette Guichard

  • Uptake of plasma fibrinogen into the alpha granules of human megakaryocytes and platelets

    P Harrison;B Wilbourn;N Debili;W Vainchenker

  • Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand

    Elisabeth M. Cramer;Françoise Norol;Françoise Norol;Josette Guichard;Josette Guichard;Janine Breton-Gorius;Janine Breton-Gorius

  • Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling

    Larissa Lordier;Larissa Lordier;Larissa Lordier;Abdelali Jalil;Fréderic Aurade;Fréderic Larbret;Fréderic Larbret

  • Endomitosis of Human Megakaryocytes Are Due to Abortive Mitosis

    Natacha Vitrat;Karine Cohen-Solal;Claudine Pique;Jean Pierre LeCouedic

  • Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera.

    Valérie Ugo;Christophe Marzac;Irène Teyssandier;Frédéric Larbret

  • Proplatelet formation is regulated by the Rho/ROCK pathway

    Yunhua Chang;Yunhua Chang;Frédéric Auradé;Frédéric Auradé;Frédéric Larbret;Yanyan Zhang;Yanyan Zhang

  • The interaction between Cdc42 and WASP is required for SDF-1–induced T-lymphocyte chemotaxis

    Elie Haddad;José L. Zugaza;Fawzia Louache;Najet Debili

  • Evidence that the JAK2 G1849T (V617F) mutation occurs in a lymphomyeloid progenitor in polycythemia vera and idiopathic myelofibrosis.

    Francois Delhommeau;Francois Delhommeau;Sabrina Dupont;Carole Tonetti;Aline Masse

  • Regulation of the expression of IL-6 in human monocytes.

    S Navarro;N Debili;J F Bernaudin;W Vainchenker

  • Expression of CD34 and platelet glycoproteins during human megakaryocytic differentiation.

    Najet Debili;Cherifa Issaad;Jean-Marc Massé;Josette Guichard

  • Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment.

    Siham Sabri;Adlen Foudi;Siham Boukour;Brigitte Franc

Frequent Co-Authors

William Vainchenker
William Vainchenker Institut Gustave Roussy
Isabelle Plo
Isabelle Plo University of Paris-Saclay
Eric Solary
Eric Solary Institut Gustave Roussy
Rémi Favier
Rémi Favier University of Paris-Saclay
Jean-Luc Villeval
Jean-Luc Villeval Institut Gustave Roussy
Willem H. Ouwehand
Willem H. Ouwehand University of Cambridge
Guido Kroemer
Guido Kroemer Université Paris Cité
Stefan N. Constantinescu
Stefan N. Constantinescu Ludwig Cancer Research
Alan T. Nurden
Alan T. Nurden Centre national de la recherche scientifique, CNRS
Jérôme Larghero
Jérôme Larghero Université Paris Cité

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