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Jean-Luc Villeval

Jean-Luc Villeval

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
15788
World Ranking
15941
National Ranking
654

Overview

Jean-Luc Villeval is affiliated with the Institut Gustave Roussy in France, focusing on medical research related to hematological disorders. Their work primarily spans the fields of medicine, with significant contributions in genetics, hematology, rheumatology, molecular biology, and neurology.

Their research topics cover several key areas including:

  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Eosinophilic Disorders and Syndromes
  • Chronic Myeloid Leukemia Treatments
  • Acute Myeloid Leukemia Research
  • Kruppel-like factors research
  • Extracellular vesicles in disease
  • Retinoids in leukemia and cellular processes

Jean-Luc Villeval has published numerous papers. Notable recent works include:

  • "Erythrocyte-derived microvesicles induce arterial spasms in JAK2V617F myeloproliferative neoplasm," 2020, Journal of Clinical Investigation
  • "Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms," 2021, Blood
  • "Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN," 2020, Nature Communications
  • "JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML," 2020, The Journal of Experimental Medicine
  • "SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice," 2023, Leukemia

Frequently publishing in established venues, their work appears notably in:

  • Blood (5 publications)
  • Journal of Clinical Investigation (2 publications)
  • Nature Communications (1 publication)
  • The Journal of Experimental Medicine (1 publication)
  • Leukemia (1 publication)

Collaboration is a significant aspect of their research, with frequent coauthors including:

  • Isabelle Plo (11 collaborations)
  • William Vainchenker (10 collaborations)
  • Valérie Edmond (10 collaborations)
  • Caroline Marty (8 collaborations)
  • Tracy Dagher (6 collaborations)

Best Publications

  • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

    Chloé James;Valérie Ugo;Jean-Pierre Le Couédic;Judith Staerk

  • A Serious Adverse Event after Successful Gene Therapy for X-Linked Severe Combined Immunodeficiency

    Salima Hacein-Bey-Abina;Christof Von Kalle;Manfred Schmidt;Françoise Le Deist

  • Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients

    Ulrich Dührsen;Jean-Luc Villeval;Janis Boyd;George Kannourakis

  • JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis

    Catherine Lacout;Didier F. Pisani;Didier F. Pisani;Micheline Tulliez;Micheline Tulliez;Françoise Moreau Gachelin;Françoise Moreau Gachelin

  • Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily.

    Martine Jandrot-Perrus;Martine Jandrot-Perrus;Martine Jandrot-Perrus;Samantha Busfield;Samantha Busfield;Samantha Busfield;Anne-Helène Lagrue;Anne-Helène Lagrue;Anne-Helène Lagrue;Ximing Xiong;Ximing Xiong;Ximing Xiong

  • High Thrombopoietin Production by Hematopoietic Cells Induces a Fatal Myeloproliferative Syndrome in Mice

    Jean-Luc Villeval;Karine Cohen-Solal;Karine Cohen-Solal;Micheline Tulliez;Micheline Tulliez;Stéphane Giraudier;Stéphane Giraudier

  • Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

    Annette Deichmann;Salima Hacein-Bey-Abina;Manfred Schmidt;Manfred Schmidt;Alexandrine Garrigue

  • Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis.

    Caroline Marty;Caroline Marty;Caroline Marty;Christian Pecquet;Christian Pecquet;Harini Nivarthi;Mira El-Khoury;Mira El-Khoury;Mira El-Khoury

  • Hematopoietic-specific β1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2

    Patrick Lecine;Joseph E. Italiano;Sang-We Kim;Jean-Luc Villeval

  • JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

    Isabelle Plo;Isabelle Plo;Mayuka Nakatake;Mayuka Nakatake;Laurent Malivert;Jean-Pierre de Villartay

  • A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression.

    C Marty;C Lacout;C Lacout;N Droin;N Droin;J-P Le Couédic;J-P Le Couédic

  • Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice.

    Caroline Marty;Catherine Lacout;Catherine Lacout;Catherine Lacout;Antoine Martin;Salma Hasan;Salma Hasan;Salma Hasan

  • Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold.

    Elisabeth Cramer;Katherine B. Pryzwansky;Jean-Luc Villeval;Ugo Testa

  • Activating mutations in human acute megakaryoblastic leukemia

    Sébastien Malinge;Sébastien Malinge;Christine Ragu;Christine Ragu;Veronique Della-Valle;Didier Pisani;Didier Pisani

  • Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia

    Sebastien Malinge;Raouf Ben-Abdelali;Catherine Settegrana;Isabelle Radford-Weiss;Isabelle Radford-Weiss

  • JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα

    Salma Hasan;Catherine Lacout;Caroline Marty;Marie Cuingnet

  • A monoclonal antibody against an erythrocyte ontogenic antigen identifies fetal and adult erythroid progenitors.

    P Edelman;G Vinci;JL Villeval;W Vainchenker

  • Aegyptin, a Novel Mosquito Salivary Gland Protein, Specifically Binds to Collagen and Prevents Its Interaction with Platelet Glycoprotein VI, Integrin α2β1, and von Willebrand Factor *

    Eric Calvo;Fuyuki Tokumasu;Osvaldo Marinotti;Jean Luc Villeval

  • Pathophysiology of Thrombocytopenia and Anemia in Mice Lacking Transcription Factor NF-E2

    Jack Levin;Jin-Peng Peng;Jin-Peng Peng;Jin-Peng Peng;Georgiann R. Baker;Georgiann R. Baker;Georgiann R. Baker;Jean-Luc Villeval;Jean-Luc Villeval;Jean-Luc Villeval

  • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

    Ugo;James C;Vainchenker W

Frequent Co-Authors

William Vainchenker
William Vainchenker Institut Gustave Roussy
Isabelle Plo
Isabelle Plo University of Paris-Saclay
Stefan N. Constantinescu
Stefan N. Constantinescu Ludwig Cancer Research
Najet Debili
Najet Debili Institut Gustave Roussy
Eric Solary
Eric Solary Institut Gustave Roussy
Bruno Cassinat
Bruno Cassinat Université Paris Cité
Alessandro M. Vannucchi
Alessandro M. Vannucchi University of Florence
Ugo Testa
Ugo Testa Istituto Superiore di Sanità
Florence Pasquier
Florence Pasquier University of Lille

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