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Neuroscience

D-Index
52
Citations
16971
World Ranking
5214
National Ranking
31

Overview

Hajime Hirase is affiliated with the University of Copenhagen in Denmark and has contributed extensively to the fields of neuroscience, biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on cellular and molecular neuroscience, molecular biology, neurology, cognitive neuroscience, and endocrine and autonomic systems.

The scientist's work covers several main topics including neuroscience and neuropharmacology research, traumatic brain injury and neurovascular disturbances, photoreceptor and optogenetics research, neural dynamics and brain function, neuroinflammation and neurodegeneration mechanisms, cerebrospinal fluid and hydrocephalus, and sleep and wakefulness research.

Frequent publication venues for Hajime Hirase include bioRxiv (Cold Spring Harbor Laboratory), Nature Neuroscience, Nature Communications, Science, and Scientific Reports.

Their recent papers include:

  • "Cerebrospinal fluid influx drives acute ischemic tissue swelling" (2020, Science)
  • "Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine" (2022, Nature Neuroscience)
  • "Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance" (2020, Nature Communications)
  • "Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema" (2023, Nature)
  • "Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep" (2025, Cell)

Hirase's frequent coauthors include:

  • Maiken Nedergaard
  • Ayumu Konno
  • Hirokazu Hirai
  • Celia Kjærby
  • Natalie Hauglund

The areas of study and topics indicate a strong emphasis on neural mechanisms underlying brain function and pathology, with particular interest in the role of neurotransmitters, cerebrospinal fluid dynamics, and sleep-related neural processes. Their contributions span experimental approaches addressing neurovascular and glymphatic systems as well as molecular signaling in neurology.

Best Publications

  • Accuracy of Tetrode Spike Separation as Determined by Simultaneous Intracellular and Extracellular Measurements

    Kenneth D. Harris;Darrell A. Henze;Jozsef Csicsvari;Hajime Hirase

  • Replay and Time Compression of Recurring Spike Sequences in the Hippocampus

    Zoltán Nádasdy;Hajime Hirase;András Czurkó;Jozsef Csicsvari

  • Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons in the Behaving Rat

    Jozsef Csicsvari;Hajime Hirase;András Czurkó;Akira Mamiya

  • Organization of cell assemblies in the hippocampus

    Kenneth D. Harris;Jozsef Csicsvari;Jozsef Csicsvari;Hajime Hirase;George Dragoi

  • Characterization of Neocortical Principal Cells and Interneurons by Network Interactions and Extracellular Features

    Peter Barthó;Hajime Hirase;Lenaïc Monconduit;Michael Zugaro

  • Reliability and State Dependence of Pyramidal Cell–Interneuron Synapses in the Hippocampus: an Ensemble Approach in the Behaving Rat

    Jozsef Csicsvari;Hajime Hirase;Andras Czurko;György Buzsáki

  • Aquaporin-4-dependent glymphatic solute transport in the rodent brain.

    Humberto Mestre;Lauren M. Hablitz;Anna L.R. Xavier;Weixi Feng

  • Ensemble Patterns of Hippocampal CA3-CA1 Neurons during Sharp Wave–Associated Population Events

    Jozsef Csicsvari;Hajime Hirase;Akira Mamiya;György Buzsáki

  • Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells.

    Kenneth D. Harris;Darrell A. Henze;Hajime Hirase;Xavier Leinekugel

  • Calcium dynamics of cortical astrocytic networks in vivo.

    Hajime Hirase;Lifen Qian;Peter Barthó;György Buzsáki

  • Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo

    Norio Takata;Tsuneko Mishima;Chihiro Hisatsune;Terumi Nagai

  • Temporal Interaction between Single Spikes and Complex Spike Bursts in Hippocampal Pyramidal Cells

    Kenneth D Harris;Hajime Hirase;Xavier Leinekugel;Darrell A Henze

  • Cerebrospinal fluid influx drives acute ischemic tissue swelling

    Humberto Mestre;Ting Du;Ting Du;Amanda M Sweeney;Guojun Liu;Guojun Liu

  • Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain.

    Hiromu Monai;Masamichi Ohkura;Mika Tanaka;Yuki Oe

  • Correlated bursts of activity in the neonatal hippocampus in vivo.

    Xavier Leinekugel;Rustem Khazipov;Rustem Khazipov;Robert Cannon;Hajime Hirase

  • Fast network oscillations in the hippocampal CA1 region of the behaving rat.

    Jozsef Csicsvari;Hajime Hirase;András Czurkó;Akira Mamiya

  • Sustained activation of hippocampal pyramidal cells by 'space clamping' in a running wheel.

    András Czurkó;Hajime Hirase;Jozsef Csicsvari;György Buzsáki

  • Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

    Unknown

  • A community-based transcriptomics classification and nomenclature of neocortical cell types

    Rafael Yuste;Michael Hawrylycz;Nadia Aalling;Argel Aguilar-Valles

  • Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors

    Yoshiaki Shinohara;Hajime Hirase;Masahiko Watanabe;Makoto Itakura

  • Multiphoton stimulation of neurons.

    Hajime Hirase;Volodymyr Nikolenko;Jesse H. Goldberg;Rafael Yuste

Frequent Co-Authors

György Buzsáki
György Buzsáki New York University
Jozsef Csicsvari
Jozsef Csicsvari Institute of Science and Technology Austria
Kenneth D. Harris
Kenneth D. Harris University College London
Shigeyoshi Itohara
Shigeyoshi Itohara RIKEN Center for Brain Science
Darrell A. Henze
Darrell A. Henze MSD (United States)
Hirokazu Hirai
Hirokazu Hirai Gunma University
Rafael Yuste
Rafael Yuste Columbia University
Huibert D. Mansvelder
Huibert D. Mansvelder Vrije Universiteit Amsterdam
Christiaan P. J. de Kock
Christiaan P. J. de Kock Vrije Universiteit Amsterdam
Julio C. Martinez-Trujillo
Julio C. Martinez-Trujillo University of Western Ontario

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