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Neuroscience

D-Index
36
Citations
11529
World Ranking
8890
National Ranking
3762

Overview

Darrell A. Henze is affiliated with MSD in the United States and has contributed extensively to research in the fields of biochemistry, genetics, molecular biology, neuroscience, and medicine. Their work spans multiple subfields, including molecular biology, cellular and molecular neuroscience, physiology, pulmonary and respiratory medicine, and social psychology.

The main topics of their research focus on ion channel regulation and function, pain mechanisms and treatments, receptor mechanisms and signaling, neuroscience and neuropharmacology research, nicotinic acetylcholine receptors, neuropeptides and animal physiology, and neuroendocrine regulation and behavior.

Henze has published in a variety of peer-reviewed journals, with recent papers appearing in notable publication venues such as:

  • Journal of Medicinal Chemistry
  • Science Translational Medicine
  • Neuropharmacology
  • Frontiers in Pharmacology
  • Channels

Recent papers authored or co-authored by Henze include:

  • "Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain" (2021, Journal of Medicinal Chemistry)
  • "Na v 1.7 target modulation and efficacy can be measured in nonhuman primate assays" (2021, Science Translational Medicine)
  • "Effects of a novel M4 muscarinic positive allosteric modulator on behavior and cognitive deficits relevant to Alzheimer's disease and schizophrenia in rhesus monkey" (2021, Neuropharmacology)
  • "Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose" (2021, Frontiers in Pharmacology)
  • "Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate" (2020, Pharmaceutical Research)

Collaborations are a significant aspect of Henze's research, with frequent co-authors including:

  • Richard L. Kraus
  • Parul S. Pall
  • Rebecca M. Klein
  • Yuxing Li
  • Christopher S. Burgey

Their research contributions frequently appear in topics related to ion channel physiology and pain treatment mechanisms, reflecting an interdisciplinary approach combining molecular biology, neuroscience, and pharmacology. The emphasis on Nav1.7 inhibitors and allosteric modulators highlights an interest in therapeutic strategies targeting neurological and pain-related disorders.

Best Publications

  • Accuracy of Tetrode Spike Separation as Determined by Simultaneous Intracellular and Extracellular Measurements

    Kenneth D. Harris;Darrell A. Henze;Jozsef Csicsvari;Hajime Hirase

  • Intracellular Features Predicted by Extracellular Recordings in the Hippocampus In Vivo

    Darrell A. Henze;Zsolt Borhegyi;Jozsef Csicsvari;Akira Mamiya

  • Quantitative measures of cluster quality for use in extracellular recordings

    N. Schmitzer-Torbert;J. Jackson;D. Henze;K. Harris

  • On the Origin of the Extracellular Action Potential Waveform: A Modeling Study

    Carl Gold;Darrell A. Henze;Christof Koch;György Buzsáki

  • Integration and Segregation of Activity in Entorhinal-Hippocampal Subregions by Neocortical Slow Oscillations

    Yoshikazu Isomura;Yoshikazu Isomura;Anton Sirota;Simal Özen;Sean Montgomery

  • Interneuron Diversity series: Circuit complexity and axon wiring economy of cortical interneurons

    György Buzsáki;Caroline Geisler;Darrell A. Henze;Xiao Jing Wang

  • Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo.

    Darrell A. Henze;Lucia Wittner;György Buzsáki

  • HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity

    Samer R Eid;Eric D Crown;Eric L Moore;Hongyu A Liang

  • The multifarious hippocampal mossy fiber pathway: a review

    Darrell A. Henze;Nathaniel N. Urban;German Barrionuevo

  • Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells.

    Kenneth D. Harris;Darrell A. Henze;Hajime Hirase;Xavier Leinekugel

  • Massively parallel recording of unit and local field potentials with silicon-based electrodes.

    Jozsef Csicsvari;Darrell A. Henze;Brian Jamieson;Kenneth D. Harris

  • Temporal Interaction between Single Spikes and Complex Spike Bursts in Hippocampal Pyramidal Cells

    Kenneth D Harris;Hajime Hirase;Xavier Leinekugel;Darrell A Henze

  • Neuronal Diversity in GABAergic Long-Range Projections from the Hippocampus

    Shozo Jinno;Thomas Klausberger;Thomas Klausberger;Laszlo F. Marton;Yannis Dalezios;Yannis Dalezios;Yannis Dalezios

  • Action potential threshold of hippocampal pyramidal cells in vivo is increased by recent spiking activity.

    D.A Henze;G Buzsáki

  • Dopamine Increases Excitability of Pyramidal Neurons in Primate Prefrontal Cortex

    Darrell A. Henze;Guillermo R. González-Burgos;Nathaniel N. Urban;David A. Lewis

  • Three-dimensional reconstruction of the axon arbor of a CA3 pyramidal cell recorded and filled in vivo

    Lucia Wittner;Darrell A. Henze;Darrell A. Henze;László Záborszky;György Buzsáki

  • Hippocampal pyramidal cell-interneuron spike transmission is frequency dependent and responsible for place modulation of interneuron discharge.

    Lisa Marshall;Darrell A. Henze;Hajime Hirase;Xavier Leinekugel

  • Using extracellular action potential recordings to constrain compartmental models.

    Carl Gold;Darrell A. Henze;Christof Koch

  • Aspartate and glutamate mediate excitatory synaptic transmission in area CA1 of the hippocampus.

    MW Fleck;DA Henze;G Barrionuevo;AM Palmer

  • The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease.

    Susan M. Catalano;Elizabeth C. Dodson;Darrell A. Henze;Joseph G. Joyce

Frequent Co-Authors

György Buzsáki
György Buzsáki New York University
German Barrionuevo
German Barrionuevo University of Pittsburgh
Kenneth D. Harris
Kenneth D. Harris University College London
Nathaniel N. Urban
Nathaniel N. Urban University of Pittsburgh
Hajime Hirase
Hajime Hirase University of Copenhagen
Jozsef Csicsvari
Jozsef Csicsvari Institute of Science and Technology Austria
David A. Lewis
David A. Lewis University of Pittsburgh
Guillermo Gonzalez-Burgos
Guillermo Gonzalez-Burgos University of Pittsburgh
Christof Koch
Christof Koch Allen Institute for Brain Science
Thomas Klausberger
Thomas Klausberger Medical University of Vienna

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