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Martine Jandrot-Perrus

Martine Jandrot-Perrus

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
9491
World Ranking
13425
National Ranking
508

Overview

Martine Jandrot-Perrus is affiliated with Inserm in France and has a significant body of work in the field of Medicine, focusing especially on Hematology, Cardiology and Cardiovascular Medicine, Epidemiology, Pulmonary and Respiratory Medicine, and Neurology.

Their research primarily addresses topics such as:

  • Platelet Disorders and Treatments
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Acute Ischemic Stroke Management
  • Blood Coagulation and Thrombosis Mechanisms
  • Blood properties and coagulation
  • Cell Adhesion Molecules Research
  • Heparin-Induced Thrombocytopenia and Thrombosis

Several recent papers authored or coauthored by Martine Jandrot-Perrus include:

  • Pharmacological Blockade of Glycoprotein VI Promotes Thrombus Disaggregation in the Absence of Thrombin (2020), published in Arteriosclerosis Thrombosis and Vascular Biology
  • Safety and efficacy of platelet glycoprotein VI inhibition in acute ischaemic stroke (ACTIMIS): a randomised, double-blind, placebo-controlled, phase 1b/2a trial (2024), published in The Lancet Neurology
  • Platelets favor the outgrowth of established metastases (2024), published in Nature Communications
  • Population Pharmacokinetic/Pharmacodynamic Modeling of Glenzocimab (ACT017) a Glycoprotein VI Inhibitor of Collagen-Induced Platelet Aggregation (2020), published in The Journal of Clinical Pharmacology
  • Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition (2022), published in Blood Advances

Frequent coauthors collaborating with Martine Jandrot-Perrus include:

  • Stéphane Loyau
  • Pierre Mangin
  • Mikaël Mazighi
  • Benoît Ho-Tin-Noé
  • Yannick Plétan

Their work has often appeared in these publication venues:

  • Journal of Thrombosis and Haemostasis
  • Research and Practice in Thrombosis and Haemostasis
  • Platelets
  • Arteriosclerosis Thrombosis and Vascular Biology
  • Blood Advances

Best Publications

  • Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily.

    Martine Jandrot-Perrus;Martine Jandrot-Perrus;Martine Jandrot-Perrus;Samantha Busfield;Samantha Busfield;Samantha Busfield;Anne-Helène Lagrue;Anne-Helène Lagrue;Anne-Helène Lagrue;Ximing Xiong;Ximing Xiong;Ximing Xiong

  • Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation.

    Elmina Mammadova-Bach;Véronique Ollivier;Véronique Ollivier;Stéphane Loyau;Stéphane Loyau;Mathieu Schaff

  • Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment.

    Siham Sabri;Adlen Foudi;Siham Boukour;Brigitte Franc

  • Adhesion and Activation of Human Platelets Induced by Convulxin Involve Glycoprotein VI and Integrin α2ॆ1

    Martine Jandrot-Perrus;Anne-Hélène Lagrue;Minoru Okuma;Cassian Bon

  • Bothrojaracin, a new thrombin inhibitor isolated from Bothrops jararaca venom: characterization and mechanism of thrombin inhibition.

    Russolina B. Zingali;Martine Jandrot-Perrus;Marie Claude Guillin;Cassian Bon

  • Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke

    Jean-Philippe Desilles;Stephane Loyau;Varouna Syvannarath;Jaime Gonzalez-Valcarcel

  • Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin

    Catherine Vidal;Blandine Geny;Josiane Melle;Martine Jandrot-Perrus

  • Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice.

    Angèle Gros;Angèle Gros;Varouna Syvannarath;Varouna Syvannarath;Lamia Lamrani;Lamia Lamrani;Véronique Ollivier;Véronique Ollivier

  • Platelet Activation and Aggregation Promote Lung Inflammation and Influenza Virus Pathogenesis

    Vuong Ba Lê;Jochen G. Schneider;Yvonne Boergeling;Fatma Berri

  • Deletion of the p110β isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

    Valérie Martin;Julie Guillermet-Guibert;Gaétan Chicanne;Cendrine Cabou

  • Affinity of low molecular weight fucoidan for P-selectin triggers its binding to activated human platelets.

    Laure Bachelet;Isabelle Bertholon;Damien Lavigne;Roger Vassy

  • Radiolabeled Fucoidan as a P-Selectin Targeting Agent for In Vivo Imaging of Platelet-Rich Thrombus and Endothelial Activation

    François Rouzet;Laure Bachelet-Violette;Jean-Marc Alsac;Michimasa Suzuki

  • Exacerbation of Thromboinflammation by Hyperglycemia Precipitates Cerebral Infarct Growth and Hemorrhagic Transformation.

    Jean-Philippe Desilles;Varouna Syvannarath;Véronique Ollivier;Clément Journé

  • Principal role of glycoprotein VI in alpha2beta1 and alphaIIbbeta3 activation during collagen-induced thrombus formation.

    Christelle Lecut;Anne Schoolmeester;Marijke J.E. Kuijpers;Jos L.V. Broers

  • Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations.

    Bénédicte Dumont;Dominique Lasne;Dominique Lasne;Chantal Rothschild;Maxime Bouabdelli

  • Critical role of neutrophil extracellular traps (NETs) in patients with Behcet's disease.

    Alexandre Le Joncour;Raphael Martos;Stephane Loyau;Nicolas Lelay

  • Differential regulation of actin stress fiber assembly and proplatelet formation by α2β1 integrin and GPVI in human megakaryocytes

    Siham Sabri;Martine Jandrot-Perrus;Jacques Bertoglio;Richard W. Farndale

  • Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology.

    Marie-Christine Bouton;Marie-Christine Bouton;Yacine Boulaftali;Yacine Boulaftali;Benjamin Richard;Benjamin Richard;Véronique Arocas;Véronique Arocas

  • Platelet Glycoprotein VI Dimerization, an Active Process Inducing Receptor Competence, Is an Indicator of Platelet Reactivity

    Stéphane Loyau;Bénédicte Dumont;Véronique Ollivier;Yacine Boulaftali

  • Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

    Ulrike Flierl;Tracy L Nero;Bock Lim;Jane Frances Arthur

Frequent Co-Authors

Jean-Baptiste Michel
Jean-Baptiste Michel University of Lorraine
Jean-Luc Villeval
Jean-Luc Villeval Institut Gustave Roussy
Christian Gachet
Christian Gachet University of Strasbourg
William Vainchenker
William Vainchenker Institut Gustave Roussy
Bernhard Nieswandt
Bernhard Nieswandt University of Würzburg
Steve P. Watson
Steve P. Watson University of Birmingham
Alan T. Nurden
Alan T. Nurden Centre national de la recherche scientifique, CNRS
Johan W. M. Heemskerk
Johan W. M. Heemskerk Maastricht University
François Lanza
François Lanza University of Strasbourg

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