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Biology and Biochemistry

D-Index
82
Citations
28907
World Ranking
3648
National Ranking
270

Overview

Richard W. Farndale is a researcher affiliated with the University of Cambridge in the United Kingdom. Their work primarily spans the field of Medicine, with a focus on several subfields, including Hematology, Biomaterials, Molecular Biology, Immunology and Allergy, and Pulmonary and Respiratory Medicine.

The research contributions of Richard W. Farndale cover diverse topics. Notable areas of study include:

  • Platelet Disorders and Treatments
  • Cell Adhesion Molecules Research
  • Collagen: Extraction and Characterization
  • Blood Properties and Coagulation
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Blood Coagulation and Thrombosis Mechanisms
  • Electrospun Nanofibers in Biomedical Applications

Farndale has contributed to scientific literature published in several journals and venues. Frequent publication targets include:

  • Journal of Thrombosis and Haemostasis
  • Scientific Reports
  • Research and Practice in Thrombosis and Haemostasis
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Apollo (University of Cambridge)

Some of their recent published papers are:

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors (2021), British Journal of Pharmacology
  • The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors (2023), British Journal of Pharmacology
  • Chain alignment of collagen I deciphered using computationally designed heterotrimers (2020), Nature Chemical Biology
  • Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation (2020), Scientific Reports
  • Structural insights into collagen binding by platelet receptor glycoprotein VI (2022), Blood

Collaboration appears to be a significant aspect of their research, with frequent co-authors including:

  • Samir W. Hamaia
  • Arkadiusz Bonna
  • Jean-Daniel Malcor
  • Dominique Bihan
  • Ruth E. Cameron

Best Publications

  • Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue

    Richard W. Farndale;David J. Buttle;Alan J. Barrett

  • Structural Basis of Collagen Recognition by Integrin α2β1

    Jonas Emsley;C.Graham Knight;Richard W. Farndale;Michael J. Barnes

  • Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

    Eric Boilard;Peter A. Nigrovic;Peter A. Nigrovic;Katherine Larabee;Gerald F. M. Watts

  • The Collagen-binding A-domains of Integrins α1β1 and α2β1Recognize the Same Specific Amino Acid Sequence, GFOGER, in Native (Triple-helical) Collagens

    C. Graham Knight;Laurence F. Morton;Anthony R. Peachey;Danny S. Tuckwell

  • Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

    Luc H. Boudreau;Anne Claire Duchez;Nathalie Cloutier;Denis Soulet

  • The role of collagen in thrombosis and hemostasis.

    R. W. Farndale;J. J. Sixma;M. J. Barnes;P. G. De Groot

  • Evaluation of cell binding to collagen and gelatin: a study of the effect of 2D and 3D architecture and surface chemistry.

    Natalia Davidenko;Carlos F. Schuster;Daniel V. Bax;Richard W. Farndale

  • Integrin alpha 2 beta 1-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for alpha 2 beta 1-independent platelet reactivity.

    L F Morton;P G Hargreaves;R W Farndale;R D Young

  • Glycoprotein VI Is a Major Collagen Receptor for Platelet Activation: It Recognizes the Platelet-Activating Quaternary Structure of Collagen, Whereas CD36, Glycoprotein IIb/IIIa, and von Willebrand Factor Do Not

    B Kehrel;S Wierwille;K J Clemetson;O Anders

  • Role for p38 Mitogen-activated Protein Kinase in Platelet Aggregation Caused by Collagen or a Thromboxane Analogue

    Jeremy Saklatvala;Lesley Rawlinson;Richard J. Waller;Simon Sarsfield

  • Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1

    Robert Jan Lebbink;Talitha Eshuis-de Ruiter;Jelle Adelmeijer;Arjan B. Brenkman

  • Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor γ-chain

    Jonathan M Gibbins;Minoru Okuma;Richard Farndale;Michael Barnes

  • Identification in Collagen Type I of an Integrin α2β1-binding Site Containing an Essential GER Sequence

    C. Graham Knight;Laurence F. Morton;David J. Onley;Anthony R. Peachey

  • Release and activation of platelet latent TGF-beta in blood clots during dissolution with plasmin.

    David J. Grainger;Lalage Wakefield;Hugh W. Bethell;Richard W. Farndale

  • Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen.

    C G Knight;L F Morton;D J Onley;A R Peachey

  • Control of crosslinking for tailoring collagen-based scaffolds stability and mechanics

    Natalia Davidenko;CF Schuster;Daniel Bax;N Raynal

  • The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle‐associated immune complexes

    Nathalie Cloutier;Sisareuth Tan;Luc H Boudreau;Catriona Cramb

  • Crosslinking and composition influence the surface properties, mechanical stiffness and cell reactivity of collagen-based films

    Chloe N. Grover;Jessica H. Gwynne;Nicholas Pugh;Samir Hamaia

  • Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated platelets.

    Jonathan Gibbins;Judith Asselin;Richard Farndale;Michael Barnes

  • Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood

    Pia R.-M. Siljander;Imke C. A. Munnix;Peter A. Smethurst;Hans Deckmyn

Frequent Co-Authors

Willem H. Ouwehand
Willem H. Ouwehand University of Cambridge
Ruth E. Cameron
Ruth E. Cameron University of Cambridge
Stewart O. Sage
Stewart O. Sage University of Cambridge
Serena M. Best
Serena M. Best University of Cambridge
Mike Barnes
Mike Barnes University of Manchester
Nicholas A. Watkins
Nicholas A. Watkins NHS Blood and Transplant
Martin Zeitz
Martin Zeitz Charité - University Medicine Berlin
Steve P. Watson
Steve P. Watson University of Birmingham
Johan W. M. Heemskerk
Johan W. M. Heemskerk Maastricht University
Detlef Schuppan
Detlef Schuppan Johannes Gutenberg University of Mainz

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