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Biology and Biochemistry

D-Index
78
Citations
22479
World Ranking
4531
National Ranking
2205

Overview

Gregg B. Fields is affiliated with Florida Atlantic University in the United States. Their research spans multiple disciplines within the sciences, primarily focusing on biochemistry, genetics, molecular biology, and medicine. The work emphasizes key subfields such as molecular biology, cancer research, oncology, genetics, and surgery.

The scientist's main research topics include:

  • Protease and Inhibitor Mechanisms
  • Peptidase Inhibition and Analysis
  • Signaling Pathways in Disease
  • Inflammasome and Immune Disorders
  • Insect Resistance and Genetics
  • Cell Adhesion Molecules Research
  • Computational Drug Discovery Methods

Recent scholarly contributions include the following papers:

  • The Molecular Basis and Clinical Consequences of Chronic Inflammation in Prostatic Diseases: Prostatitis, Benign Prostatic Hyperplasia, and Prostate Cancer, 2023, published in Cancers
  • Discovery and Optimization of Selective Inhibitors of Meprin α (Part I), 2021, published in Pharmaceuticals
  • Discovery and Optimization of Selective Inhibitors of Meprin α (Part II), 2021, published in Pharmaceuticals
  • Skeletal muscle proteome expression differentiates severity of cancer cachexia in mice and identifies loss of fragile X mental retardation syndrome-related protein 1, 2022, published in PROTEOMICS
  • Effects of the Nature of Metal Ion, Protein and Substrate on the Catalytic Center in Matrix Metalloproteinase-1: Insights from Multilevel MD, QM/MM and QM Studies, 2021, published in ChemPhysChem

Their frequent collaborators include Mathangi Ramesh, Michela I. Simone, Joseph Audie, Jürgen Bajorath, and María Laura Bolognesi.

Fields has published extensively in the following venues:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Chemical Biology & Drug Design
  • Pharmaceuticals
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Preprints.org

Best Publications

  • Solid phase peptide synthesis utilizing 9‐fluorenylmethoxycarbonyl amino acids

    Gregg B. Fields;Richard L. Noble

  • Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics

    M. P. Lutolf;J. L. Lauer-Fields;H. G. Schmoekel;H. G. Schmoekel;A. T. Metters

  • A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis.

    David S. King;Cynthia G. Fields;Gregg B. Fields

  • Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis

    Linda Chung;Linda Chung;Deendayal Dinakarpandian;Naoto Yoshida;Janelle L Lauer-Fields;Janelle L Lauer-Fields

  • Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides.

    Hideaki Nagase;Gregg B. Fields

  • Synthetic lipidation of peptides and amino acids: monolayer structure and properties.

    Peter Berndt;Gregg B. Fields;Matthew Tirrell

  • Self-assembling amphiphiles for construction of protein molecular architecture

    Ying-Ching Yu;Peter Berndt;Matthew Tirrell;Gregg B. Fields

  • Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3)

    H Nagase;C G Fields;G B Fields

  • Matrix metalloproteinases and collagen catabolism

    Janelle L. Lauer-Fields;Darius Juska;Gregg B. Fields

  • Regulation of Collagenase Activities of Human Cathepsins by Glycosaminoglycans

    Zhenqiang Li;Yoshiyuki Yasuda;Weijie Li;Matthew Bogyo

  • Proteinlike molecular architecture: Biomaterial applications for inducing cellular receptor binding and signal transduction

    Gregg B. Fields;Janelle L. Lauer;Janelle L. Lauer;Yoav Dori;Pilar Forns;Pilar Forns

  • The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma.

    Gregg B. Fields

  • Interstitial Collagen Catabolism

    Gregg B. Fields

  • Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site

    Moran Grossman;Benjamin Born;Matthias Heyden;Dmitry Tworowski

  • Matrix metalloproteinase collagenolysis in health and disease

    Sabrina Amar;Lyndsay Smith;Gregg B. Fields;Gregg B. Fields

  • Micropatterning gradients and controlling surface densities of photoactivatable biomolecules on self-assembled monolayers of oligo(ethylene glycol) alkanethiolates

    Curtis B. Herbert;Terri L. McLernon;Claire L. Hypolite;Derek N. Adams

  • The history of matrix metalloproteinases: milestones, myths, and misperceptions

    Rugmani Padmanabhan Iyer;Nicolle L. Patterson;Gregg B. Fields;Gregg B. Fields;Merry L. Lindsey

  • MINIMAL LIPIDATION STABILIZES PROTEIN-LIKE MOLECULAR ARCHITECTURE

    Ying-Ching Yu,†,‡;and Matthew Tirrell;Gregg B. Fields

  • A model for interstitial collagen catabolism by mammalian collagenases

    Gregg B. Fields

  • Cellular recognition of synthetic peptide amphiphiles in self-assembled monolayer films.

    Teika Pakalns;Kraig L. Haverstick;Gregg B Fields;James B McCarthy

Frequent Co-Authors

Hideaki Nagase
Hideaki Nagase University of Oxford
Matthew Tirrell
Matthew Tirrell University of Chicago
Merry L. Lindsey
Merry L. Lindsey University of Nebraska Medical Center
Keith Brew
Keith Brew Florida Atlantic University
William R. Roush
William R. Roush Scripps Research Institute
Leo T. Furcht
Leo T. Furcht University of Minnesota
Andrew Miles
Andrew Miles University of Toronto
Richard A. Houghten
Richard A. Houghten Florida International University
James B. McCarthy
James B. McCarthy University of Minnesota
Renato V. Iozzo
Renato V. Iozzo Thomas Jefferson University

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