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Biology and Biochemistry

D-Index
84
Citations
18942
World Ranking
3397
National Ranking
1708

Research.com Recognitions

  • 2000 - Fellow of the American Psychological Association (APA)
  • 1986 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

James B. McCarthy is affiliated with the University of Minnesota in the United States. Their body of research spans biochemistry, genetics, molecular biology, and medicine, with particular emphasis on molecular biology, cell biology, and oncology.

Their recent work includes several published papers focusing on cancer progression, wound repair, and cellular signaling mechanisms. Notable publications include:

  • RHAMM Is a Multifunctional Protein That Regulates Cancer Progression, 2021, International Journal of Molecular Sciences
  • Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer, 2020, Cancers
  • Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression, 2021, Biomolecules
  • Cell-specific expression of the transcriptional regulator RHAMM provides a timing mechanism that controls appropriate wound re-epithelialization, 2020, Journal of Biological Chemistry
  • FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma, 2022, Cell Death and Disease

Their frequent co-authors include:

  • Andrew C. Nelson
  • Eva A. Turley
  • Cornelia Tölg
  • Todd P. Knutson
  • Patrice M. Witschen

James B. McCarthy has published repeatedly in several venues, including:

  • Cancer Research
  • Cancers
  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Molecular Sciences
  • Biomolecules

Their core research fields and subfields encompass:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine
  • Molecular Biology
  • Cell Biology
  • Oncology
  • Clinical Psychology
  • Psychiatry and Mental Health

Main topics of work explored include:

  • Proteoglycans and glycosaminoglycans research
  • Glycosylation and Glycoproteins Research
  • Cancer Cells and Metastasis
  • Fibroblast Growth Factor Research
  • Wound Healing and Treatments
  • Cell Adhesion Molecules Research
  • Suicide and Self-Harm Studies

Throughout their career, James B. McCarthy has been recognized with awards such as the Fellow of the American Association for the Advancement of Science (AAAS) awarded in 1986 and the Fellow of the American Psychological Association (APA) awarded in 2000.

Best Publications

  • Neurite extension by peripheral and central nervous system neurons in response to substratum-bound fibronectin and laminin.

    Sherry L. Rogers;Paul C. Letourneau;Sally L. Palm;James McCarthy

  • Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin.

    Pirkko Huhtala;Martin J. Humphries;James B. McCarthy;Patrice M. Tremble

  • A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion.

    A E Faassen;J A Schrager;D J Klein;T R Oegema

  • Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV.

    Catherine Verfaillie;J B McCarthy;P B McGlave

  • Regulation of Akt/PKB Activation by Tyrosine Phosphorylation

    Riyan Chen;Oekyung Kim;Jiangbo Yang;Kanoka Sato

  • Differential effects of laminin, intact type IV collagen, and specific domains of type IV collagen on endothelial cell adhesion and migration.

    Thomas J. Herbst;James B. McCarthy;Effie C. Tsilibary;Leo T. Furcht

  • The role of cell adhesion proteins--laminin and fibronectin--in the movement of malignant and metastatic cells.

    James B. McCarthy;Michael L. Basara;Sally L. Palm;Daryl F. Sas

  • Differentiation of primitive human multipotent hematopoietic progenitors into single lineage clonogenic progenitors is accompanied by alterations in their interaction with fibronectin.

    Catherine Verfaillie;J B McCarthy;P B McGlave

  • The content and size of hyaluronan in biological fluids and tissues

    Mary K. Cowman;Hong Gee Lee;Kathryn L. Schwertfeger;James B. McCarthy

  • The Hyaluronan Receptors CD44 and Rhamm (CD168) Form Complexes with ERK1,2 That Sustain High Basal Motility in Breast Cancer Cells

    Sara R. Hamilton;Shireen F. Fard;Frouz F. Paiwand;Cornelia Tolg

  • Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation.

    Randolph W. Hurley;James B. McCarthy;Catherine M. Verfaillie

  • Cell-surface and mitotic-spindle RHAMM: moonlighting or dual oncogenic functions?

    Christopher Alan Maxwell;James McCarthy;Eva Turley

  • A synthetic peptide from the COOH-terminal heparin-binding domain of fibronectin promotes focal adhesion formation.

    Anne Woods;James B. McCarthy;Leo T. Furcht;John R. Couchman

  • Human high molecular weight-melanoma-associated antigen (HMW-MAA): a melanoma cell surface chondroitin sulfate proteoglycan (MSCP) with biological and clinical significance.

    Michael R. Campoli;Chien Chung Chang;Toshiro Kageshita;Xinhui Wang

  • Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.

    Kathryn M. Eisenmann;James B. McCarthy;Melanie A. Simpson;Patricia J. Keely

  • Rhamm−/− fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair

    Cornelia Tolg;Sara R. Hamilton;Kerry-Ann Nakrieko;Fatemeh Kooshesh

  • Regulation of human B-cell precursor adhesion to bone marrow stromal cells by cytokines that exert opposing effects on the expression of vascular cell adhesion molecule-1 (VCAM-1)

    Bonnie N. Dittel;James B. McCarthy;Elizabeth A. Wayner;Tucker W. LeBien

  • Adhesion of committed human hematopoietic progenitors to synthetic peptides from the C-terminal heparin-binding domain of fibronectin: cooperation between the integrin alpha 4 beta 1 and the CD44 adhesion receptor

    Catherine Verfaillie;A Benis;J Iida;P B McGlave

  • Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms

    Jianbo Yang;Matthew A. Price;Cheryl L. Neudauer;Christopher Wilson

  • CSPG4, a potential therapeutic target, facilitates malignant progression of melanoma.

    Matthew A. Price;Leah E. Colvin Wanshura;Jianbo Yang;Jennifer Carlson

Frequent Co-Authors

Leo T. Furcht
Leo T. Furcht University of Minnesota
Eva A. Turley
Eva A. Turley University of Western Ontario
Matthew Price
Matthew Price University of Vermont
Amy P.N. Skubitz
Amy P.N. Skubitz University of Minnesota
Guiyuan Li
Guiyuan Li Central South University
Theodore R. Oegema
Theodore R. Oegema Rush University Medical Center
Soldano Ferrone
Soldano Ferrone Harvard University
Xiaoling Li
Xiaoling Li Ministry of Education of the People's Republic of China
Wei Xiong
Wei Xiong University of Pittsburgh
Matthew Tirrell
Matthew Tirrell University of Chicago

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