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Paraskevi Heldin

Paraskevi Heldin

D-Index & Metrics

Biology and Biochemistry

D-Index
46
Citations
7311
World Ranking
18964
National Ranking
300

Overview

Paraskevi Heldin is affiliated with Uppsala University in Sweden and has contributed extensively to the field of biochemistry, genetics, and molecular biology, with a particular focus on cell and molecular biology as well as cancer research. Their work spans several related subfields, including pulmonary and respiratory medicine and periodontics.

The research topics covered by Heldin emphasize areas such as proteoglycans and glycosaminoglycans, glycosylation and glycoproteins, fibroblast growth factors, cancer-related molecular mechanisms, NF-κB signaling pathways, sarcoma diagnosis and treatment, and carbohydrate chemistry and synthesis.

Heldin has authored multiple papers, with recent publications showcasing a range of research interests and findings. Notable recent papers include:

  • A biological guide to glycosaminoglycans: current perspectives and pending questions (2024), FEBS Journal
  • CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence (2022), Cancers
  • Salicylate suppresses the oncogenic hyaluronan network in metastatic breast cancer cells (2020), Matrix Biology Plus
  • The natural antisense transcript HAS2-AS1 regulates breast cancer cells aggressiveness independently from hyaluronan metabolism (2022), Matrix Biology
  • Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells (2022), Cancers

Frequent co-authors collaborating with Heldin include Spyros S. Skandalis, Constantinos Kolliopoulos, Carl-Henrik Heldin, Theodoros Karalis, and Athanasios Chatzopoulos, indicating active partnerships within these research networks.

Heldin's work has been published in a selection of journals, with multiple contributions to Cancers, as well as publications in FEBS Journal, Matrix Biology, Matrix Biology Plus, and Intensive Care Medicine Experimental.

Best Publications

  • Hyaluronan–CD44 interactions as potential targets for cancer therapy

    Suniti Misra;Paraskevi Heldin;Vincent C. Hascall;Nikos K. Karamanos

  • Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts

    P Heldin;T C Laurent;C H Heldin

  • Expression of human hyaluronan synthases in response to external stimuli.

    Annica Jacobson;Jonas Brinck;Michael J. Briskin;Andrew P. Spicer

  • Functional cloning of the cDNA for a human hyaluronan synthase

    Anne M. Shyjan;Paraskevi Heldin;Eugene C. Butcher;Tadashi Yoshino

  • Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells.

    Yuejuan Li;Lingli Li;Tracey Jean Brown;Paraskevi Heldin;Paraskevi Heldin

  • Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB

    Lingli Li;Trias Asteriou;Berit Bernert;Carl-Henrik Heldin

  • Antisense-Mediated Suppression of Hyaluronan Synthase 2 Inhibits the Tumorigenesis and Progression of Breast Cancer

    Lisanthi Udabage;Gary Russell Brownlee;Mark Waltham;Tony Blick

  • Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner.

    Yoshinori Takahashi;Lingli Li;Masaru Kamiryo;Trias Asteriou

  • Synthesis and Assembly of the Hyaluronan-Containing Coats around Normal Human Mesothelial Cells

    Paraskevi Heldin;Håkan Pertoft

  • Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors.

    Annica Jacobson;Mehdi Rahmanian;Kristofer Rubin;Paraskevi Heldin

  • TGFβ and matrix-regulated epithelial to mesenchymal transition

    Aristidis Moustakas;Paraskevi Heldin;Paraskevi Heldin

  • Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-beta 1 involves activation of protein kinase C.

    M Suzuki;T Asplund;H Yamashita;H Yamashita;C H Heldin

  • Efficient TGFβ-induced epithelial–mesenchymal transition depends on hyaluronan synthase HAS2

    Helena Porsch;Berit Bernert;Merima Mehić;A D Theocharis;A D Theocharis

  • Hyaluronan production increases the malignant properties of mesothelioma cells.

    Y Li;Paraskevi Heldin

  • Expression of recombinant hyaluronan synthase (HAS) isoforms in CHO cells reduces cell migration and cell surface CD44.

    Jonas Brinck;Paraskevi Heldin

  • Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1).

    Berit Bernert;Helena Porsch;Paraskevi Heldin

  • Deregulation of hyaluronan synthesis, degradation and binding promotes breast cancer

    Paraskevi Heldin;Kaustuv Basu;Berit Olofsson;Helena Porsch

  • The Activity of Hyaluronan Synthase 2 Is Regulated by Dimerization and Ubiquitination

    Eugenia Karousou;Masaru Kamiryo;Spyros S. Skandalis;Aino Ruusala

  • Irradiation-Induced Expression of Hyaluronan (HA) Synthase 2 and Hyaluronidase 2 Genes in Rat Lung Tissue Accompanies Active Turnover of HA and Induction of Types I and III Collagen Gene Expression

    Yuejuan Li;Mehdi Rahmanian;Charles Widström;Gunter Lepperdinger

  • Human Mesothelioma Cells Produce Factors That Stimulate the Production of Hyaluronan by Mesothelial Cells and Fibroblasts

    Tomas Asplund;Marjan A. Versnel;Torvard C. Laurent;Paraskevi Heldin

Frequent Co-Authors

Carl-Henrik Heldin
Carl-Henrik Heldin Uppsala University
Aristidis Moustakas
Aristidis Moustakas Uppsala University
Torvard C. Laurent
Torvard C. Laurent Uppsala University
Heriberto Rodriguez-Martinez
Heriberto Rodriguez-Martinez Linköping University
Kristofer Rubin
Kristofer Rubin Uppsala University
Nikos K. Karamanos
Nikos K. Karamanos University of Patras
Alberto Passi
Alberto Passi University of Insubria
George N. Tzanakakis
George N. Tzanakakis University of Crete
Terry J. Smith
Terry J. Smith University of Michigan–Ann Arbor
Achilleas D. Theocharis
Achilleas D. Theocharis University of Patras

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