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D-Index & Metrics

Molecular Biology

D-Index
49
Citations
14338
World Ranking
2601
National Ranking
1275

Overview

Coleen T. Murphy is affiliated with Princeton University in the United States. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with extensive work in the subfields of Aging, Molecular Biology, Endocrine and Autonomic Systems, Physiology, and Neurology. The topics addressed in their research cover Genetics, Aging, and Longevity in Model Organisms, Circadian rhythm and melatonin, CRISPR and Genetic Engineering, Mitochondrial Function and Pathology, Gut microbiota and health, Birth, Development, and Health, as well as Physiological and biochemical adaptations.

The scientist has published multiple papers in high-profile journals. Recent significant publications include:

  • "C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance" (2020, Nature)
  • "Metformin rescues Parkinson's disease phenotypes caused by hyperactive mitochondria" (2020, Proceedings of the National Academy of Sciences)
  • "The role of the Cer1 transposon in horizontal transfer of transgenerational memory" (2021, Cell)
  • "Novel elasticity measurements reveal C. elegans cuticle stiffens with age and in a long-lived mutant" (2022, Biophysical Journal)
  • "High-throughput behavioral screen in C. elegans reveals Parkinson's disease drug candidates" (2021, Communications Biology)

Their frequent coauthors include Rachel Kaletsky, Rebecca S. Moore, Salman Sohrabi, Shiyi Zhou, and Titas Sengupta, reflecting ongoing collaborative efforts in their research community.

Publication venues where their work appears most often are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Nature Aging
  • Nature Communications
  • Nature

Their research contributes to understanding the molecular mechanisms underlying aging and longevity, employing the model organism Caenorhabditis elegans for studying genetics and physiological responses. Topics such as transgenerational memory, mitochondrial function in neurodegenerative diseases like Parkinson's, and the role of microbiota interaction feature prominently in their work.

Best Publications

  • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

    Coleen T. Murphy;Steven A. McCarroll;Cornelia I. Bargmann;Andrew Fraser

  • Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

    Ao Lin Hsu;Coleen T. Murphy;Cynthia Kenyon

  • Insulin/insulin-like growth factor signaling in C. elegans.

    Coleen T. Murphy;Patrick J. Hu

  • Comparing genomic expression patterns across species identifies shared transcriptional profile in aging.

    Steven A. McCarroll;Coleen T. Murphy;Sige Zou;Scott D. Pletcher;Scott D. Pletcher

  • Condition‐adapted stress and longevity gene regulation by Caenorhabditis elegans SKN‐1/Nrf

    Riva de Paula Oliveira;Jess Porter Abate;Kieran Dilks;Jessica Landis

  • Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.

    Seung-Jae Lee;Coleen T. Murphy;Cynthia Kenyon

  • PQM-1 Complements DAF-16 as a Key Transcriptional Regulator of DAF-2-Mediated Development and Longevity

    Ronald G. Tepper;Jasmine Ashraf;Rachel Kaletsky;Gunnar Kleemann

  • Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity

    Collin Y. Ewald;Collin Y. Ewald;Jess N. Landis;Jess Porter Abate;Jess Porter Abate;Coleen T. Murphy

  • Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.

    Amanda L. Kauffman;Jasmine M. Ashraf;M. Ryan Corces-Zimmerman;Jessica N. Landis

  • TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance

    Shijing Luo;Gunnar A. Kleemann;Jasmine M. Ashraf;Wendy M. Shaw

  • The C. elegans TGF-β Dauer Pathway Regulates Longevity via Insulin Signaling

    Wendy M. Shaw;Shijing Luo;Jessica Landis;Jasmine Ashraf

  • Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance.

    Rebecca S. Moore;Rachel Kaletsky;Coleen T. Murphy

  • The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators

    Rachel Kaletsky;Vanisha Lakhina;Rachel Arey;April Williams

  • The search for DAF-16/FOXO transcriptional targets: Approaches and discoveries

    Coleen T. Murphy

  • C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation

    Jeong-Hoon Hahm;Sunhee Kim;Race DiLoreto;Cheng Shi

  • Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans

    Coleen T. Murphy;Seung-Jae Lee;Cynthia Kenyon

  • The cell biology of aging

    Race DiLoreto;Coleen T. Murphy

  • Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression.

    Rachel Kaletsky;Victoria Yao;April Williams;Alexi M. Runnels

  • C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance

    Rachel Kaletsky;Rebecca S. Moore;Geoffrey D. Vrla;Lance R. Parsons

  • TGF-ß Sma/Mab Signaling Mutations Uncouple Reproductive Aging from Somatic Aging

    Shijing Luo;Wendy M. Shaw;Jasmine Ashraf;Coleen T. Murphy

Frequent Co-Authors

Cynthia Kenyon
Cynthia Kenyon University of California, San Francisco
Olga G. Troyanskaya
Olga G. Troyanskaya Princeton University
James A. Spudich
James A. Spudich Stanford University
Zemer Gitai
Zemer Gitai Princeton University
Harmen J. Bussemaker
Harmen J. Bussemaker Columbia University
T. Keith Blackwell
T. Keith Blackwell Harvard University
Hong Gil Nam
Hong Gil Nam Daegu Gyeongbuk Institute of Science and Technology
Gary W. Miller
Gary W. Miller Columbia University
Cornelia I. Bargmann
Cornelia I. Bargmann Rockefeller University
Steven A. McCarroll
Steven A. McCarroll Harvard University

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