Gordon J. Lithgow mostly deals with Caenorhabditis elegans, Longevity, Genetics, Transcription factor and Cell biology. The Caenorhabditis elegans study which covers Wild type that intersects with Heat shock protein, Regulation of gene expression and Hedgehog signaling pathway. His studies in Longevity integrate themes in fields like Phenotype, Daf-16 and Normal aging.
The Gene, Kinase and Scaffold protein research he does as part of his general Genetics study is frequently linked to other disciplines of science, such as EIF4G and Translation initiation complex, therefore creating a link between diverse domains of science. His Transcription factor research includes elements of Ageing, Sequence analysis, Protein aggregation and Caenorhabditis briggsae. His Protein folding study, which is part of a larger body of work in Cell biology, is frequently linked to HSF1, bridging the gap between disciplines.
His primary areas of study are Caenorhabditis elegans, Longevity, Genetics, Cell biology and Gene. His Caenorhabditis elegans research incorporates elements of Phenotype, Signal transduction, Mutant and Mutation. His Longevity research incorporates themes from Natural selection, Disease, Neuroscience and Ageing.
In the subject of general Genetics, his work in Transcription factor, Daf-16 and Wild type is often linked to RNA interference and Daf-2, thereby combining diverse domains of study. His research investigates the link between Cell biology and topics such as Regulation of gene expression that cross with problems in Hedgehog signaling pathway. While the research belongs to areas of Gene, Gordon J. Lithgow spends his time largely on the problem of Molecular biology, intersecting his research to questions surrounding Gene knockdown.
Gordon J. Lithgow mainly investigates Caenorhabditis, Pharmacology, Computational biology, Cell biology and Caenorhabditis elegans. His work carried out in the field of Pharmacology brings together such families of science as Agonist, Obeticholic acid and Farnesoid X receptor. The Cell biology study combines topics in areas such as Mutant, Gene and Neurodegeneration.
His Mutant research focuses on Ubiquitin and how it relates to Protein aggregation. His Caenorhabditis elegans study integrates concerns from other disciplines, such as Lysis and Data-independent acquisition. Gordon J. Lithgow combines Scope and Longevity in his studies.
Gordon J. Lithgow focuses on Caenorhabditis, Computational biology, Caenorhabditis elegans, Identification and Multicellular organism. His Caenorhabditis research is multidisciplinary, incorporating elements of Pharmacology and Tyrosine-kinase inhibitor. His work on Geriatrics gerontology expands to the thematically related Computational biology.
His study in Caenorhabditis elegans is interdisciplinary in nature, drawing from both Neurodegeneration, TFEB, Mutant, Cell biology and Mitophagy. His Identification research is multidisciplinary, relying on both Healthy ageing and Ageing.
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Extension of life-span with superoxide dismutase/catalase mimetics
Simon Melov;Joanne Ravenscroft;Sarwatt Malik;Matt S. Gill.
Geroscience: Linking Aging to Chronic Disease
Brian K. Kennedy;Shelley L. Berger;Anne Brunet;Judith Campisi;Judith Campisi.
Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.
Gordon J. Lithgow;Tiffany M. White;Simon Melov;Thomas E. Johnson.
Proceedings of the National Academy of Sciences of the United States of America (1995)
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans.
Kally Z. Pan;Julia E. Palter;Aric N. Rogers;Anders Olsen.
Aging Cell (2007)
MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8.
Dipa Bhaumik;Gary K. Scott;Shiruyeh Schokrpur;Christopher K. Patil.
Aging (Albany NY) (2009)
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
Rute Martins;Gordon J. Lithgow;Wolfgang Link.
Aging Cell (2016)
Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
Silvestre Alavez;Maithili C. Vantipalli;David J. S. Zucker;David J. S. Zucker;Ida M. Klang;Ida M. Klang.
Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin‐like signals
Glenda A. Walker;Gordon J. Lithgow;Gordon J. Lithgow.
Aging Cell (2003)
Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans
Dalia Barsyte;David A. Lovejoy;Gordon J. Lithgow.
The FASEB Journal (2001)
Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods.
Debraj GuhaThakurta;Lisanne Palomar;Gary D. Stormo;Pat Tedesco.
Genome Research (2002)
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