World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
18493
World Ranking
12301
National Ranking
5263

Overview

Pankaj Kapahi is affiliated with the Buck Institute for Research on Aging in the United States. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine, with a focus on several subfields including physiology, aging, molecular biology, clinical biochemistry, and endocrine and autonomic systems.

The scientist's work covers a range of topics, with significant emphasis on:

  • Genetics, aging, and longevity in model organisms
  • Advanced glycation end products research
  • Circadian rhythm and melatonin
  • Diet and metabolism studies
  • Telomeres, telomerase, and senescence
  • Dietary effects on health
  • Adipose tissue and metabolism

They have contributed to multiple recent papers including:

  • Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics (2020), published in Journal of Proteome Research
  • NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health (2022), published in Nature Aging
  • Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila (2020), published in PLoS Genetics
  • Advanced glycation end products (AGEs) and its receptor, RAGE, modulate age-dependent COVID-19 morbidity and mortality. A review and hypothesis (2021), published in International Immunopharmacology
  • GWAS for Lifespan and Decline in Climbing Ability in Flies upon Dietary Restriction Reveal decima as a Mediator of Insulin-like Peptide Production (2020), published in Current Biology

Pankaj Kapahi has published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Innovation in Aging, eLife, and Nature Communications. Their contributions reflect a broad engagement with both preprint and peer-reviewed platforms.

Frequent collaborators include Kenneth A. Wilson, Sudipta Bar, Birgit Schilling, Parminder Singh, and Jennifer Beck, with collaboration counts ranging from 12 to 17 shared publications.

Best Publications

  • Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase

    Antonio Rossi;Pankaj Kapahi;Gioacchino Natoli;Takayuki Takahashi

  • Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway

    Pankaj Kapahi;Brian M Zid;Tony Harper;Daniel Koslover

  • From discoveries in ageing research to therapeutics for healthy ageing

    Judith Campisi;Pankaj Kapahi;Gordon J. Lithgow;Simon Melov

  • MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

    Remi Martin Laberge;Yu Sun;Arturo V. Orjalo;Christopher K. Patil

  • With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging.

    Pankaj Kapahi;Di Chen;Aric N. Rogers;Subhash D. Katewa

  • 4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

    Brian M. Zid;Aric N. Rogers;Subhash D. Katewa;Misha A. Vargas

  • Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans.

    Kally Z. Pan;Julia E. Palter;Aric N. Rogers;Anders Olsen

  • Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics

    Kendra J. Adams;Brian Pratt;Neelanjan Bose;Laura G. Dubois

  • The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality.

    Jyotiska Chaudhuri;Yasmin Bains;Sanjib Guha;Arnold Kahn

  • Cellular senescence: a link between cancer and age-related degenerative disease?

    Judith Campisi;Julie K. Andersen;Pankaj Kapahi;Simon Melov

  • Inhibition of NF-κB Activation by Arsenite through Reaction with a Critical Cysteine in the Activation Loop of IκB Kinase

    Pankaj Kapahi;Takayuki Takahashi;Gioacchino Natoli;Stephen R. Adams

  • Positive correlation between mammalian life span and cellular resistance to stress

    Pankaj Kapahi;Michael E Boulton;Thomas B.L Kirkwood

  • Allocrine modulation of feeding behavior by the Sex Peptide of Drosophila.

    Gil B. Carvalho;Pankaj Kapahi;David J. Anderson;Seymour Benzer

  • Dietary restriction and lifespan: Lessons from invertebrate models.

    Pankaj Kapahi;Matt Kaeberlein;Malene Hansen

  • Late-life rapamycin treatment reverses age-related heart dysfunction

    James M. Flynn;Monique N. O'Leary;Christopher A. Zambataro;Emmeline C. Academia

  • HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans.

    Di Chen;Emma Lynn Thomas;Pankaj Kapahi

  • SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

    Jiyung Shin;Ming He;Ming He;Yufei Liu;Silvana Paredes;Silvana Paredes

  • A Role for S6 Kinase and Serotonin in Postmating Dietary Switch and Balance of Nutrients in D. melanogaster

    Misha A. Vargas;Ningguang Luo;Atsushi Yamaguchi;Pankaj Kapahi

  • Glucocorticoids Suppress Selected Components of the Senescence-Associated Secretory Phenotype

    Remi-Martin Laberge;Lili Zhou;Lili Zhou;Melissa R Sarantos;Francis Rodier

  • Intramyocellular Fatty-Acid Metabolism Plays a Critical Role in Mediating Responses to Dietary Restriction in Drosophila melanogaster

    Subhash D. Katewa;Fabio Demontis;Marysia Kolipinski;Allan Hubbard

Frequent Co-Authors

Judith Campisi
Judith Campisi Buck Institute for Research on Aging
Simon Melov
Simon Melov Buck Institute for Research on Aging
Gordon J. Lithgow
Gordon J. Lithgow Buck Institute for Research on Aging
Amit Sharma
Amit Sharma Microsoft (United States)
Seymour Benzer
Seymour Benzer California Institute of Technology
Marco Demaria
Marco Demaria University Medical Center Groningen
Birgit Schilling
Birgit Schilling Buck Institute for Research on Aging
Julie K. Andersen
Julie K. Andersen Buck Institute for Research on Aging
Bradford W. Gibson
Bradford W. Gibson Buck Institute for Research on Aging
Sean D. Mooney
Sean D. Mooney University of Washington

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